CD8 + PD-1 - ILT2 + T Cells Are an Intratumoral Cytotoxic Population Selectively Inhibited by the Immune-Checkpoint HLA-G

• Published in: Cancer immunology research Vol. 7; no. 10; p. 1619
• Main Authors: Dumont, Clement, Jacquier, Alix, Verine, Jerome, Noel, Floriane, Goujon, Annabelle, Wu, Ching-Lien, Hung, Tzu-Min, Desgrandchamps, François, Culine, Stephane, Carosella, Edgardo D, Rouas-Freiss, Nathalie, LeMaoult, Joel
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019

Only some cancer patients respond to the immune-checkpoint inhibitors being used in the clinic, and other therapeutic targets are sought. Here, we investigated the HLA-G/ILT2 checkpoint in clear-cell renal-cell carcinoma (ccRCC) patients and focused on tumor-infiltrating CD8 T lymphocytes (TIL) expr...