Small-world brain networks in schizophrenia
Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the...
Saved in:
| Published in | Shanghai Jingshen Yixue Vol. 24; no. 6; pp. 322 - 327 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
China
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China%Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China
01.12.2012
Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Editorial Department of the Shanghai Archives of Psychiatry |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1002-0829 |
| DOI | 10.3969/j.issn.1002-0829.2012.06.003 |
Cover
| Abstract | Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks – called ‘small-world brain networks＇– and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research. |
|---|---|
| AbstractList | Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks - called 'small-world brain networks' - and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research.SUMMARYOver the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks - called 'small-world brain networks' - and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research. Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks – called ‘small-world brain networks＇– and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research. Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks - called 'small-world brain networks' - and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research. |
| Author | 李名立 陈壮飞 李涛 |
| AuthorAffiliation | Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Faculty of Medicine, Kunming University of Science and Technology |
| AuthorAffiliation_xml | – name: Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China;State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China%Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China – name: 3 Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China – name: 1 Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China – name: 2 State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China |
| Author_xml | – sequence: 1 fullname: 李名立 陈壮飞 李涛 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25324636$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUFtLwzAYzcPEzbm_IBMEBWn9krRZ8yLI8AaCD-pzSNp0zWyTrdmc89ebsQv6dL7L4ZzDOUEd66xG6AJDTDnjN9PYeG9jDEAiyAiPCWASA4sBaAf1DvcuGnhvFGDMgWNCjlGXpJQkjLIeun5rZF1HK9fWxVC10tih1YuwfvphmH1emR83q1ptjTxFR6WsvR7ssI8-Hu7fx0_Ry-vj8_juJcoJ5TTieCRJqijFWRkgJRgSQrFKacqUYimBgo8K4CrJCkxVnkOq9KjMygyKEidA--h2qztbqkYXubaLVtZi1ppGtmvhpBH_P9ZUYuK-RIJ5lvEsCFxuBVbSltJOxNQtWxsiC19N_fp7UxSwUFNgXu2sWjdfar8QjfG5rmtptVt6gRmmPAGeblKd_U11iLPvMhDOt4S8cnYyN8F3z0kShoFzoL8vRIP8 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright © 2012 by Editorial Department of the Shanghai Archives of Psychiatry 2012 |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. – notice: Copyright © 2012 by Editorial Department of the Shanghai Archives of Psychiatry 2012 |
| DBID | 2RA 92L CQIGP W91 ~WA NPM 7X8 2B. 4A8 92I 93N PSX TCJ 5PM |
| DOI | 10.3969/j.issn.1002-0829.2012.06.003 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 PubMed MEDLINE - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Small-world brain networks in schizophrenia |
| EndPage | 327 |
| ExternalDocumentID | PMC4198898 shjsyx201206003 25324636 44610990 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: This work was partly supported by National Natural Science Foundation of China; the National Basic Research Program of China; the PhD Programs Foundation of the Ministry of Education of China; National Key Technology R & D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan funderid: (81130024,30530300 and 30125014,TL); (973 Program 2007CB512301,TL); (20110181110014,TL); (2011BAZ02530,TL) |
| GroupedDBID | -05 -SE 2B. 2C~ 2RA 5VS 5XA 5XF 92F 92I 92L ABDBF ACGFS ACMMV ADRAZ ALMA_UNASSIGNED_HOLDINGS CAJEE CCEZO CIEJG CQIGP CW9 EOJEC ESX GROUPED_DOAJ HYE IAO IHR IPNFZ KQ8 M48 OBODZ OK1 RIG RNS RPM TCJ TGQ U1G U5O W91 ~WA -S~ ABJNI NPM PGMZT 7X8 4A8 93N PSX 5PM |
| ID | FETCH-LOGICAL-c2393-917a25b3318f5b352104231b5356bb6520d97d09b48d13bcc05be7f8f80df1403 |
| IEDL.DBID | M48 |
| ISSN | 1002-0829 |
| IngestDate | Thu Aug 21 17:39:31 EDT 2025 Thu May 29 03:54:21 EDT 2025 Fri Jul 11 03:36:10 EDT 2025 Mon Jul 21 06:06:55 EDT 2025 Wed Feb 14 10:43:35 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 6 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2393-917a25b3318f5b352104231b5356bb6520d97d09b48d13bcc05be7f8f80df1403 |
| Notes | Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks – called ‘small-world brain networks＇– and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research. 31-1564/R Mingli LI 1,2 , Zhuangfei CHEN 3 , Tao LI 1,2 ＊1 Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China 2 State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China 3 Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3969/j.issn.1002-0829.2012.06.003 |
| PMID | 25324636 |
| PQID | 1613940950 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4198898 wanfang_journals_shjsyx201206003 proquest_miscellaneous_1613940950 pubmed_primary_25324636 chongqing_primary_44610990 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-12-00 |
| PublicationDateYYYYMMDD | 2012-12-01 |
| PublicationDate_xml | – month: 12 year: 2012 text: 2012-12-00 |
| PublicationDecade | 2010 |
| PublicationPlace | China |
| PublicationPlace_xml | – name: China |
| PublicationTitle | Shanghai Jingshen Yixue |
| PublicationTitleAlternate | Shanghai Archives of Psychiatry |
| PublicationTitle_FL | SHANGHAI ARCHIVES OF PSYCHIATRY |
| PublicationYear | 2012 |
| Publisher | State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China%Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Editorial Department of the Shanghai Archives of Psychiatry |
| Publisher_xml | – name: Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China – name: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China%Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunan Province, China – name: Editorial Department of the Shanghai Archives of Psychiatry |
| References | 18072237 - Hum Brain Mapp. 2009 Feb;30(2):403-16 16399673 - J Neurosci. 2006 Jan 4;26(1):63-72 20631176 - J Neurosci. 2010 Jul 14;30(28):9477-87 18784304 - J Neurosci. 2008 Sep 10;28(37):9239-48 21035793 - Biol Psychiatry. 2011 Jan 1;69(1):80-9 18448652 - J Neurosci. 2008 Apr 30;28(18):4756-66 21514570 - Biol Psychiatry. 2011 Jul 1;70(1):64-72 22457774 - PLoS One. 2012;7(3):e33540 20562318 - Cereb Cortex. 2011 Feb;21(2):449-58 15734358 - Neuroimage. 2005 Mar;25(1):230-42 18299296 - Brain. 2008 Apr;131(Pt 4):945-61 21369355 - Front Syst Neurosci. 2011 Feb 08;5:7 16678344 - Neurosci Lett. 2006 Jul 24;402(3):273-7 15698136 - Phys Rev Lett. 2005 Jan 14;94(1):018102 15635061 - Cereb Cortex. 2005 Sep;15(9):1332-42 15210971 - Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9849-54 20072616 - PLoS One. 2010 Jan 08;5(1):e8525 18219621 - Hum Brain Mapp. 2009 Feb;30(2):638-49 12948688 - Neuroimage. 2003 Aug;19(4):1273-302 20881136 - J Neurosci. 2010 Sep 29;30(39):13171-9 18064590 - Hum Brain Mapp. 2008 Dec;29(12):1368-78 19515930 - J Neurosci. 2009 Jun 10;29(23):7619-24 19190637 - Nat Rev Neurosci. 2009 Mar;10(3):186-98 9549774 - Schizophr Res. 1998 Mar 10;30(2):115-25 19494774 - Curr Opin Neurol. 2009 Aug;22(4):340-7 18649353 - Hum Brain Mapp. 2009 May;30(5):1511-23 21110988 - Neuropsychologia. 2011 Jan;49(2):254-63 10725185 - Neuroimage. 2000 Apr;11(4):289-301 21980454 - PLoS One. 2011;6(9):e25423 18565765 - Neuroimage. 2008 Aug 15;42(2):649-62 18567609 - Cereb Cortex. 2009 Mar;19(3):524-36 18234689 - Cereb Cortex. 2008 Aug;18(8):1737-47 21106830 - J Neurosci. 2010 Nov 24;30(47):15915-26 17204824 - Cereb Cortex. 2007 Oct;17(10):2407-19 17274684 - PLoS Comput Biol. 2007 Feb 2;3(2):e17 15219588 - Neuroimage. 2004 Jul;22(3):1157-72 22701611 - PLoS One. 2012;7(6):e38195 22387165 - Neuroimage. 2012 Oct 1;62(4):2296-314 14514495 - Am J Psychiatry. 2003 Oct;160(10):1809-16 16452642 - Cereb Cortex. 2007 Jan;17(1):92-9 18786642 - Neuroimage. 2008 Nov 15;43(3):528-39 18272400 - Neuroimage. 2008 Apr 15;40(3):1064-76 17079517 - Neuroscientist. 2006 Dec;12(6):512-23 21963918 - Neuroimage. 2012 Jan 16;59(2):1085-93 |
| References_xml | – reference: 21369355 - Front Syst Neurosci. 2011 Feb 08;5:7 – reference: 15210971 - Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9849-54 – reference: 16678344 - Neurosci Lett. 2006 Jul 24;402(3):273-7 – reference: 21980454 - PLoS One. 2011;6(9):e25423 – reference: 20631176 - J Neurosci. 2010 Jul 14;30(28):9477-87 – reference: 18219621 - Hum Brain Mapp. 2009 Feb;30(2):638-49 – reference: 18072237 - Hum Brain Mapp. 2009 Feb;30(2):403-16 – reference: 18649353 - Hum Brain Mapp. 2009 May;30(5):1511-23 – reference: 20072616 - PLoS One. 2010 Jan 08;5(1):e8525 – reference: 21035793 - Biol Psychiatry. 2011 Jan 1;69(1):80-9 – reference: 20881136 - J Neurosci. 2010 Sep 29;30(39):13171-9 – reference: 18786642 - Neuroimage. 2008 Nov 15;43(3):528-39 – reference: 16399673 - J Neurosci. 2006 Jan 4;26(1):63-72 – reference: 20562318 - Cereb Cortex. 2011 Feb;21(2):449-58 – reference: 22701611 - PLoS One. 2012;7(6):e38195 – reference: 12948688 - Neuroimage. 2003 Aug;19(4):1273-302 – reference: 17274684 - PLoS Comput Biol. 2007 Feb 2;3(2):e17 – reference: 17079517 - Neuroscientist. 2006 Dec;12(6):512-23 – reference: 18272400 - Neuroimage. 2008 Apr 15;40(3):1064-76 – reference: 16452642 - Cereb Cortex. 2007 Jan;17(1):92-9 – reference: 19515930 - J Neurosci. 2009 Jun 10;29(23):7619-24 – reference: 22387165 - Neuroimage. 2012 Oct 1;62(4):2296-314 – reference: 21963918 - Neuroimage. 2012 Jan 16;59(2):1085-93 – reference: 19494774 - Curr Opin Neurol. 2009 Aug;22(4):340-7 – reference: 14514495 - Am J Psychiatry. 2003 Oct;160(10):1809-16 – reference: 18064590 - Hum Brain Mapp. 2008 Dec;29(12):1368-78 – reference: 21514570 - Biol Psychiatry. 2011 Jul 1;70(1):64-72 – reference: 18784304 - J Neurosci. 2008 Sep 10;28(37):9239-48 – reference: 17204824 - Cereb Cortex. 2007 Oct;17(10):2407-19 – reference: 15219588 - Neuroimage. 2004 Jul;22(3):1157-72 – reference: 21110988 - Neuropsychologia. 2011 Jan;49(2):254-63 – reference: 15698136 - Phys Rev Lett. 2005 Jan 14;94(1):018102 – reference: 9549774 - Schizophr Res. 1998 Mar 10;30(2):115-25 – reference: 15635061 - Cereb Cortex. 2005 Sep;15(9):1332-42 – reference: 18299296 - Brain. 2008 Apr;131(Pt 4):945-61 – reference: 15734358 - Neuroimage. 2005 Mar;25(1):230-42 – reference: 22457774 - PLoS One. 2012;7(3):e33540 – reference: 10725185 - Neuroimage. 2000 Apr;11(4):289-301 – reference: 18448652 - J Neurosci. 2008 Apr 30;28(18):4756-66 – reference: 21106830 - J Neurosci. 2010 Nov 24;30(47):15915-26 – reference: 18565765 - Neuroimage. 2008 Aug 15;42(2):649-62 – reference: 19190637 - Nat Rev Neurosci. 2009 Mar;10(3):186-98 – reference: 18234689 - Cereb Cortex. 2008 Aug;18(8):1737-47 – reference: 18567609 - Cereb Cortex. 2009 Mar;19(3):524-36 |
| SSID | ssib011909122 ssib035549555 ssib038074728 ssib001103414 ssib051367929 ssib018830289 ssj0000744950 |
| Score | 1.5325801 |
| SecondaryResourceType | review_article |
| Snippet | Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the... |
| SourceID | pubmedcentral wanfang proquest pubmed chongqing |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 322 |
| SubjectTerms | Review 大脑 小世界 工作状态 患者 拓扑性质 精神分裂症 精神疾病 网络图 |
| Title | Small-world brain networks in schizophrenia |
| URI | http://lib.cqvip.com/qk/97872X/201206/44610990.html https://www.ncbi.nlm.nih.gov/pubmed/25324636 https://www.proquest.com/docview/1613940950 https://d.wanfangdata.com.cn/periodical/shjsyx201206003 https://pubmed.ncbi.nlm.nih.gov/PMC4198898 |
| Volume | 24 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1NS-UwFL2Ig-JmGPGrjkoFd1Jtm6RpFiIiigi6mXngriRt4lOeeWqV0X8_96Z9D0UFVy00beHk5n60J-cC7KBj1DnjNpG2YAnPZZoo7myincBoKRudZbTB-eKyOBvw8ytxNQMTWnMPYPtpaUf9pAaPo72Xh9dDXPAHVHGqQu3fhvUSxEQT2ipKhK08qHKSDOgPjFEFlWUXfeIffLTkWBl0UgX9XfOw850HknqwwCykYEGOYTj21w8YZD5LUD_yLOf-ae-0v34Twk5_wc8-94yPOmNZhBnrl2D3z50ejZKgnBobahgR-44a3sZ43r4l5S3D4PTk7_FZ0ndQSGqSNkNPJnUuDMOF6_CAoZpoMJkRTBTGFCJPGyWbVBleNhkzdZ0KY6UrXZk2jpT8VmDWj71dg7hMnVK1dlj_FBzdhHLMybJ2DROK19ZFsD4Fo7rvlDIqHtTcVRrB9gSdCs2X_klob8fPbYUJJ_Vmx7mIYLVDa3r3BOcI5DscpwNIGvv9FX8zDBLZPFNlqcoI4h7xamJZVTu8bV9faEZTTPbY-pev_Q0LNKrjrmzA7NPjs93EDOTJbAVj2gqfhv4DbwDT0Q |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Small-world+brain+networks+in+schizophrenia&rft.jtitle=Shanghai+Jingshen+Yixue&rft.au=Li%2C+Mingli&rft.au=Chen%2C+Zhuangfei&rft.au=Li%2C+Tao&rft.date=2012-12-01&rft.issn=1002-0829&rft.volume=24&rft.issue=6&rft.spage=322&rft_id=info:doi/10.3969%2Fj.issn.1002-0829.2012.06.003&rft_id=info%3Apmid%2F25324636&rft.externalDocID=25324636 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F97872X%2F97872X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fshjsyx%2Fshjsyx.jpg |