Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 23; pp. 5986 - 5998
• Main Authors: Muralidhar, Sathya, Filia, Anastasia, Nsengimana, Jérémie, Poźniak, Joanna, O'Shea, Sally J., Diaz, Joey M., Harland, Mark, Randerson-Moor, Juliette A., Reichrath, Jörg, Laye, Jonathan P., van der Weyden, Louise, Adams, David J., Bishop, D.T., Newton-Bishop, Julia
• Format: Journal Article
• Language: English
• Published: United States 01.12.2019
• Subjects: Animals; beta Catenin - metabolism; Calcitriol - blood; Calcitriol - deficiency; Cell Line, Tumor; Datasets as Topic; Disease Progression; Female; Humans; Lymphocytes, Tumor-Infiltrating - immunology; Male; Melanoma - blood; Melanoma - immunology; Melanoma - mortality; Melanoma - pathology; Mice; Receptors, Calcitriol - metabolism; Skin - metabolism; Skin Neoplasms - blood; Skin Neoplasms - immunology; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Survival Analysis; Time Factors; Vitamin D Deficiency - blood; Vitamin D Deficiency - immunology; Vitamin D Deficiency - pathology; Wnt Signaling Pathway

1α,25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As patients with melanoma commonly avoid sun exposure, and consequent vitamin D deficiency...