Generalized bullous fixed drug eruption imitating toxic epidermal necrolysis: a case report and literature review

• Published in: Dermatology online journal Vol. 23; no. 7
• Main Authors: Mitre, Victoria, Applebaum, Danielle S, Albahrani, Yasser, Hsu, Sylvia
• Format: Journal Article
• Language: English
• Published: United States 15.07.2017
• Subjects: Antigens, Differentiation, T-Lymphocyte - blood; Ceftriaxone - adverse effects; Diagnosis, Differential; Drug Eruptions - diagnosis; Drug Eruptions - etiology; Drug Eruptions - pathology; Female; Humans; Immunohistochemistry; Middle Aged; Skin - pathology; Skin Diseases, Vesiculobullous - chemically induced; Skin Diseases, Vesiculobullous - diagnosis; Skin Diseases, Vesiculobullous - pathology; Stevens-Johnson Syndrome - diagnosis

Fixed drug eruption (FDE) is defined as sharply demarcated erythematous patches or plaques that occur secondary to systemic exposure to a causative medication. Eruptions are deemed "fixed" because upon repeated exposure they recur at previously affected sites. Generalized bullous fixed dru...