Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation
The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 (p<0.05), IL-2 (p<0.05), and TNF-α (p<0.05), lactate (p<0.05), and nerv...
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| Published in | Bangladesh Journal of Pharmacology Vol. 17; no. 2 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bangladesh Pharmacological Society
16.06.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 (p<0.05), IL-2 (p<0.05), and TNF-α (p<0.05), lactate (p<0.05), and nerve growth factor (p<0.05) were found in the medroxyprogesterone-treated group by biochemical analysis. In histopathological examination, the medroxyprogesterone-treated group revealed significant improvement in neural body degeneration, neural count, and dysmorphological changes in both CA1 and CA3 regions. Immunohistochemical examination revealed improvement in glial activity with glial fibrillar acidic protein and morphological changes in Purkinje cells. Magnetic resonance spectroscopy showed an improvement in the level of lactate duplets in the medroxyprogesterone-treated group. To our knowledge, this is the first study, to evaluate the protective effect of medroxyprogesterone on propionic acid-induced autism in rats. |
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| AbstractList | The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 (p<0.05), IL-2 (p<0.05), and TNF-α (p<0.05), lactate (p<0.05), and nerve growth factor (p<0.05) were found in the medroxyprogesterone-treated group by biochemical analysis. In histopathological examination, the medroxyprogesterone-treated group revealed significant improvement in neural body degeneration, neural count, and dysmorphological changes in both CA1 and CA3 regions. Immunohistochemical examination revealed improvement in glial activity with glial fibrillar acidic protein and morphological changes in Purkinje cells. Magnetic resonance spectroscopy showed an improvement in the level of lactate duplets in the medroxyprogesterone-treated group. To our knowledge, this is the first study, to evaluate the protective effect of medroxyprogesterone on propionic acid-induced autism in rats. |
| Author | Muhammad Nasir Bhaya Mehmet Fatih Bozkurt Oytun Erbaş İbrahim Halil Sever Bahattin Özkul |
| Author_xml | – sequence: 1 fullname: Mehmet Fatih Bozkurt organization: Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey – sequence: 2 fullname: Muhammad Nasir Bhaya organization: Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey – sequence: 3 fullname: İbrahim Halil Sever organization: Department of Radiology, Demiroğlu Bilim University, Istanbul, Turkey – sequence: 4 fullname: Bahattin Özkul organization: Department of Radiology, Istanbul Atlas University, Istanbul, Turkey – sequence: 5 fullname: Oytun Erbaş organization: Department of Physiology, Cephalink Institute, Demiroğlu Bilim University, Gebze, Turkey |
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| Snippet | The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three... |
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| SubjectTerms | Autism; Medroxyprogesterone acetate; Propionic acid; GFAP; Rat; MR spectroscopy |
| Title | Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation |
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