Real-time analysis of the biomolecular interaction between gelsolin and Aβ1-42 monomer and its implication for Alzheimer's disease

• Published in: Talanta (Oxford) Vol. 282; p. 126938
• Main Authors: Ma, Limin, Meng, Tian, Wang, Yu, Xue, Yu, Zheng, Yuxin, Chen, Jinghuang, Xu, Dongming, Sun, Jian, Yang, Fan, Huang, Jianshe, Yang, Xiurong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2025
• Subjects: Alzheimer disease; Alzheimer's disease; Amyloid beta-peptides; cerebrospinal fluid; circular dichroism spectroscopy; Dual polarization interferometry; interferometry; kinetics; Molecular docking; molecular dynamics; Protein-protein interactions; solubilization; species; therapeutics; Dual polarization interferometry; Amyloid beta-peptides; Alzheimer's disease; Protein-protein interactions; Molecular docking

Biomolecular interaction acts a pivotal part in understanding the mechanisms underlying the development of Alzheimer's disease (AD). Herein, we built a biosensing platform to explore the interaction between gelsolin (GSN) and different β-amyloid protein 1-42 (Aβ1-42) species, including Aβ1-42 m...