Physicochemical and biopharmaceutical characterization of new sulfonamide derivatives of gallic acid

• Published in: British Journal of Pharmacy Vol. 7; no. 2; pp. S1 - S2
• Main Authors: Alhyari, Dania Hussein, Sheldrake, Helen Sheldrake, Kantamneni, Sriharsha, Isreb, Mohammad, Soumehsaraei, Shohreh Jafarinejad, Martin, William, Qinna, Nidal, Paluch, Krzysztof
• Format: Journal Article
• Language: English
• Published: Huddersfield, United Kingdom University of Huddersfield Press 01.11.2022
• Subjects: Analysis; Antioxidants; cyp2d6; Gallic acid; Measurement; Mescaline; Permeability; thbs; tmbs

Gallic acid (GA) is known for its antioxidant activity which is restricted due to its low oral permeability. In this project the carboxylic group of (GA) was substituted with sulfonamide group and hydroxyl groups were methylated which resulted in significantly (p<0.01) increased permeability of 3...