Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

• Published in: Science immunology Vol. 9; no. 99; p. eadp0344
• Main Authors: Appios, Anna, Davies, James, Sirvent, Sofia, Henderson, Stephen, Trzebanski, Sébastien, Schroth, Johannes, Law, Morven L, Carvalho, Inês Boal, Pinto, Marlene Magalhaes, Carvalho, Cyril, Kan, Howard Yuan-Hao, Lovlekar, Shreya, Major, Christina, Vallejo, Andres, Hall, Nigel J, Ardern-Jones, Michael, Liu, Zhaoyuan, Ginhoux, Florent, Henson, Sian M, Gentek, Rebecca, Emmerson, Elaine, Jung, Steffen, Polak, Marta E, Bennett, Clare L
• Format: Journal Article
• Language: English
• Published: United States 06.09.2024
• Subjects: Animals; Cell Differentiation - immunology; Female; Humans; Langerhans Cells - cytology; Langerhans Cells - immunology; Mice; Mice, Inbred C57BL; Monocytes - cytology; Monocytes - immunology; Skin - cytology; Skin - immunology

Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived, tissue-resident macrophages in skin innervation and repair and as migrating professional antigen-presenting cells, a function classically assigned to dendritic cells (DCs). Here, we demonstrate that both intrin...