Effect of Preoperative Recombinant Human Erythropoietin on the Need for Blood Transfusion and Surgical Outcomes in Adult Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

• Published in: Journal of cardiothoracic and vascular anesthesia Vol. 38; no. 10; pp. 2402 - 2411
• Main Authors: Hakim, Sameh M., Ahmad, Aya Hisham Moussa, Amer, Akram M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2024
• Subjects: Adult; anemia; Blood Transfusion - statistics & numerical data; cardiac surgery; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; Cardiac Surgical Procedures - statistics & numerical data; erythropoiesis-stimulating agents; Erythropoietin - administration & dosage; Humans; open-heart surgery; Preoperative Care - methods; Randomized Controlled Trials as Topic - methods; recombinant human erythropoietin; Recombinant Proteins - administration & dosage; rhEPO; Treatment Outcome; rhEPO; cardiac surgery; open-heart surgery; recombinant human erythropoietin; anemia; erythropoiesis-stimulating agents

This study aimed to examine the value of preoperative recombinant human erythropoietin (rhEPO) administration to adults undergoing elective cardiac surgery. Databases were searched for randomized controlled trials (RCTs) comparing rhEPO plus standard treatment versus standard treatment only. Primary...