Current understanding of genomic stability maintenancein pluripotent stem cells

Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs c...

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Published inActa biochimica et biophysica Sinica Vol. 54; no. 6; pp. 858 - 863
Main Author Zheng, Ping
Format Journal Article
LanguageEnglish
Published China China Science Publishing & Media Ltd 25.05.2022
Subjects
Cell Differentiation - genetics
DNA damage response
Genomic Instability
genomic stability
Humans
pluripotent stem cell
Pluripotent Stem Cells - metabolism
Regenerative Medicine
DNA damage response
genomic stability
pluripotent stem cell
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Abstract Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs can cause developmental failure or abnormalities. Understanding how PSCs maintain genome stability is of critical importance. Due to their fundamental role in organism development, PSCs must maintain superior stable genome than differentiated cells. However, the underlying mechanisms are far from clear. Very limited studies suggest that PSCs utilize specific strategies and regulators to robustly improve genome stability. In this review, we summarize the current understandings of the unique properties of genome stability maintenance in PSCs.
AbstractList Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs can cause developmental failure or abnormalities. Understanding how PSCs maintain genome stability is of critical importance. Due to their fundamental role in organism development, PSCs must maintain superior stable genome than differentiated cells. However, the underlying mechanisms are far from clear. Very limited studies suggest that PSCs utilize specific strategies and regulators to robustly improve genome stability. In this review, we summarize the current understandings of the unique properties of genome stability maintenance in PSCs.
Author Zheng, Ping
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Keywords DNA damage response
genomic stability
pluripotent stem cell
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Snippet Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative...
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SubjectTerms Cell Differentiation - genetics
DNA damage response
Genomic Instability
genomic stability
Humans
pluripotent stem cell
Pluripotent Stem Cells - metabolism
Regenerative Medicine
Title Current understanding of genomic stability maintenancein pluripotent stem cells
URI https://www.ncbi.nlm.nih.gov/pubmed/35713312
https://search.proquest.com/docview/2678423310
https://doaj.org/article/4e3cda305fd24018bbf7b99eea0aed88
Volume 54
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