The usefulness of 99mTc-PMT hepatobiliary scintigraphy for the diagnosis of hepatic tumor lesions
Hepatobiliary scintigraphy using 99mTc-pyridoxyl-methyltriptophan was employed 47 patients with hepatocellular carcinoma (HCC) and 31 patients with other tumor lesions in the liver to evaluate the usefulness of this method for the diagnosis of hepatic tumor lesions. As positive images were obtained...
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| Published in | Kanzo Vol. 28; no. 4; pp. 451 - 458 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
1987
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.28.451 |
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| Abstract | Hepatobiliary scintigraphy using 99mTc-pyridoxyl-methyltriptophan was employed 47 patients with hepatocellular carcinoma (HCC) and 31 patients with other tumor lesions in the liver to evaluate the usefulness of this method for the diagnosis of hepatic tumor lesions. As positive images were obtained in 28 out of 47 patients with HCC and none of those with other hepatic tumor lesions, the sensitivity and specificity for the diagnosis of HCC were 59.5% and 100.0% respectively. Classifying HCC into three types, nodular, massive and diffuse, the positive tumor's image was obtained 74.0%, most frequently in the nodular type, 83.3% in the smaller than 3 cm and 66.7% in the larger than 3 cm in diameter respectively. As for massive and diffuse type, the positive rates were 53.8% and 14.2% respectively. Therefore, this imaging method seems to be clinically useful especially for the diagnosis of HCC in the early stage. |
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| AbstractList | Hepatobiliary scintigraphy using 99mTc-pyridoxyl-methyltriptophan was employed 47 patients with hepatocellular carcinoma (HCC) and 31 patients with other tumor lesions in the liver to evaluate the usefulness of this method for the diagnosis of hepatic tumor lesions. As positive images were obtained in 28 out of 47 patients with HCC and none of those with other hepatic tumor lesions, the sensitivity and specificity for the diagnosis of HCC were 59.5% and 100.0% respectively. Classifying HCC into three types, nodular, massive and diffuse, the positive tumor's image was obtained 74.0%, most frequently in the nodular type, 83.3% in the smaller than 3 cm and 66.7% in the larger than 3 cm in diameter respectively. As for massive and diffuse type, the positive rates were 53.8% and 14.2% respectively. Therefore, this imaging method seems to be clinically useful especially for the diagnosis of HCC in the early stage. |
| Author | TAKEDA, Isao MIYAZAWA, Yuji KUMADA, Takashi NAKANO, Satoshi SOBAVIMA, Yuji SHINDO, Jyo KIRIYAMA, Seiki KOZAWA, Hiroshi |
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| References | 8) Hasegawa Y, N akano S, Ibuka K:The importance of delayed imaging in the study of hepatoma with a new hepatobiliary agent. J Nucl Med 25:1122-1126, 1984 1) Victor WL, Michael JO, Dennis FD: Hepatocellular carcinoma:Uptake of 99mTcIDA in primary tumor and metastasis. AJR 143:57-61, 1984 10) 吉田宏,金森勇雄,中野哲,他:99mTc-Npyridoxy1-5-methyltryptophan (99mTc-PMT)による肝・胆道シンチグラフィーの基礎的および臨床的検討.Radioisotopes 32:340-343, 1983 3) Utz AJ, Lull RJ, Andersion JH: Hepatoma visualization with 99mTc-pyridoxylidene glutamate-J Nucl Med 21:747, 1980 11) 中野哲,熊田卓,太田博郷,他:細小肝細胞癌の臨床的研究.肝臓 23:782-791,1982 6) 長谷川義尚,中野俊一,野口敦司,他:肝細胞癌の診断における9emTc-(SN)-N-pyridoxy1-5-methyl-tryptophan〔99mTc-PMT〕の臨床的評価.核医学20:1355, 1983 5) Savitch I, Kew MC, Paterson A: Uptake of 99mTc-di-isopropyliminodiacetic acid by hepatocellular carcinoma. Concise communication. J Nucl Med 24:1119, 1983 12)中野哲,熊田 卓:肝癌診断法の進歩一血清ferritinの価値一.肝胆膵 5:1029-1034, 1982 13) Hasegawa Y, Nakano S, Ibuka K: Concentration of 99mTc-(SN)-N-pyridoxy1-5-methyltryptophan, a biliary agent, in distant metastases df hepatomas. Eur J Nucl Med 10: 255-258, 1985 2) Shoop JD: Functional hepatoma demonstrated with rose bengal scanning. Amr J Roentgenol lO7:51, 1969 7) 柏木徹,東正洋,松田裕之,他:肝細胞癌における99mTc-N-pyridoxy1-5-methyltryptophan肝胆道シンチグラフィーの診断的意義.日消誌82(9):2061-2067, 1985 9) Azuma-Kato M: 99mTc-(SN)-N-pyridoxylaminates:A new series of hepatobiliary imaging agents. J Nucl Med 23:517-524, 1982 4) 安永忠正,広田嘉久,上野助義,他:肝細胞癌およびその転移巣における99mTc-HIDAシンチグラフィーの臨床的意義.柱医学19:523, 1982 |
| References_xml | – reference: 5) Savitch I, Kew MC, Paterson A: Uptake of 99mTc-di-isopropyliminodiacetic acid by hepatocellular carcinoma. Concise communication. J Nucl Med 24:1119, 1983 – reference: 9) Azuma-Kato M: 99mTc-(SN)-N-pyridoxylaminates:A new series of hepatobiliary imaging agents. J Nucl Med 23:517-524, 1982 – reference: 6) 長谷川義尚,中野俊一,野口敦司,他:肝細胞癌の診断における9emTc-(SN)-N-pyridoxy1-5-methyl-tryptophan〔99mTc-PMT〕の臨床的評価.核医学20:1355, 1983 – reference: 7) 柏木徹,東正洋,松田裕之,他:肝細胞癌における99mTc-N-pyridoxy1-5-methyltryptophan肝胆道シンチグラフィーの診断的意義.日消誌82(9):2061-2067, 1985 – reference: 10) 吉田宏,金森勇雄,中野哲,他:99mTc-Npyridoxy1-5-methyltryptophan (99mTc-PMT)による肝・胆道シンチグラフィーの基礎的および臨床的検討.Radioisotopes 32:340-343, 1983 – reference: 11) 中野哲,熊田卓,太田博郷,他:細小肝細胞癌の臨床的研究.肝臓 23:782-791,1982 – reference: 13) Hasegawa Y, Nakano S, Ibuka K: Concentration of 99mTc-(SN)-N-pyridoxy1-5-methyltryptophan, a biliary agent, in distant metastases df hepatomas. Eur J Nucl Med 10: 255-258, 1985 – reference: 4) 安永忠正,広田嘉久,上野助義,他:肝細胞癌およびその転移巣における99mTc-HIDAシンチグラフィーの臨床的意義.柱医学19:523, 1982 – reference: 12)中野哲,熊田 卓:肝癌診断法の進歩一血清ferritinの価値一.肝胆膵 5:1029-1034, 1982 – reference: 1) Victor WL, Michael JO, Dennis FD: Hepatocellular carcinoma:Uptake of 99mTcIDA in primary tumor and metastasis. AJR 143:57-61, 1984 – reference: 2) Shoop JD: Functional hepatoma demonstrated with rose bengal scanning. Amr J Roentgenol lO7:51, 1969 – reference: 3) Utz AJ, Lull RJ, Andersion JH: Hepatoma visualization with 99mTc-pyridoxylidene glutamate-J Nucl Med 21:747, 1980 – reference: 8) Hasegawa Y, N akano S, Ibuka K:The importance of delayed imaging in the study of hepatoma with a new hepatobiliary agent. J Nucl Med 25:1122-1126, 1984 |
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| Title | The usefulness of 99mTc-PMT hepatobiliary scintigraphy for the diagnosis of hepatic tumor lesions |
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