Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae

Pleurocorols A (1) and B (2) with unprecedented carbon skeletons were isolated from the fruiting bodies of Pleurotus cornucopiae. The structures of compounds 1 and 2 were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)abeo-ergostane and 5(6 → 7), 11(9 → 7)diabeo-ergosta...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 7; no. 15; pp. 2022 - 2028
Main Authors Kikuchi, Takashi, Mori, Maki, Yasuko In, Zhang, Jie, Yamada, Takeshi, Hirano, Tomoya
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 01.01.2020
Subjects
Crystallography
Cytotoxicity
Fruit bodies
Nitric oxide
Organic chemistry
Pleurotus cornucopiae
Steroid hormones
Steroids
Tumor cell lines
X-ray crystallography
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Summary:Pleurocorols A (1) and B (2) with unprecedented carbon skeletons were isolated from the fruiting bodies of Pleurotus cornucopiae. The structures of compounds 1 and 2 were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)abeo-ergostane and 5(6 → 7), 11(9 → 7)diabeo-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.
ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo00605j