The potency (ED50) and cardiovascular effects of rapacuronium (Org 9487) during narcotic-nitrous oxide-propofol anesthesia in neonates, infants, and children

• Published in: Anesthesia and analgesia Vol. 89; no. 5; pp. 1172 - 1176
• Main Authors: KAPLAN, R. F, FLETCHER, J. E, HANNALLAH, R. S, BUI, D. T, SLAVEN, J. S, DARROW, E. J, TSAI, K.-T
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.11.1999
• Subjects: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Blood Pressure - drug effects; Child; Child, Preschool; Dose-Response Relationship, Drug; Heart Rate - drug effects; Histamine Release - drug effects; Humans; Infant; Infant, Newborn; Medical sciences; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents - administration & dosage; Neuropharmacology; Nitrous Oxide; Pharmacology. Drug treatments; Propofol; Prospective Studies; Vecuronium Bromide - administration & dosage; Vecuronium Bromide - analogs & derivatives; Human; Fentanyl; General anesthesia; Infant; Opiates; Narcotic analgesic; Rapacuronium bromide; Dose activity relation; Gases; Histamine; Non depolarisant myorelaxant; Newborn; General anesthetic; Hemodynamics; Propofol; Nitrogen protoxide; Child; Neuromuscular blocking; Release

We studied the neuromuscular blocking effects of rapacuronium (Org 9487) (dose-response curve, onset, and 50% effective dose [ED50] value), and changes in heart rate and blood pressure, as well as evidence of histamine release in neonates, infants, and children in an open-label, randomized, two-cent...