Vitamin D3 attenuates cognitive deficits and neuroinflammatory responses in ICV-STZ induced sporadic Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by intracellular neurofibrillary tangles and extracellular Aβ deposition. Growing experimental evidence indicate diverse biological effects of vitamin D 3 including antioxidant, neuroprotective, anti-inflammatory and...
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| Published in | Inflammopharmacology Vol. 26; no. 1; pp. 39 - 55 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.02.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by intracellular neurofibrillary tangles and extracellular Aβ deposition. Growing experimental evidence indicate diverse biological effects of vitamin D
3
including antioxidant, neuroprotective, anti-inflammatory and cardiovascular benefits. However, the underlying neuroprotective mechanism of vitamin D
3
is still largely elusive. Therefore, the present study was aimed to investigate the neuroprotective effects of vitamin D
3
on ICV-STZ induced sporadic AD. Our study demonstrated that vitamin D3 pretreatment significantly improved spatial learning and memory functions and effectively mitigated ICV-STZ mediated neuronal oxidative stress, mitochondrial aberrations and improved cholinergic functions. Moreover, vitamin D
3
attenuated hippocampal neuroinflammatory response and reduced neuronal death in cortex and hippocampus. Our findings indicated that prophylactic vitamin D
3
supplementation ameliorated ICV-STZ mediated neurobehavioral alterations, oxidative stress and neuroinflammation thereby improving cholinergic functions and reversed degenerative changes in brain. Thus, our study further provides evidence for its therapeutic supplementation for various neurodegenerative disorders including AD.
Graphical Abstract |
|---|---|
| AbstractList | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by intracellular neurofibrillary tangles and extracellular Aβ deposition. Growing experimental evidence indicate diverse biological effects of vitamin D
3
including antioxidant, neuroprotective, anti-inflammatory and cardiovascular benefits. However, the underlying neuroprotective mechanism of vitamin D
3
is still largely elusive. Therefore, the present study was aimed to investigate the neuroprotective effects of vitamin D
3
on ICV-STZ induced sporadic AD. Our study demonstrated that vitamin D3 pretreatment significantly improved spatial learning and memory functions and effectively mitigated ICV-STZ mediated neuronal oxidative stress, mitochondrial aberrations and improved cholinergic functions. Moreover, vitamin D
3
attenuated hippocampal neuroinflammatory response and reduced neuronal death in cortex and hippocampus. Our findings indicated that prophylactic vitamin D
3
supplementation ameliorated ICV-STZ mediated neurobehavioral alterations, oxidative stress and neuroinflammation thereby improving cholinergic functions and reversed degenerative changes in brain. Thus, our study further provides evidence for its therapeutic supplementation for various neurodegenerative disorders including AD.
Graphical Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by intracellular neurofibrillary tangles and extracellular Aβ deposition. Growing experimental evidence indicate diverse biological effects of vitamin D3 including antioxidant, neuroprotective, anti-inflammatory and cardiovascular benefits. However, the underlying neuroprotective mechanism of vitamin D3 is still largely elusive. Therefore, the present study was aimed to investigate the neuroprotective effects of vitamin D3 on ICV-STZ induced sporadic AD. Our study demonstrated that vitamin D3 pretreatment significantly improved spatial learning and memory functions and effectively mitigated ICV-STZ mediated neuronal oxidative stress, mitochondrial aberrations and improved cholinergic functions. Moreover, vitamin D3 attenuated hippocampal neuroinflammatory response and reduced neuronal death in cortex and hippocampus. Our findings indicated that prophylactic vitamin D3 supplementation ameliorated ICV-STZ mediated neurobehavioral alterations, oxidative stress and neuroinflammation thereby improving cholinergic functions and reversed degenerative changes in brain. Thus, our study further provides evidence for its therapeutic supplementation for various neurodegenerative disorders including AD. |
| Author | Chopra, Kanwaljit Ray, R. S. Yamini, P. |
| Author_xml | – sequence: 1 givenname: P. surname: Yamini fullname: Yamini, P. organization: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences (UIPS), UGC Centre of Advanced Study, Panjab University – sequence: 2 givenname: R. S. surname: Ray fullname: Ray, R. S. organization: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences (UIPS), UGC Centre of Advanced Study, Panjab University – sequence: 3 givenname: Kanwaljit surname: Chopra fullname: Chopra, Kanwaljit email: dr_chopra_k@yahoo.com organization: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences (UIPS), UGC Centre of Advanced Study, Panjab University |
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| Cites_doi | 10.1016/S0197-4580(00)00124-X 10.1016/j.pbb.2013.11.035 10.2174/187152711794653751 10.1073/pnas.1404477111 10.1089/ars.2006.8.1971 10.1002/cne.903510204 10.2174/1567205011310040006 10.1016/0022-1759(83)90303-4 10.1016/j.expneurol.2003.08.015 10.1016/j.pbb.2012.01.004 10.1016/0003-2697(82)90118-X 10.1016/j.mito.2010.05.014 10.1016/j.jnutbio.2010.03.010 10.1101/cshperspect.a006346 10.1016/j.niox.2014.08.009 10.2174/1567205012666150710112618 10.1016/j.ajme.2014.05.005 10.1016/j.pbb.2010.06.010 10.1016/S0024-3205(00)01005-5 10.1186/2045-8118-8-20 10.1016/j.neurobiolaging.2008.10.012 10.1016/j.pbb.2010.01.008 10.1016/j.bbr.2005.02.015 10.1038/nature05292 10.1016/j.neurobiolaging.2013.07.029 10.1155/2012/428010 10.1016/j.neuroscience.2012.02.046 10.1007/978-3-211-98811-4_32 10.1016/0076-6879(67)10055-4 10.1111/j.1471-4159.2005.03637.x 10.1016/j.ejphar.2011.03.026 10.1016/j.lfs.2004.10.036 10.1016/j.brainres.2011.02.072 10.1016/j.neuropharm.2013.07.004 10.1186/1742-2094-9-244 10.1016/j.jff.2015.08.024 10.1159/000136485 10.1016/j.neuroscience.2013.12.064 10.1007/s11064-016-2000-3 10.1038/nrn1588 10.1016/0003-9861(78)90479-4 10.1016/S0891-5849(96)00629-6 10.1016/j.mam.2008.05.001 10.1046/j.1471-4159.1999.0731127.x 10.1016/j.bbr.2015.03.050 10.1371/journal.pone.0046196 10.1016/j.ijdevneu.2015.11.005 10.1016/j.neuroscience.2016.01.041 10.1186/s12937-015-0063-7 10.1083/jcb.32.2.415 10.1016/0006-2952(61)90145-9 10.1017/S0007114515003256 10.1146/annurev.psych.48.1.649 10.1016/j.pbb.2009.05.009 10.1523/JNEUROSCI.2711-13.2014 10.1016/S0169-328X(96)00260-4 10.1016/j.jinorgbio.2005.06.015 10.1016/S0006-8993(98)00759-8 10.1016/j.nbd.2015.06.020 10.1016/0165-0270(80)90021-7 10.1042/bj0990667 10.3233/JAD-140411 10.1111/psyg.12218 10.3233/JAD-2011-101986 10.1016/S0021-9258(18)57021-6 10.3389/fnagi.2010.00012 10.1007/BF03402177 |
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| Keywords | Neuroprotection Neuroinflammation Acetylcholine Alzheimer’s disease Vitamin D Memory |
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| References | Garcion, Nataf, Berod, Darcy, Brachet (CR22) 1997; 45 Bobinski, de Leon, Tarnawski, Wegiel, Reisberg, Miller, Wisniewski (CR8) 1998; 805 Javed (CR28) 2012; 210 Yu, Gattoni-Celli, Zhu, Bhat, Sambamurti, Gattoni-Celli, Kindy (CR69) 2011; 25 Everitt, Robbins (CR19) 1997; 48 Akiyama (CR1) 2000; 21 Buchhave, Zetterberg, Blennow, Minthon, Janciauskiene, Hansson (CR11) 2010; 31 Claiborne, GreenWald (CR14) 1985 Shen, Ji (CR60) 2015; 14 Labak, Foniok, Kirk, Rushforth, Tomanek, Jasiński, Grieb (CR39) 2010; 106 Sonkusare, Srinivasan, Kaul, Ramarao (CR62) 2005; 77 Nissou, Guttin, Zenga, Berger, Issartel, Wion (CR47) 2014; 42 Guo, He, Zhang, Wang, Liu, Peng (CR25) 2016; 322 Misra, Tiwari, Kuhad, Chopra (CR44) 2011; 659 Paidi, Nthenge-Ngumbau, Singh, Kankanala, Mehta, Mohanakumar (CR48) 2015; 12 Wang, Michaelis (CR65) 2010; 2 Kaizer, Correa, Spanevello, Morsch, Mazzanti, Goncalves, Schetinger (CR31) 2005; 99 Wills (CR66) 1966; 99 Butterfield (CR13) 2006; 8 Peeyush, Savitha, Sherin, Anju, Jes, Paulose (CR51) 2010; 95 Jiang (CR29) 2015; 114 Gornall, Bardawill, David (CR23) 1949; 177 Sharma, Gupta (CR57) 2001; 68 Green, Wagner, Glogowski, Skipper, Wishnok, Tannenbaum (CR24) 1982; 126 King, Howard (CR34) 1967; 10 Sarter, Parikh (CR56) 2005; 6 Kumar, Antony, Nandhu, Sadanandan, Naijil, Paulose (CR37) 2011; 22 Ray, Rai, Katyal (CR53) 2014; 43 Frankola, Greig, Luo, Tweedie (CR20) 2011; 10 Sachdeva, Chopra (CR54) 2015; 19 Wyss-Coray, Rogers (CR68) 2012; 2 Kono (CR35) 1978; 186 Alrefaie, Alhayani (CR2) 2015; 287 Kuzmenko, Morozova, Nikolenko, Korniets, Kholodova (CR38) 1997; 62 Ellman, Courtney, Andres, Featherstone (CR18) 1961; 7 Markesbery (CR43) 1997; 23 Jollow, Mitchell, Na, Gillette (CR30) 1974; 11 Kraska (CR36) 2012; 7 Latimer (CR40) 2014; 111 Lin, Beal (CR41) 2006; 443 Rai, Kamat, Nath, Shukla (CR52) 2014; 117 Sharma, Bala, Deshmukh, Bedi, Sharma (CR59) 2012; 101 Shoham, Bejar, Kovalev, Weinstock (CR61) 2003; 184 Annweiler, Brugg, Peyrin, Bartha, Beauchet (CR4) 2014; 35 Berman, Hastings (CR7) 1999; 73 Dulla, Kurauchi, Hisatsune, Seki, Shudo, Katsuki (CR16) 2016; 41 Salkovic-Petrisic, Tribl, Schmidt, Hoyer, Riederer (CR55) 2006; 96 Correia (CR15) 2013; 10 Mohamed, Soliman, Ismail, Mannaa (CR45) 2015; 51 Briones, Darwish (CR10) 2014; 262 Tiwari, Kuhad, Bishnoi, Chopra (CR64) 2009; 93 Kim, Lee, Kim (CR33) 2017 Buell, Dawson-Hughes (CR12) 2008; 29 Gandhi, Abramov (CR21) 2012; 2012 Sharma, Deshmukh, Bedi (CR58) 2010; 96 Durk, Han, Chow, Ahrens, Henderson, Fraser, Pang (CR17) 2014; 34 Becker, Eyles, McGrath, Grecksch (CR6) 2005; 161 Anand, Gill, Mahdi (CR3) 2014; 76 Arendt, Bruckner, Bigl, Marcova (CR5) 1995; 351 Pavlov, Wang, Czura, Friedman, Tracey (CR49) 2003; 9 Paxinos, Watson, Emson (CR50) 1980; 3 Ito, Ohtsuki, Nezu, Koitabashi, Murata, Terasaki (CR26) 2011; 8 Briones, Darwish (CR9) 2012; 9 Sottocasa, Kuylenstierna, Ernster, Bergstrand (CR63) 1967; 32 Keeney, Butterfield (CR32) 2015; 84 Witte, Geurts, de Vries, van der Valk, van Horssen (CR67) 2010; 10 Javed (CR27) 2011; 1389 Longoni (CR42) 2016; 48 Mosmann (CR46) 1983; 65 H Javed (372_CR27) 2011; 1389 KT Peeyush (372_CR51) 2010; 95 S Rai (372_CR52) 2014; 117 E Wills (372_CR66) 1966; 99 PT Kumar (372_CR37) 2011; 22 S Misra (372_CR44) 2011; 659 GL Sottocasa (372_CR63) 1967; 32 YX Guo (372_CR25) 2016; 322 GL Ellman (372_CR18) 1961; 7 M Salkovic-Petrisic (372_CR55) 2006; 96 T Mosmann (372_CR46) 1983; 65 MF Nissou (372_CR47) 2014; 42 YA Dulla (372_CR16) 2016; 41 R Anand (372_CR3) 2014; 76 E Garcion (372_CR22) 1997; 45 Y Kono (372_CR35) 1978; 186 P Buchhave (372_CR11) 2010; 31 V Sharma (372_CR59) 2012; 101 VA Pavlov (372_CR49) 2003; 9 S Shoham (372_CR61) 2003; 184 MT Lin (372_CR41) 2006; 443 CS Latimer (372_CR40) 2014; 111 J Yu (372_CR69) 2011; 25 J Jiang (372_CR29) 2015; 114 D Jollow (372_CR30) 1974; 11 T Wyss-Coray (372_CR68) 2012; 2 M Bobinski (372_CR8) 1998; 805 Z Alrefaie (372_CR2) 2015; 287 S Ito (372_CR26) 2011; 8 M Labak (372_CR39) 2010; 106 AK Sachdeva (372_CR54) 2015; 19 AR Mohamed (372_CR45) 2015; 51 RS Ray (372_CR53) 2014; 43 A Claiborne (372_CR14) 1985 S Sonkusare (372_CR62) 2005; 77 V Tiwari (372_CR64) 2009; 93 JT Keeney (372_CR32) 2015; 84 M Sarter (372_CR56) 2005; 6 DA Butterfield (372_CR13) 2006; 8 MR Durk (372_CR17) 2014; 34 SC Correia (372_CR15) 2013; 10 JS Buell (372_CR12) 2008; 29 TL Briones (372_CR9) 2012; 9 AG Gornall (372_CR23) 1949; 177 LC Green (372_CR24) 1982; 126 C Annweiler (372_CR4) 2014; 35 M Sharma (372_CR57) 2001; 68 G Paxinos (372_CR50) 1980; 3 X Wang (372_CR65) 2010; 2 A Becker (372_CR6) 2005; 161 L Shen (372_CR60) 2015; 14 RR Kaizer (372_CR31) 2005; 99 A Kraska (372_CR36) 2012; 7 SB Berman (372_CR7) 1999; 73 KA Frankola (372_CR20) 2011; 10 RK Paidi (372_CR48) 2015; 12 ME Witte (372_CR67) 2010; 10 BJ Everitt (372_CR19) 1997; 48 H Javed (372_CR28) 2012; 210 YS Kim (372_CR33) 2017 TL Briones (372_CR10) 2014; 262 A Longoni (372_CR42) 2016; 48 S Gandhi (372_CR21) 2012; 2012 T Arendt (372_CR5) 1995; 351 AI Kuzmenko (372_CR38) 1997; 62 WR Markesbery (372_CR43) 1997; 23 TE King (372_CR34) 1967; 10 H Akiyama (372_CR1) 2000; 21 N Sharma (372_CR58) 2010; 96 |
| References_xml | – volume: 21 start-page: 383 year: 2000 end-page: 421 ident: CR1 article-title: Inflammation and Alzheimer’s disease publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(00)00124-X contributor: fullname: Akiyama – volume: 117 start-page: 104 year: 2014 end-page: 117 ident: CR52 article-title: Glial activation and post-synaptic neurotoxicity: the key events in streptozotocin (ICV) induced memory impairment in rats publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2013.11.035 contributor: fullname: Shukla – volume: 10 start-page: 391 year: 2011 end-page: 403 ident: CR20 article-title: Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases publication-title: CNS Neurol Disord Drug Targets doi: 10.2174/187152711794653751 contributor: fullname: Tweedie – volume: 111 start-page: E4359 year: 2014 end-page: E4366 ident: CR40 article-title: Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1404477111 contributor: fullname: Latimer – volume: 8 start-page: 1971 year: 2006 end-page: 1973 ident: CR13 article-title: Oxidative stress in neurodegenerative disorders publication-title: Antioxid Redox Signal doi: 10.1089/ars.2006.8.1971 contributor: fullname: Butterfield – volume: 351 start-page: 223 year: 1995 end-page: 246 ident: CR5 article-title: Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer’s disease. III. The basal forebrain compared with other subcortical areas publication-title: J Comp Neurol doi: 10.1002/cne.903510204 contributor: fullname: Marcova – volume: 10 start-page: 406 year: 2013 end-page: 419 ident: CR15 article-title: Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer’s disease publication-title: Curr Alzheimer Res doi: 10.2174/1567205011310040006 contributor: fullname: Correia – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: CR46 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J Immunol Methods doi: 10.1016/0022-1759(83)90303-4 contributor: fullname: Mosmann – volume: 184 start-page: 1043 year: 2003 end-page: 1052 ident: CR61 article-title: Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats publication-title: Exp Neurol doi: 10.1016/j.expneurol.2003.08.015 contributor: fullname: Weinstock – volume: 101 start-page: 239 year: 2012 end-page: 245 ident: CR59 article-title: Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2012.01.004 contributor: fullname: Sharma – volume: 126 start-page: 131 year: 1982 end-page: 138 ident: CR24 article-title: Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids publication-title: Anal Biochem doi: 10.1016/0003-2697(82)90118-X contributor: fullname: Tannenbaum – volume: 10 start-page: 411 year: 2010 end-page: 418 ident: CR67 article-title: Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? publication-title: Mitochondrion doi: 10.1016/j.mito.2010.05.014 contributor: fullname: van Horssen – volume: 177 start-page: 751 year: 1949 end-page: 766 ident: CR23 article-title: Determination of serum proteins by means of the biuret reaction publication-title: J Biol Chem contributor: fullname: David – volume: 62 start-page: 609 year: 1997 end-page: 612 ident: CR38 article-title: Effects of vitamin D3 and ecdysterone on free-radical lipid peroxidation publication-title: Biochem Biokhimiia contributor: fullname: Kholodova – volume: 22 start-page: 418 year: 2011 end-page: 425 ident: CR37 article-title: Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2010.03.010 contributor: fullname: Paulose – volume: 2 start-page: a006346 year: 2012 ident: CR68 article-title: Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006346 contributor: fullname: Rogers – volume: 2 start-page: 12 year: 2010 ident: CR65 article-title: Selective neuronal vulnerability to oxidative stress in the brain publication-title: Front Aging Neurosci contributor: fullname: Michaelis – volume: 43 start-page: 62 year: 2014 end-page: 73 ident: CR53 article-title: Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice publication-title: Nitric Oxide doi: 10.1016/j.niox.2014.08.009 contributor: fullname: Katyal – volume: 12 start-page: 785 year: 2015 end-page: 795 ident: CR48 article-title: Mitochondrial deficits accompany cognitive decline following single bilateral intracerebroventricular streptozotocin publication-title: Curr Alzheimer Res doi: 10.2174/1567205012666150710112618 contributor: fullname: Mohanakumar – year: 2017 ident: CR33 article-title: Serum tumour necrosis factor-alpha and interleukin-6 levels in Alzheimer’s disease and mild cognitive impairment publication-title: Psychogeriatrics contributor: fullname: Kim – volume: 25 start-page: 295 year: 2011 end-page: 307 ident: CR69 article-title: Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AbetaPP transgenic mice publication-title: J Alzheimer’s Dis contributor: fullname: Kindy – volume: 51 start-page: 127 year: 2015 end-page: 136 ident: CR45 article-title: Neuroprotective role of vitamin D3 in colchicine-induced Alzheimer’s disease in rats publication-title: Alex J Med doi: 10.1016/j.ajme.2014.05.005 contributor: fullname: Mannaa – volume: 96 start-page: 386 year: 2010 end-page: 394 ident: CR58 article-title: SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2010.06.010 contributor: fullname: Bedi – volume: 68 start-page: 1021 year: 2001 end-page: 1029 ident: CR57 article-title: Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment publication-title: Life Sci doi: 10.1016/S0024-3205(00)01005-5 contributor: fullname: Gupta – volume: 8 start-page: 20 year: 2011 ident: CR26 article-title: 1alpha,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-beta peptide(1-40) from mouse brain across the blood-brain barrier publication-title: Fluids Barriers CNS doi: 10.1186/2045-8118-8-20 contributor: fullname: Terasaki – volume: 31 start-page: 1877 year: 2010 end-page: 1884 ident: CR11 article-title: Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.10.012 contributor: fullname: Hansson – volume: 95 start-page: 216 year: 2010 end-page: 222 ident: CR51 article-title: Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: functional regulation with vitamin D3 supplementation publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2010.01.008 contributor: fullname: Paulose – volume: 161 start-page: 306 year: 2005 end-page: 312 ident: CR6 article-title: Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats publication-title: Behav Brain Res doi: 10.1016/j.bbr.2005.02.015 contributor: fullname: Grecksch – volume: 443 start-page: 787 year: 2006 end-page: 795 ident: CR41 article-title: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases publication-title: Nature doi: 10.1038/nature05292 contributor: fullname: Beal – volume: 35 start-page: 331 year: 2014 end-page: 335 ident: CR4 article-title: Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2013.07.029 contributor: fullname: Beauchet – volume: 2012 start-page: 428010 year: 2012 ident: CR21 article-title: Mechanism of oxidative stress in neurodegeneration publication-title: Oxidative Med Cell Longev doi: 10.1155/2012/428010 contributor: fullname: Abramov – volume: 210 start-page: 340 year: 2012 end-page: 352 ident: CR28 article-title: Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.02.046 contributor: fullname: Javed – volume: 106 start-page: 177 year: 2010 end-page: 181 ident: CR39 article-title: Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer’s disease publication-title: Acta Neurochir Suppl doi: 10.1007/978-3-211-98811-4_32 contributor: fullname: Grieb – volume: 10 start-page: 275 year: 1967 end-page: 294 ident: CR34 article-title: [52] Preparations and properties of soluble NADH dehydrogenases from cardiac muscle publication-title: Methods Enzymol doi: 10.1016/0076-6879(67)10055-4 contributor: fullname: Howard – volume: 96 start-page: 1005 year: 2006 end-page: 1015 ident: CR55 article-title: Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03637.x contributor: fullname: Riederer – volume: 659 start-page: 177 year: 2011 end-page: 186 ident: CR44 article-title: Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2011.03.026 contributor: fullname: Chopra – volume: 77 start-page: 1 year: 2005 end-page: 14 ident: CR62 article-title: Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats publication-title: Life Sci doi: 10.1016/j.lfs.2004.10.036 contributor: fullname: Ramarao – volume: 1389 start-page: 133 year: 2011 end-page: 142 ident: CR27 article-title: S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer’s type publication-title: Brain Res doi: 10.1016/j.brainres.2011.02.072 contributor: fullname: Javed – volume: 76 start-page: 27 year: 2014 end-page: 50 ident: CR3 article-title: Therapeutics of Alzheimer’s disease: past, present and future publication-title: Neuropharmacol doi: 10.1016/j.neuropharm.2013.07.004 contributor: fullname: Mahdi – volume: 9 start-page: 244 year: 2012 ident: CR9 article-title: Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden publication-title: J Neuroinflamm doi: 10.1186/1742-2094-9-244 contributor: fullname: Darwish – volume: 19 start-page: 110 year: 2015 end-page: 125 ident: CR54 article-title: Naringin mitigate okadaic acid-induced cognitive impairment in an experimental paradigm of Alzheimer’s disease publication-title: J Funct Foods doi: 10.1016/j.jff.2015.08.024 contributor: fullname: Chopra – volume: 11 start-page: 151 year: 1974 end-page: 169 ident: CR30 article-title: Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite publication-title: Pharmacology doi: 10.1159/000136485 contributor: fullname: Gillette – volume: 9 start-page: 125 year: 2003 end-page: 134 ident: CR49 article-title: The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation publication-title: Mol Med contributor: fullname: Tracey – volume: 262 start-page: 143 year: 2014 end-page: 155 ident: CR10 article-title: Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state publication-title: Neuroscience doi: 10.1016/j.neuroscience.2013.12.064 contributor: fullname: Darwish – volume: 41 start-page: 2848 issue: 11 year: 2016 end-page: 2858 ident: CR16 article-title: Regulatory mechanisms of vitamin D3 on production of nitric oxide and pro-inflammatory cytokines in microglial BV-2 cells neurochemical research publication-title: Neurochem Res doi: 10.1007/s11064-016-2000-3 contributor: fullname: Katsuki – volume: 6 start-page: 48 year: 2005 end-page: 56 ident: CR56 article-title: Choline transporters, cholinergic transmission and cognition publication-title: Nat Rev Neurosci doi: 10.1038/nrn1588 contributor: fullname: Parikh – volume: 186 start-page: 189 year: 1978 end-page: 195 ident: CR35 article-title: Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase publication-title: Arch Biochem Biophys doi: 10.1016/0003-9861(78)90479-4 contributor: fullname: Kono – volume: 23 start-page: 134 year: 1997 end-page: 147 ident: CR43 article-title: Oxidative stress hypothesis in Alzheimer’s disease publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(96)00629-6 contributor: fullname: Markesbery – volume: 29 start-page: 415 year: 2008 end-page: 422 ident: CR12 article-title: Vitamin D and neurocognitive dysfunction: preventing “D”ecline? publication-title: Mol Aspects Med doi: 10.1016/j.mam.2008.05.001 contributor: fullname: Dawson-Hughes – volume: 73 start-page: 1127 year: 1999 end-page: 1137 ident: CR7 article-title: Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria publication-title: J Neurochem doi: 10.1046/j.1471-4159.1999.0731127.x contributor: fullname: Hastings – volume: 287 start-page: 156 year: 2015 end-page: 162 ident: CR2 article-title: vitamin D(3) improves decline in cognitive function and cholinergic transmission in prefrontal cortex of streptozotocin-induced diabetic rats publication-title: Behav Brain Res doi: 10.1016/j.bbr.2015.03.050 contributor: fullname: Alhayani – volume: 7 start-page: e46196 year: 2012 ident: CR36 article-title: In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin publication-title: PloS ONE doi: 10.1371/journal.pone.0046196 contributor: fullname: Kraska – volume: 48 start-page: 71 year: 2016 end-page: 79 ident: CR42 article-title: 1,25-Dihydroxyvitamin D3 exerts neuroprotective effects in an ex vivo model of mild hyperhomocysteinemia publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2015.11.005 contributor: fullname: Longoni – volume: 322 start-page: 28 year: 2016 end-page: 38 ident: CR25 article-title: 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Abeta1-40 brain-to-blood efflux and peripheral uptake transport publication-title: Neuroscience doi: 10.1016/j.neuroscience.2016.01.041 contributor: fullname: Peng – volume: 14 start-page: 76 year: 2015 ident: CR60 article-title: Vitamin D deficiency is associated with increased risk of Alzheimer’s disease and dementia: evidence from meta-analysis publication-title: Nutr J doi: 10.1186/s12937-015-0063-7 contributor: fullname: Ji – volume: 32 start-page: 415 year: 1967 end-page: 438 ident: CR63 article-title: An electron-transport system associated with the outer membrane of liver mitochondria a biochemical and morphological study publication-title: J Cell Biol doi: 10.1083/jcb.32.2.415 contributor: fullname: Bergstrand – volume: 7 start-page: 88 year: 1961 end-page: 95 ident: CR18 article-title: A new and rapid colorimetric determination of acetylcholinesterase activity publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(61)90145-9 contributor: fullname: Featherstone – volume: 114 start-page: 1560 year: 2015 end-page: 1568 ident: CR29 article-title: Vitamin D inhibits lipopolysaccharide-induced inflammatory response potentially through the toll-like receptor 4 signalling pathway in the intestine and enterocytes of juvenile Jian carp ( var. Jian) publication-title: Br J Nutr doi: 10.1017/S0007114515003256 contributor: fullname: Jiang – volume: 48 start-page: 649 year: 1997 end-page: 684 ident: CR19 article-title: Central cholinergic systems and cognition publication-title: Annu Rev Psychol doi: 10.1146/annurev.psych.48.1.649 contributor: fullname: Robbins – volume: 93 start-page: 183 year: 2009 end-page: 189 ident: CR64 article-title: Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2009.05.009 contributor: fullname: Chopra – volume: 34 start-page: 7091 year: 2014 end-page: 7101 ident: CR17 article-title: 1alpha,25-Dihydroxyvitamin D3 reduces cerebral amyloid-beta accumulation and improves cognition in mouse models of Alzheimer’s disease publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2711-13.2014 contributor: fullname: Pang – volume: 45 start-page: 255 year: 1997 end-page: 267 ident: CR22 article-title: 1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis Brain research publication-title: Mol Brain Res doi: 10.1016/S0169-328X(96)00260-4 contributor: fullname: Brachet – volume: 99 start-page: 1865 year: 2005 end-page: 1870 ident: CR31 article-title: Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions publication-title: J Inorg Biochem doi: 10.1016/j.jinorgbio.2005.06.015 contributor: fullname: Schetinger – volume: 805 start-page: 267 year: 1998 end-page: 269 ident: CR8 article-title: Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease publication-title: Brain Res doi: 10.1016/S0006-8993(98)00759-8 contributor: fullname: Wisniewski – volume: 84 start-page: 84 year: 2015 end-page: 98 ident: CR32 article-title: Vitamin D deficiency and Alzheimer disease: common links publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2015.06.020 contributor: fullname: Butterfield – volume: 42 start-page: 789 year: 2014 end-page: 799 ident: CR47 article-title: Additional clues for a protective role of vitamin D in neurodegenerative diseases: 1,25-dihydroxyvitamin D3 triggers an anti-inflammatory response in brain pericytes publication-title: J Alzheimer’s Dis contributor: fullname: Wion – start-page: 283 year: 1985 end-page: 284 ident: CR14 article-title: Catalase activity publication-title: CRC handbook of methods for oxygen radical research contributor: fullname: GreenWald – volume: 3 start-page: 129 year: 1980 end-page: 149 ident: CR50 article-title: AChE-stained horizontal sections of the rat brain in stereotaxic coordinates publication-title: J Neurosci Methods doi: 10.1016/0165-0270(80)90021-7 contributor: fullname: Emson – volume: 99 start-page: 667 year: 1966 ident: CR66 article-title: Mechanisms of lipid peroxide formation in animal tissues publication-title: Biochem J doi: 10.1042/bj0990667 contributor: fullname: Wills – volume: 42 start-page: 789 year: 2014 ident: 372_CR47 publication-title: J Alzheimer’s Dis doi: 10.3233/JAD-140411 contributor: fullname: MF Nissou – volume: 93 start-page: 183 year: 2009 ident: 372_CR64 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2009.05.009 contributor: fullname: V Tiwari – volume: 99 start-page: 667 year: 1966 ident: 372_CR66 publication-title: Biochem J doi: 10.1042/bj0990667 contributor: fullname: E Wills – volume: 73 start-page: 1127 year: 1999 ident: 372_CR7 publication-title: J Neurochem doi: 10.1046/j.1471-4159.1999.0731127.x contributor: fullname: SB Berman – volume: 99 start-page: 1865 year: 2005 ident: 372_CR31 publication-title: J Inorg Biochem doi: 10.1016/j.jinorgbio.2005.06.015 contributor: fullname: RR Kaizer – volume: 95 start-page: 216 year: 2010 ident: 372_CR51 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2010.01.008 contributor: fullname: KT Peeyush – volume: 10 start-page: 406 year: 2013 ident: 372_CR15 publication-title: Curr Alzheimer Res doi: 10.2174/1567205011310040006 contributor: fullname: SC Correia – volume: 7 start-page: 88 year: 1961 ident: 372_CR18 publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(61)90145-9 contributor: fullname: GL Ellman – volume: 805 start-page: 267 year: 1998 ident: 372_CR8 publication-title: Brain Res doi: 10.1016/S0006-8993(98)00759-8 contributor: fullname: M Bobinski – volume: 19 start-page: 110 year: 2015 ident: 372_CR54 publication-title: J Funct Foods doi: 10.1016/j.jff.2015.08.024 contributor: fullname: AK Sachdeva – volume: 1389 start-page: 133 year: 2011 ident: 372_CR27 publication-title: Brain Res doi: 10.1016/j.brainres.2011.02.072 contributor: fullname: H Javed – year: 2017 ident: 372_CR33 publication-title: Psychogeriatrics doi: 10.1111/psyg.12218 contributor: fullname: YS Kim – volume: 77 start-page: 1 year: 2005 ident: 372_CR62 publication-title: Life Sci doi: 10.1016/j.lfs.2004.10.036 contributor: fullname: S Sonkusare – volume: 62 start-page: 609 year: 1997 ident: 372_CR38 publication-title: Biochem Biokhimiia contributor: fullname: AI Kuzmenko – volume: 96 start-page: 1005 year: 2006 ident: 372_CR55 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03637.x contributor: fullname: M Salkovic-Petrisic – volume: 21 start-page: 383 year: 2000 ident: 372_CR1 publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(00)00124-X contributor: fullname: H Akiyama – volume: 11 start-page: 151 year: 1974 ident: 372_CR30 publication-title: Pharmacology doi: 10.1159/000136485 contributor: fullname: D Jollow – volume: 76 start-page: 27 year: 2014 ident: 372_CR3 publication-title: Neuropharmacol doi: 10.1016/j.neuropharm.2013.07.004 contributor: fullname: R Anand – volume: 31 start-page: 1877 year: 2010 ident: 372_CR11 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.10.012 contributor: fullname: P Buchhave – volume: 25 start-page: 295 year: 2011 ident: 372_CR69 publication-title: J Alzheimer’s Dis doi: 10.3233/JAD-2011-101986 contributor: fullname: J Yu – volume: 10 start-page: 391 year: 2011 ident: 372_CR20 publication-title: CNS Neurol Disord Drug Targets doi: 10.2174/187152711794653751 contributor: fullname: KA Frankola – volume: 177 start-page: 751 year: 1949 ident: 372_CR23 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)57021-6 contributor: fullname: AG Gornall – volume: 117 start-page: 104 year: 2014 ident: 372_CR52 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2013.11.035 contributor: fullname: S Rai – volume: 3 start-page: 129 year: 1980 ident: 372_CR50 publication-title: J Neurosci Methods doi: 10.1016/0165-0270(80)90021-7 contributor: fullname: G Paxinos – volume: 2012 start-page: 428010 year: 2012 ident: 372_CR21 publication-title: Oxidative Med Cell Longev doi: 10.1155/2012/428010 contributor: fullname: S Gandhi – volume: 48 start-page: 71 year: 2016 ident: 372_CR42 publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2015.11.005 contributor: fullname: A Longoni – volume: 22 start-page: 418 year: 2011 ident: 372_CR37 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2010.03.010 contributor: fullname: PT Kumar – volume: 96 start-page: 386 year: 2010 ident: 372_CR58 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2010.06.010 contributor: fullname: N Sharma – volume: 186 start-page: 189 year: 1978 ident: 372_CR35 publication-title: Arch Biochem Biophys doi: 10.1016/0003-9861(78)90479-4 contributor: fullname: Y Kono – volume: 2 start-page: a006346 year: 2012 ident: 372_CR68 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006346 contributor: fullname: T Wyss-Coray – volume: 35 start-page: 331 year: 2014 ident: 372_CR4 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2013.07.029 contributor: fullname: C Annweiler – volume: 43 start-page: 62 year: 2014 ident: 372_CR53 publication-title: Nitric Oxide doi: 10.1016/j.niox.2014.08.009 contributor: fullname: RS Ray – volume: 106 start-page: 177 year: 2010 ident: 372_CR39 publication-title: Acta Neurochir Suppl doi: 10.1007/978-3-211-98811-4_32 contributor: fullname: M Labak – volume: 32 start-page: 415 year: 1967 ident: 372_CR63 publication-title: J Cell Biol doi: 10.1083/jcb.32.2.415 contributor: fullname: GL Sottocasa – volume: 126 start-page: 131 year: 1982 ident: 372_CR24 publication-title: Anal Biochem doi: 10.1016/0003-2697(82)90118-X contributor: fullname: LC Green – volume: 161 start-page: 306 year: 2005 ident: 372_CR6 publication-title: Behav Brain Res doi: 10.1016/j.bbr.2005.02.015 contributor: fullname: A Becker – volume: 8 start-page: 1971 year: 2006 ident: 372_CR13 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2006.8.1971 contributor: fullname: DA Butterfield – start-page: 283 volume-title: CRC handbook of methods for oxygen radical research year: 1985 ident: 372_CR14 contributor: fullname: A Claiborne – volume: 287 start-page: 156 year: 2015 ident: 372_CR2 publication-title: Behav Brain Res doi: 10.1016/j.bbr.2015.03.050 contributor: fullname: Z Alrefaie – volume: 12 start-page: 785 year: 2015 ident: 372_CR48 publication-title: Curr Alzheimer Res doi: 10.2174/1567205012666150710112618 contributor: fullname: RK Paidi – volume: 2 start-page: 12 year: 2010 ident: 372_CR65 publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2010.00012 contributor: fullname: X Wang – volume: 48 start-page: 649 year: 1997 ident: 372_CR19 publication-title: Annu Rev Psychol doi: 10.1146/annurev.psych.48.1.649 contributor: fullname: BJ Everitt – volume: 41 start-page: 2848 issue: 11 year: 2016 ident: 372_CR16 publication-title: Neurochem Res doi: 10.1007/s11064-016-2000-3 contributor: fullname: YA Dulla – volume: 114 start-page: 1560 year: 2015 ident: 372_CR29 publication-title: Br J Nutr doi: 10.1017/S0007114515003256 contributor: fullname: J Jiang – volume: 184 start-page: 1043 year: 2003 ident: 372_CR61 publication-title: Exp Neurol doi: 10.1016/j.expneurol.2003.08.015 contributor: fullname: S Shoham – volume: 34 start-page: 7091 year: 2014 ident: 372_CR17 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2711-13.2014 contributor: fullname: MR Durk – volume: 9 start-page: 125 year: 2003 ident: 372_CR49 publication-title: Mol Med doi: 10.1007/BF03402177 contributor: fullname: VA Pavlov – volume: 322 start-page: 28 year: 2016 ident: 372_CR25 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2016.01.041 contributor: fullname: YX Guo – volume: 84 start-page: 84 year: 2015 ident: 372_CR32 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2015.06.020 contributor: fullname: JT Keeney – volume: 351 start-page: 223 year: 1995 ident: 372_CR5 publication-title: J Comp Neurol doi: 10.1002/cne.903510204 contributor: fullname: T Arendt – volume: 111 start-page: E4359 year: 2014 ident: 372_CR40 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1404477111 contributor: fullname: CS Latimer – volume: 6 start-page: 48 year: 2005 ident: 372_CR56 publication-title: Nat Rev Neurosci doi: 10.1038/nrn1588 contributor: fullname: M Sarter – volume: 45 start-page: 255 year: 1997 ident: 372_CR22 publication-title: Mol Brain Res doi: 10.1016/S0169-328X(96)00260-4 contributor: fullname: E Garcion – volume: 14 start-page: 76 year: 2015 ident: 372_CR60 publication-title: Nutr J doi: 10.1186/s12937-015-0063-7 contributor: fullname: L Shen – volume: 210 start-page: 340 year: 2012 ident: 372_CR28 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.02.046 contributor: fullname: H Javed – volume: 7 start-page: e46196 year: 2012 ident: 372_CR36 publication-title: PloS ONE doi: 10.1371/journal.pone.0046196 contributor: fullname: A Kraska – volume: 8 start-page: 20 year: 2011 ident: 372_CR26 publication-title: Fluids Barriers CNS doi: 10.1186/2045-8118-8-20 contributor: fullname: S Ito – volume: 51 start-page: 127 year: 2015 ident: 372_CR45 publication-title: Alex J Med doi: 10.1016/j.ajme.2014.05.005 contributor: fullname: AR Mohamed – volume: 10 start-page: 275 year: 1967 ident: 372_CR34 publication-title: Methods Enzymol doi: 10.1016/0076-6879(67)10055-4 contributor: fullname: TE King – volume: 262 start-page: 143 year: 2014 ident: 372_CR10 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2013.12.064 contributor: fullname: TL Briones – volume: 9 start-page: 244 year: 2012 ident: 372_CR9 publication-title: J Neuroinflamm doi: 10.1186/1742-2094-9-244 contributor: fullname: TL Briones – volume: 659 start-page: 177 year: 2011 ident: 372_CR44 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2011.03.026 contributor: fullname: S Misra – volume: 10 start-page: 411 year: 2010 ident: 372_CR67 publication-title: Mitochondrion doi: 10.1016/j.mito.2010.05.014 contributor: fullname: ME Witte – volume: 65 start-page: 55 year: 1983 ident: 372_CR46 publication-title: J Immunol Methods doi: 10.1016/0022-1759(83)90303-4 contributor: fullname: T Mosmann – volume: 29 start-page: 415 year: 2008 ident: 372_CR12 publication-title: Mol Aspects Med doi: 10.1016/j.mam.2008.05.001 contributor: fullname: JS Buell – volume: 68 start-page: 1021 year: 2001 ident: 372_CR57 publication-title: Life Sci doi: 10.1016/S0024-3205(00)01005-5 contributor: fullname: M Sharma – volume: 101 start-page: 239 year: 2012 ident: 372_CR59 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2012.01.004 contributor: fullname: V Sharma – volume: 443 start-page: 787 year: 2006 ident: 372_CR41 publication-title: Nature doi: 10.1038/nature05292 contributor: fullname: MT Lin – volume: 23 start-page: 134 year: 1997 ident: 372_CR43 publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(96)00629-6 contributor: fullname: WR Markesbery |
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| Title | Vitamin D3 attenuates cognitive deficits and neuroinflammatory responses in ICV-STZ induced sporadic Alzheimer’s disease |
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