Identification of daurisoline metabolites in rats via the UHPLC-Q-exactive orbitrap mass spectrometer

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 252; p. 116482
• Main Authors: Cai, Ruijun, Liu, Jing, Wang, Xuefang, An, Tao, Zhang, Ling
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.01.2025
• Subjects: Daurisoline; Metabolites; Sprague-Dawley rats; UHPLC-Q-Exactive Orbitrap MS; Vivo; Sprague-Dawley rats; Metabolites; Vivo; Daurisoline; UHPLC-Q-Exactive Orbitrap MS

Daurisoline, a bisbenzylisoquinoline alkaloid extracted from the rhizomes of Menispermum dauricum, exhibits diverse biological activities, encompassing antiplatelet, anti-inflammatory, neuroprotective, and antitumor properties. However, previous investigations have not comprehensively elucidated the...