HEPATOCELLULAR CARCINOMA IN A YOUNG WOMAN WHICH OCCURED IN THE LIVER WITHOUT VIRUS INFECTION

A 31-year-old woman who was accidentally detected having a hepatic tumor at a medical checkup was admitted to our hospital for further exploration and treatment. Abdominal CT and magnetic resonance imaging scans visualized a tumor with the maximum diameter of about 5 cm in the S5 area of the liver....

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Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 65; no. 7; pp. 1918 - 1923
Main Authors SANADA, Hiroaki, SUEDA, Taijiro, NAKAI, Shiro, FUJIMOTO, Mikio, SANTO, Takahiro, MIYAMOTO, Katsunari, SHIMAMOTO, Fumio
Format Journal Article
LanguageEnglish
Published Japan Surgical Association 2004
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Abstract A 31-year-old woman who was accidentally detected having a hepatic tumor at a medical checkup was admitted to our hospital for further exploration and treatment. Abdominal CT and magnetic resonance imaging scans visualized a tumor with the maximum diameter of about 5 cm in the S5 area of the liver. The hepatic tumor was removed under laparotomy. Histological diagnosis was hepatocellular carcinoma arisen in liver cell adenoma. On hematological studies conducted before surgery, hepatitis virus marker was negative, and all tumor markers including α-fetoprotein, PIVKA-II, and CA19-9 were also negative. The patient has been free from recurrence as of 2 years 7 months after the surgery. Although juvenile onset of hepatocellular carcinoma lacking any background risk factors is rare, we can actually encounter it. Consequently a possibility of malignancy must usually be kept in mind in diagnosing hepatic tumors in young people. Furthermore this case showed so rare morphology that hepatocellular carcinoma had arisen from liver cell adenoma, and no such cases have been reported in Japan. This paper presents the case together with bibliographical comments.
AbstractList A 31-year-old woman who was accidentally detected having a hepatic tumor at a medical checkup was admitted to our hospital for further exploration and treatment. Abdominal CT and magnetic resonance imaging scans visualized a tumor with the maximum diameter of about 5 cm in the S5 area of the liver. The hepatic tumor was removed under laparotomy. Histological diagnosis was hepatocellular carcinoma arisen in liver cell adenoma. On hematological studies conducted before surgery, hepatitis virus marker was negative, and all tumor markers including α-fetoprotein, PIVKA-II, and CA19-9 were also negative. The patient has been free from recurrence as of 2 years 7 months after the surgery. Although juvenile onset of hepatocellular carcinoma lacking any background risk factors is rare, we can actually encounter it. Consequently a possibility of malignancy must usually be kept in mind in diagnosing hepatic tumors in young people. Furthermore this case showed so rare morphology that hepatocellular carcinoma had arisen from liver cell adenoma, and no such cases have been reported in Japan. This paper presents the case together with bibliographical comments.
Author MIYAMOTO, Katsunari
NAKAI, Shiro
SUEDA, Taijiro
SANTO, Takahiro
FUJIMOTO, Mikio
SHIMAMOTO, Fumio
SANADA, Hiroaki
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  fullname: SUEDA, Taijiro
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  fullname: NAKAI, Shiro
  organization: Department of Surgery, Hiroshima Memorial Hospital
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  fullname: FUJIMOTO, Mikio
  organization: Department of Surgery, Hiroshima Memorial Hospital
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  fullname: SANTO, Takahiro
  organization: Department of Surgery, Hiroshima Memorial Hospital
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  fullname: MIYAMOTO, Katsunari
  organization: Department of Surgery, Hiroshima Memorial Hospital
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  fullname: SHIMAMOTO, Fumio
  organization: Department of Pathology, School of Health Sciences, Hiroshima Women's University
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References 1) 川原 弘,高瀬修二郎:肝癌撲滅2000年への挑戦-非ウイルス性肝炎-.肝・胆・膵 39: 751-756, 1999
25) 四柳 宏,橋詰清江,鈴木通博他:非B非C型肝細胞癌におけるウイルスの関与.臨消内科 14: 840-846, 1999
20) Tagger A, Donato F, Ribro ML, et al: A case-control study on GB virus/hepatitis G virus infection and hepatocellular carcinoma. Hepatology 26: 1653-1657, 1997
21) 佐田通夫,古賀研志,小野尚文:非B非C型肝炎と肝細胞癌.肝・胆・膵 37: 221-227, 1998
23) Kobayashi S, Hayashi H, Itoh Y, et al: Detection of minus-strand hepatitis C virus RNA in tumor tissues of hepatocellular carcinoma. Cancer 73: 48-52, 1994
19) Sugai Y, Nakayama H, Fukuda M, et al: Infection with GB virus C in patients with chronic liver disease. J Med Virol 51: 175-181, 1997
17) International Working Party: Terminology of nodular hepatocellular lesions. Hepatology 22: 983-993, 1995
5) Farinati F, De Maria N, Naccarato R, et al: Hepatocelluler carcinoma in alcoholic cirrhosis: Is sex hormone imbalance a pathogenic factor? Euro J Gastroenterol Hepatol 7: 145-150, 1995
13) Guglielmi M, Perilongo G, Cecchetto G, et al: Rationale and result of the international society of pediatric oncology (SIOP) Italian pilot study of childhood hematoma; Surgical resection d'emblee or after primary chemotherapy? J Surg Oncol Suppl 3: 122-126, 1993
10) 中野道子,大塚幸夫,菅谷 仁他:急激な経過をたどった血中肝炎ウイルスマーカー陰性の若年発症肝細胞癌の1例. Dokkyo J Med Sci 29: 177-181, 2002
4) Bloom PD, Gordeuk VR, Macphail AP: HLA-linked hemochromatosis and other forms of iron overload. Dermatol Clin 13: 57-63, 1995
8) Kosaka A, Takahashi H, Katsuta K, et al: Hepatocelluler carcinoma associated with anabolic steroid therapy: report of a case and review of the Japanese literature. J Gastroenterol 31: 450-454, 1996
18) Ishak KG, Goodman ZD, Thomas Stocker J: Tumor of the liver and intrahepatic bile ducts. Ed. by Rosai J, Atlas of tumor pathology, Armed Forces institute of pathology, Washington, 2001, p10-23
7) Farinati F, Floreani A, Chiaramonte M, et al: Hepatocelluler carcinoma in primary billiary cirrhosis. J Hepatol 21: 315-316, 1994
15) 近藤 敏,瀬川 徹,一瀬浩郎他:若年者肝細胞癌症例の検討.日消外会誌 24: 1196-1200, 1991
3) 日本肝癌研究会:原発性肝癌に関する追跡調査-第13報-.肝臓 40: 288-300, 1999
12) 中力美和,猪飼伊和夫,山本正之他:肝炎既往のない若年者肝細胞癌の1例.日消外会誌 30: 2292-2296, 1997
2) 日本肝癌研究会肝癌追跡調査委員会:第15回全国原発性肝癌追跡調査報告.日本肝癌研究会事務局,京都, 2002, p38
6) Tavani A, Negri E, La Vecchia C, et al: Female hormone utilization and risk of hepatocelluler carcinoma. Br J Cancer 67: 635-637, 1993
11) 野口 修,泉 並木,櫻井 馨他:非ウイルス性肝障害合併肝細胞癌における局所治療の意義.医と薬学 46: 508-510, 2001
24) De Mitri MS, Poussin K, Baccarini P, et al: HCV-associated liver cancer without cirrhosis. Lancet 345: 413-415, 1995
9) Collier JD, Curless R, Bassendine MF, et al: Clinical feature and prognosis of hepatocelluler carcinoma in Britain in relation to age. Age and Aging 23: 22-27, 1994
14) Namieno T, Kawata A, Satou N, et al: Age related, different clinicopathologic feature of hepatocellular carcinoma patients. Ann Surg 221: 308-314, 1995
16) 堀江 靖,加藤雅子:若年者に生じた悪性肝腫瘍の2例: Fibrolamellar Hepatocellular CarcinomaとEpithelioid Hemangioendothelioma.岡山外科病理誌 37: 27-34, 2000
22) 近藤艶枝,野中 卓,堀池典生他: Reverse transcriptase polymerase chain (RT-PCR)による肝組織内(-)鎖HCV RNAの検出.臨病理 41: 919-922, 1993
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Title HEPATOCELLULAR CARCINOMA IN A YOUNG WOMAN WHICH OCCURED IN THE LIVER WITHOUT VIRUS INFECTION
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