Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity

• Published in: Anticancer research Vol. 41; no. 5; pp. 2321 - 2331
• Main Authors: CHEN, YI-FAN, WANG, CHUNG-CHI, HSU, CHIEH-YING, HUANG, ENG-YEN
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.05.2021
• Subjects: Antibodies; Antigens; Cancer therapies; Cells; Extracellular matrix; Galectin-1; Immunohistochemistry; Irradiation; Laboratory animals; Lung cancer; Lymphocytes; Lymphocytes B; Lymphocytes T; Melanoma; Radiation; Radiation tolerance; Radioresistance; Radiosensitivity; Radiosensitization; Tumor microenvironment; Tumors; Viral infections; United States > US; Taiwan; Galectin-1; radiosensitivity; tumor microenvironment

The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tu...