Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif
A series of macrocyclic α-keto amides containing the D-Phe-Pro-Arg (fPR) motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. Structure-function studies, relating ring size and modifications at the P3 and P1' positions to enzyme inhibition, are des...
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Published in | Bioorganic & medicinal chemistry letters Vol. 6; no. 24; pp. 2947 - 2952 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
17.12.1996
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Abstract | A series of macrocyclic α-keto amides containing the D-Phe-Pro-Arg (fPR) motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. Structure-function studies, relating ring size and modifications at the P3 and P1' positions to enzyme inhibition, are described. An X-ray crystallo-graphic study was performed on a ternary complex formed from
3i, thrombin, and hirugen.
A series of macrocyclic thrombin inhibitors (
3 and
4) containing the D-Phe-Pro-Arg motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. An X-ray crystallographic study was performed on a complex formed from
3i (R(CH
2)
2Ph; m = 7; XO; ZCH
2), thrombin, and hirugen. |
---|---|
AbstractList | A series of macrocyclic α-keto amides containing the D-Phe-Pro-Arg (fPR) motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. Structure-function studies, relating ring size and modifications at the P3 and P1' positions to enzyme inhibition, are described. An X-ray crystallo-graphic study was performed on a ternary complex formed from
3i, thrombin, and hirugen.
A series of macrocyclic thrombin inhibitors (
3 and
4) containing the D-Phe-Pro-Arg motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. An X-ray crystallographic study was performed on a complex formed from
3i (R(CH
2)
2Ph; m = 7; XO; ZCH
2), thrombin, and hirugen. |
Author | Maryanoff, Bruce E. Greco, Michael N. Kauffman, Jack A. Lewis, Joan M. Andrade-Gordon, Patricia Tulinsky, Alexander Powell, Eugene T. Hecker, Leonard R. Ganesh, Venkatapathy |
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Cites_doi | 10.1021/bi00107a001 10.1002/pro.5560050504 10.1021/jm00055a002 10.1002/j.1460-2075.1989.tb08511.x 10.1016/S0065-7743(08)60921-5 10.1016/S0021-9258(18)42599-9 10.1016/0968-0896(95)00104-O 10.1002/pro.5560010402 10.1016/0022-2836(91)80074-5 10.1016/0968-0896(95)00098-2 |
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References | Martin, Robertson, Turk, Huber, Bode, Edwards (BIB8) 1992; 267 (BIB11) 1995; 3 BIB17 Bode, Mayr, Baumann, Huber, Stone, Hofsteenge (BIB10) 1989; 8 (BIB1) 1992 Shuman, Rothenberge, Campbell, Smith, Gifford-Moore, Gesellchen (BIB18) 1993; 36 Das, Kimball (BIB4) 1995; 3 Kimball (BIB6) 1995; 1 Jackson, Crowe, Frank, Wilson, Coffman, Utterback, Jakubowski, Smith (BIB16) 1992; 261 Skrzypczak-Jankun, Carperos, Ravichandran, Tulinsky, Westbrook, Maraganore (BIB20) 1991; 221 Maryanoff, Zhang, Greco, Glover, Kauffman, Andrade-Gordon (BIB13) 1995; 3 Maryanoff, Qiu, Padmanabhan, Tulinsky, Almond, Andrade-Gordon, Greco, Kauffman, Nicolaou, Liu, Brungs, Fusetani (BIB12) 1993; 90 Maryanoff, Greco, Zhang, Andrade-Gordon, Kauffman, Nicolaou, Liu, Brungs (BIB14) 1995; 117 Davie, Fugikawa, Kisiel (BIB2) 1991; 30 BIB15 Talbot, Butler (BIB3) 1990; 3 Scarborough (BIB5) 1995; 30 Bode, Turk, Karshikov (BIB9) 1992; 1 Ganesh, Lee, Clardy, Tulinsky (BIB19) 1996; 5 BIB21 (BIB7) 1992 BIB22 Bode (10.1016/S0960-894X(96)00554-9_BIB9) 1992; 1 Skrzypczak-Jankun (10.1016/S0960-894X(96)00554-9_BIB20) 1991; 221 Davie (10.1016/S0960-894X(96)00554-9_BIB2) 1991; 30 Martin (10.1016/S0960-894X(96)00554-9_BIB8) 1992; 267 (10.1016/S0960-894X(96)00554-9_BIB11) 1995; 3 Maryanoff (10.1016/S0960-894X(96)00554-9_BIB14) 1995; 117 (10.1016/S0960-894X(96)00554-9_BIB1) 1992 (10.1016/S0960-894X(96)00554-9_BIB7) 1992 Das (10.1016/S0960-894X(96)00554-9_BIB4) 1995; 3 Ganesh (10.1016/S0960-894X(96)00554-9_BIB19) 1996; 5 Maryanoff (10.1016/S0960-894X(96)00554-9_BIB12) 1993; 90 Jackson (10.1016/S0960-894X(96)00554-9_BIB16) 1992; 261 Talbot (10.1016/S0960-894X(96)00554-9_BIB3) 1990; 3 Maryanoff (10.1016/S0960-894X(96)00554-9_BIB13) 1995; 3 Shuman (10.1016/S0960-894X(96)00554-9_BIB18) 1993; 36 Scarborough (10.1016/S0960-894X(96)00554-9_BIB5) 1995; 30 Bode (10.1016/S0960-894X(96)00554-9_BIB10) 1989; 8 Kimball (10.1016/S0960-894X(96)00554-9_BIB6) 1995; 1 |
References_xml | – volume: 261 start-page: 546 year: 1992 ident: BIB16 publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Smith – ident: BIB22 – volume: 30 start-page: 71 year: 1995 ident: BIB5 publication-title: Annu. Rep. Med. Chem. contributor: fullname: Scarborough – volume: 1 start-page: 441 year: 1995 ident: BIB6 publication-title: Curr. Pharm. Design contributor: fullname: Kimball – volume: 3 year: 1995 ident: BIB11 publication-title: Bioorg. Med. Chem. – start-page: 63 year: 1992 end-page: 85 ident: BIB7 article-title: Thrombin: Structure and Function – volume: 8 start-page: 3467 year: 1989 ident: BIB10 publication-title: EMBO J. contributor: fullname: Hofsteenge – ident: BIB21 – year: 1992 ident: BIB1 article-title: Thrombin: Structure and Function – volume: 90 start-page: 8048 year: 1993 ident: BIB12 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Fusetani – volume: 117 start-page: 122 year: 1995 ident: BIB14 publication-title: J. Am. Chem. Soc. contributor: fullname: Brungs – volume: 36 start-page: 314 year: 1993 ident: BIB18 publication-title: J. Med. Chem. contributor: fullname: Gesellchen – volume: 267 start-page: 7911 year: 1992 ident: BIB8 publication-title: J. Biol. Chem. contributor: fullname: Edwards – volume: 3 start-page: 357 year: 1990 ident: BIB3 publication-title: Drug News Perspect. contributor: fullname: Butler – volume: 3 start-page: 1025 year: 1995 ident: BIB13 publication-title: Bioorg. Med. Chem. contributor: fullname: Andrade-Gordon – volume: 5 start-page: 825 year: 1996 ident: BIB19 publication-title: Protein Sci. contributor: fullname: Tulinsky – volume: 221 start-page: 583 year: 1991 ident: BIB20 publication-title: J. Mol. Biol. contributor: fullname: Maraganore – volume: 3 start-page: 999 year: 1995 ident: BIB4 publication-title: Bioorg. Med. Chem. contributor: fullname: Kimball – ident: BIB17 – volume: 30 start-page: 10363 year: 1991 ident: BIB2 publication-title: Biochemistry contributor: fullname: Kisiel – volume: 1 start-page: 426 year: 1992 ident: BIB9 publication-title: Protein Sci. contributor: fullname: Karshikov – ident: BIB15 – volume: 30 start-page: 10363 year: 1991 ident: 10.1016/S0960-894X(96)00554-9_BIB2 publication-title: Biochemistry doi: 10.1021/bi00107a001 contributor: fullname: Davie – volume: 261 start-page: 546 year: 1992 ident: 10.1016/S0960-894X(96)00554-9_BIB16 publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Jackson – volume: 5 start-page: 825 year: 1996 ident: 10.1016/S0960-894X(96)00554-9_BIB19 publication-title: Protein Sci. doi: 10.1002/pro.5560050504 contributor: fullname: Ganesh – volume: 36 start-page: 314 year: 1993 ident: 10.1016/S0960-894X(96)00554-9_BIB18 publication-title: J. Med. Chem. doi: 10.1021/jm00055a002 contributor: fullname: Shuman – volume: 8 start-page: 3467 year: 1989 ident: 10.1016/S0960-894X(96)00554-9_BIB10 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1989.tb08511.x contributor: fullname: Bode – volume: 1 start-page: 441 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB6 publication-title: Curr. Pharm. Design contributor: fullname: Kimball – volume: 117 start-page: 122 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB14 publication-title: J. Am. Chem. Soc. contributor: fullname: Maryanoff – volume: 30 start-page: 71 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB5 publication-title: Annu. Rep. Med. Chem. doi: 10.1016/S0065-7743(08)60921-5 contributor: fullname: Scarborough – volume: 267 start-page: 7911 year: 1992 ident: 10.1016/S0960-894X(96)00554-9_BIB8 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)42599-9 contributor: fullname: Martin – volume: 90 start-page: 8048 year: 1993 ident: 10.1016/S0960-894X(96)00554-9_BIB12 contributor: fullname: Maryanoff – volume: 3 start-page: 999 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB4 publication-title: Bioorg. Med. Chem. doi: 10.1016/0968-0896(95)00104-O contributor: fullname: Das – volume: 1 start-page: 426 year: 1992 ident: 10.1016/S0960-894X(96)00554-9_BIB9 publication-title: Protein Sci. doi: 10.1002/pro.5560010402 contributor: fullname: Bode – volume: 3 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB11 – volume: 221 start-page: 583 year: 1991 ident: 10.1016/S0960-894X(96)00554-9_BIB20 publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(91)80074-5 contributor: fullname: Skrzypczak-Jankun – start-page: 63 year: 1992 ident: 10.1016/S0960-894X(96)00554-9_BIB7 article-title: Thrombin: Structure and Function – volume: 3 start-page: 1025 year: 1995 ident: 10.1016/S0960-894X(96)00554-9_BIB13 publication-title: Bioorg. Med. Chem. doi: 10.1016/0968-0896(95)00098-2 contributor: fullname: Maryanoff – volume: 3 start-page: 357 year: 1990 ident: 10.1016/S0960-894X(96)00554-9_BIB3 publication-title: Drug News Perspect. contributor: fullname: Talbot – year: 1992 ident: 10.1016/S0960-894X(96)00554-9_BIB1 article-title: Thrombin: Structure and Function |
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