5-Hydroxytryptamine 4(a) Receptor Is Coupled to the Gα Subunit of Heterotrimeric G13 Protein

• Published in: The Journal of biological chemistry Vol. 277; no. 23; pp. 20812 - 20819
• Main Authors: Ponimaskin, Evgeni G., Profirovic, Jasmina, Vaiskunaite, Rita, Richter, Diethelm W., Voyno-Yasenetskaya, Tatyana A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 07.06.2002

Serotonin (5-hydroxytryptamine (5-HT)) is an important neurotransmitter that regulates multiple events in the central nervous system. Many of the 5-HT functions are mediated via G protein-coupled receptors that are coupled to multiple heterotrimeric G proteins, including Gs, Gi, and Gq subfamilies (...