The Downregulation of ITGAX Exacerbates Amyloid-β Plaque Deposition in Alzheimer's Disease by Increasing Polarization of M1 Microglia

• Published in: Journal of Alzheimer's disease Vol. 100; no. 2; p. 657
• Main Authors: Hu, Yufei, Wang, Xupeng, Zhao, Zijun, Liu, Menglin, Ren, Xiaoqin, Xian, Xiaohui, Liu, Chunxiao, Wang, Qiujun
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; Disease Models, Animal; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia - metabolism; Microglia - pathology; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Presenilin-1 - genetics; neurodegeneration; scRNA-seq; M1 microglia; Alzheimer’s disease

Alzheimer's disease (AD) is the most common sort of neurodegenerative dementia, characterized by its challenging, diverse, and progressive nature. Despite significant progress in neuroscience, the current treatment strategies remain suboptimal. Identifying a more accurate molecular target for t...