Preventive effects of autologous bone marrow mononuclear cell implantation on intrahepatic ischemic-type biliary lesion in rabbits

• Published in: Hepatobiliary & pancreatic diseases international Vol. 9; no. 6; pp. 593 - 599
• Main Authors: Qu, Zhao-Wei, Chen, Da-Zhi, Sheng, Qin-Song, Lang, Ren, He, Qiang, Wang, Ming-Feng
• Format: Journal Article
• Language: English
• Published: Singapore 01.12.2010
• Subjects: angiogenesis; Animals; bile; Bile Ducts, Intrahepatic - pathology; biliary; bone; Bone Marrow Cells - cytology; Bone Marrow Transplantation - methods; cell; Cell Differentiation - physiology; duct; Endothelial Cells - cytology; Female; intrahepatic; Ischemia - pathology; Ischemia - therapy; ischemic-type; lesion; liver; Liver Transplantation - adverse effects; Male; marrow; mononuclear; Neovascularization, Physiologic - physiology; Postoperative Complications - pathology; Postoperative Complications - prevention & control; Postoperative Complications - therapy; Rabbits; Survival Rate; transplantation; Transplantation, Autologous

BACKGROUND:The ischemic-type biliary lesion(ITBL)is one of the most serious biliary complications of liver transplantation. This study aimed to investigate the effects of autologous bone marrow mononuclear cell(BM-MNC)implantation on neovascularization and the prevention of intrahepatic ITBL in a ra...