Preparation and in vivo characterization of dual release tablet containing sarpogrelate hydrochloride

• Published in: Journal of pharmaceutical investigation Vol. 48; no. 3; pp. 363 - 372
• Main Authors: Jun, Hun, Lee, Hyo-Jung, Shin, Beom-Soo, Park, Chun-Woong
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.05.2018; 한국약제학회
• Subjects: Biomedical and Life Sciences; Biomedicine; Original Article; 약학; Dual release tablet; Pharmacokinetics; Sarpogrelate; In vitro–in vivo correlation

The aim of the present study was to prepare and evaluate the once-a-day dual release tablets of sarpogrelate and to perform in vitro and in vivo characterization. Carboxymethylcellulose calcium and cellulose-derived polymer were used as release modifier in immediate release (IR) and extended release...