Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial

• Published in: Diabetes care Vol. 47; no. 8; pp. 1441 - 1448
• Main Authors: Ware, Julia, Boughton, Charlotte K, Allen, Janet M, Wilinska, Malgorzata E, Hartnell, Sara, Thankamony, Ajay, Randell, Tabitha, Ghatak, Atrayee, Besser, Rachel E J, Elleri, Daniela, Trevelyan, Nicola, Campbell, Fiona M, Sibayan, Judy, Bailey, Ryan, Calhoun, Peter, Dunseath, Gareth, Hovorka, Roman
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.08.2024
• Subjects: Adolescent; Algorithms; Blood Glucose - drug effects; Blood Glucose - metabolism; C-Peptide - blood; Child; Closed loops; Design standards; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Diagnosis; Fasting; Female; Glucose; Glycated Hemoglobin - metabolism; Glycemic Control - methods; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - administration & dosage; Insulin - therapeutic use; Insulin Infusion Systems; Ketoacidosis; Male; Peptides; Randomization; Research design; Secretion; Therapy

We evaluated the effect of long-term intensive metabolic control with hybrid closed-loop (CL) on residual C-peptide secretion and glucose control compared with standard insulin therapy in youth with type 1 diabetes over 48 months. Following the 24-month primary phase of a multicenter, randomized, pa...