ZBTB7A promotes migration, invasion and metastasis of human breast cancer cells through NF-κB-induced epithelial–mesenchymal transition in vitro and in vivo

• Published in: Journal of biochemistry (Tokyo) Vol. 166; no. 6; pp. 485 - 493
• Main Authors: Mao, Anyun, Chen, Maojian, Qin, Qinghong, Liang, Zhijie, Jiang, Wei, Yang, Weiping, Wei, Changyuan
• Format: Journal Article
• Language: English
• Published: England 01.12.2019
• Subjects: Animals; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Movement; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epithelial-Mesenchymal Transition; Female; Humans; Mammary Neoplasms, Experimental - metabolism; Mammary Neoplasms, Experimental - pathology; Mice; Mice, Nude; NF-kappa B - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor Cells, Cultured; NF-κB; breast cancer; EMT; ZBTB7A

It has been generally confirmed that zinc finger and BTB domain containing 7A (ZBTB7A) plays an important role in the occurrence and progression of malignant tumours, but the promotion or inhibition effect is related to tumour type. The mechanism between ZBTB7A and breast cancer is not well understo...