Current understanding of genomic stability maintenancein pluripotent stem cells

• Published in: Acta biochimica et biophysica Sinica Vol. 54; no. 6; pp. 858 - 863
• Main Author: Zheng, Ping
• Format: Journal Article
• Language: English
• Published: China China Science Publishing & Media Ltd 25.05.2022
• Subjects: Cell Differentiation - genetics; DNA damage response; Genomic Instability; genomic stability; Humans; pluripotent stem cell; Pluripotent Stem Cells - metabolism; Regenerative Medicine; DNA damage response; genomic stability; pluripotent stem cell

Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs c...