Salts of rucaparib with dicarboxylic acids: synthesis, crystal structures and solubility

• Published in: CrystEngComm Vol. 24; no. 44; pp. 7813 - 782
• Main Authors: Wu, Chao, Gao, Lu, Xiong, Jing, Dai, Xia-Lin, Gao, Wei, Lu, Tong-Bu, Chen, Jia-Mei
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 14.11.2022
• Subjects: Bioavailability; Cancer; Crystal structure; Dicarboxylic acids; Fumaric acid; Hygroscopicity; Infrared analysis; Ribose; Solubility

Rucaparib (RUC) is a potent poly (ADP-ribose) polymerase inhibitor for the treatment of advanced ovarian cancer and recurrent epithelial ovarian cancer. It is marketed in the form of its camsylate salt with a solubility of 1.4 nmol L −1 and absolute oral bioavailability of 36-37%. To expand the soli...