Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis

• Published in: Journal of traditional Chinese medicine Vol. 35; no. 1; pp. 63 - 68
• Main Authors: Yang, Lihua, Wang, Yun, Wang, Xiaohua, Liu, Yanqing
• Format: Journal Article
• Language: English
• Published: China 01.02.2015
• Subjects: Alanine Transaminase - genetics; Alanine Transaminase - metabolism; Albumins - genetics; Albumins - metabolism; Animals; Cell- and Tissue-Based Therapy; Disease Models, Animal; Female; Humans; Keratin-18 - genetics; Keratin-18 - metabolism; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver Cirrhosis - therapy; Mesenchymal Stem Cell Transplantation; Rats; Rats, Sprague-Dawley; Transplantation, Homologous; Umbilical Cord - cytology; Umbilical Cord - metabolism; Umbilical Cord - transplantation; Western印迹; 丙氨酸转氨酶; 反转录聚合酶链反应; 大鼠模型; 干细胞移植; 肝硬化; 脐带; 间充质干细胞

OBJECTIVE：To determine the effects of human umbilical cord mesenchymal stem cell （UCMSC） transplantation, alone or in combination with tanshi- none IIA （Tan ⅡA） on hepatic cirrhosis in rats. METHODS： A rat model of cirrhosis was established. Rats were divided into control, UCMSC, and UCSMC plus Tan...