Continuous flow synthesis and separation of mandelic acid enantiomers in a modular microfluidic system

• Published in: Separation and purification technology Vol. 309; p. 123009
• Main Authors: Kralik, Dominik, Kovářová, Anna, Vobecká, Lucie, Hasal, Pavel, Slouka, Zdeněk, Přibyl, Michal
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.03.2023
• Subjects: Continuous flow process; Electroseparator; Enantiomers; Mandelic acid; Membrane microseparator; Packed-bed reactor; Mandelic acid; Packed-bed reactor; Membrane microseparator; Enantiomers; Electroseparator; Continuous flow process

•Mandelic acid enantiomers are produced in a modular microreactor-microseparator.•Modular system operates in a fully continuous flow regime.•Immobilized lipase preferentially synthesizes (R)-(−)-mandelic acid within minutes.•Enantiomers are separated in a membrane module with inserted dialysis membr...