Splenectomy as a Risk Factor for Graft Rejection Following Endothelial Transplantation: Retrospective Study

• Published in: Interactive journal of medical research Vol. 13; p. e50106
• Main Authors: Kammrath Betancor, Paola, Böhringer, Daniel, Maier, Philip, Lapp, Thabo, Reinhard, Thomas
• Format: Journal Article
• Language: English
• Published: Canada JMIR Publications 10.09.2024
• Subjects: Original Paper; ACAID; Descemet membrane endothelial keratoplasty; anterior chamber–associated immune deviation; splenectomy; DMEK

Anterior chamber-associated immune deviation (ACAID) is an active immunotolerance mechanism, which is induced by placing antigen into the anterior eye chamber as long as a major surgical trauma is avoided. For this reason, ACAID may be a major contributor to the favorable immunologic outcomes in Des...