Percentage arterial enhancement: An objective index for accurate identification of parathyroid adenoma/hyperplasia in primary hyperparathyroidism
Summary Background Radiation exposure to neck by four‐dimensional computerized tomography (4DCT) is relatively high and limits its use as a first‐line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim...
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Published in | Clinical endocrinology (Oxford) Vol. 87; no. 6; pp. 791 - 798 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.12.2017
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Subjects | |
Online Access | Get full text |
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Abstract | Summary
Background
Radiation exposure to neck by four‐dimensional computerized tomography (4DCT) is relatively high and limits its use as a first‐line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery‐naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes.
Materials and method
Retrospective study of 49 PHPT patients {(44 single‐gland diseases (SGD) and five multiple‐gland disease (MGD)} who underwent 4DCT (unenhanced, early arterial, early venous and delayed venous phase) pre‐operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as “(HU in a specific enhanced phase‐HU in unenhanced phase)/HU in unenhanced phase” ×100.
Results
Inter‐rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD, sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD, 4DCT showed 50% sensitivity and 100% PPV. Percentage arterial enhancement showed highest area under curve (AUC=0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut‐off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions.
Conclusions
We propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia. |
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AbstractList | Summary
Background
Radiation exposure to neck by four‐dimensional computerized tomography (4DCT) is relatively high and limits its use as a first‐line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery‐naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes.
Materials and method
Retrospective study of 49 PHPT patients {(44 single‐gland diseases (SGD) and five multiple‐gland disease (MGD)} who underwent 4DCT (unenhanced, early arterial, early venous and delayed venous phase) pre‐operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as “(HU in a specific enhanced phase‐HU in unenhanced phase)/HU in unenhanced phase” ×100.
Results
Inter‐rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD, sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD, 4DCT showed 50% sensitivity and 100% PPV. Percentage arterial enhancement showed highest area under curve (AUC=0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut‐off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions.
Conclusions
We propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia. BACKGROUNDRadiation exposure to neck by four-dimensional computerized tomography (4DCT) is relatively high and limits its use as a first-line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery-naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes.MATERIALS AND METHODRetrospective study of 49 PHPT patients {(44 single-gland diseases (SGD) and five multiple-gland disease (MGD)} who underwent 4DCT (unenhanced, early arterial, early venous and delayed venous phase) pre-operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as "(HU in a specific enhanced phase-HU in unenhanced phase)/HU in unenhanced phase" ×100.RESULTSInter-rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD, sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD, 4DCT showed 50% sensitivity and 100% PPV. Percentage arterial enhancement showed highest area under curve (AUC=0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut-off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions.CONCLUSIONSWe propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia. Radiation exposure to neck by four-dimensional computerized tomography (4DCT) is relatively high and limits its use as a first-line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery-naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes. Retrospective study of 49 PHPT patients {(44 single-gland diseases (SGD) and five multiple-gland disease (MGD)} who underwent 4DCT (unenhanced, early arterial, early venous and delayed venous phase) pre-operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as "(HU in a specific enhanced phase-HU in unenhanced phase)/HU in unenhanced phase" ×100. Inter-rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD, sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD, 4DCT showed 50% sensitivity and 100% PPV. Percentage arterial enhancement showed highest area under curve (AUC=0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut-off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions. We propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia. Summary Background Radiation exposure to neck by four‐dimensional computerized tomography (4 DCT ) is relatively high and limits its use as a first‐line investigation in evaluation of primary hyperparathyroidism ( PHPT ). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4 DCT in cohort of surgery‐naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes. Materials and method Retrospective study of 49 PHPT patients {(44 single‐gland diseases ( SGD ) and five multiple‐gland disease ( MGD )} who underwent 4 DCT (unenhanced, early arterial, early venous and delayed venous phase) pre‐operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as “( HU in a specific enhanced phase‐ HU in unenhanced phase)/ HU in unenhanced phase” ×100. Results Inter‐rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD , sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD , 4 DCT showed 50% sensitivity and 100% PPV . Percentage arterial enhancement showed highest area under curve ( AUC =0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut‐off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions. Conclusions We propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia. |
Author | Sonawane, Sushil Dalvi, Abhay Lila, Anurag R. Shah, Nalini S. Garle, Mahadev N. Goroshi, Shetteppa Bandgar, Tushar R. Goroshi, Manjunath Hira, Priya Sathe, Pragati Jadhav, Swati S. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28656592$$D View this record in MEDLINE/PubMed |
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Keywords | arterial enhancement four-dimensional computed tomography dual-phase CT percentage arterial enhancement primary hyperparathyroidism |
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Radiation exposure to neck by four‐dimensional computerized tomography (4DCT) is relatively high and limits its use as a first‐line... Radiation exposure to neck by four-dimensional computerized tomography (4DCT) is relatively high and limits its use as a first-line investigation in evaluation... Summary Background Radiation exposure to neck by four‐dimensional computerized tomography (4 DCT ) is relatively high and limits its use as a first‐line... BACKGROUNDRadiation exposure to neck by four-dimensional computerized tomography (4DCT) is relatively high and limits its use as a first-line investigation in... |
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SubjectTerms | Adenoma - diagnostic imaging Adenoma - pathology Adolescent Adult Aged arterial enhancement dual‐phase CT Female Four-Dimensional Computed Tomography Humans Hyperparathyroidism, Primary - diagnostic imaging Hyperparathyroidism, Primary - pathology Middle Aged Parathyroid Neoplasms - diagnostic imaging Parathyroid Neoplasms - pathology percentage arterial enhancement primary hyperparathyroidism Retrospective Studies Young Adult |
Title | Percentage arterial enhancement: An objective index for accurate identification of parathyroid adenoma/hyperplasia in primary hyperparathyroidism |
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