Safety assessment of yerba mate (Ilex paraguariensis) dried extract: Results of acute and 90days subchronic toxicity studies in rats and rabbits
► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe. Acute toxicity of yerba mate dried...
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| Published in | Food and chemical toxicology Vol. 50; no. 2; pp. 328 - 334 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
01.02.2012
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| Abstract | ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe.
Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. |
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| AbstractList | Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe. Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. |
| Author | Maraschin, Marcelo Andrade, Fernanda de Albuquerque, Claudia Almeida Coelho de da Silva, Edson Luiz |
| Author_xml | – sequence: 1 givenname: Fernanda de surname: Andrade fullname: Andrade, Fernanda de organization: Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil – sequence: 2 givenname: Claudia Almeida Coelho de surname: Albuquerque fullname: Albuquerque, Claudia Almeida Coelho de organization: Department of Phytotechny, Regional University of Blumenau, Blumenau-SC, Brazil – sequence: 3 givenname: Marcelo surname: Maraschin fullname: Maraschin, Marcelo organization: Department of Plant Science, Agrarian Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil – sequence: 4 givenname: Edson Luiz surname: da Silva fullname: da Silva, Edson Luiz email: edson@ccs.ufsc.br organization: Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil |
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| Cites_doi | 10.1080/19440041003587310 10.1016/j.jep.2010.06.032 10.1177/1099800405280521 10.1021/ac50064a004 10.1002/cbdv.200800153 10.1590/S0103-50532005000500007 10.1111/j.1750-3841.2007.00535.x 10.1590/S1020-49892009000600010 10.1016/S0076-6879(99)99017-1 10.1021/jf8011085 10.1021/jf801041f 10.1093/mutage/gen011 10.1021/jf901660g 10.1158/1055-9965.EPI-08-0025 10.1093/jn/136.11.2791 10.1016/j.mrfmmm.2004.03.002 10.1097/00001648-199411000-00005 10.1016/j.yrtph.2010.08.021 10.1038/oby.2009.189 |
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| Keywords | MCV Rabbits AST ALP Toxicity Rats ALT Ilex paraguariensis UA Yerba mate TB TC RBC MCH TG GGT MCHC WBC TP YMDE CRN Dried extract |
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| References | Heck, De Mejia (b0050) 2007; 72 Mackenzie, Belcher, Sykes, Frame, Mukerji, Gillies (b0080) 2010; 58 Singleton, Orthofer, Lamuela Raventos (b0135) 1999; 299 Bastos, Oliveira, Matsumoto, Carvalho, Ribeiro (b0020) 2007; 1 Paganini-Stein, Schmidt, Furlong, Soares, Soares, Vaz, Muccillo-Baish (b0105) 2005; 7 associated to nutritional counseling in dyslipidemic subjects on statin therapy. Thesis. Federal University of Santa Catarina, Brazil, 2010. Gonçalves, Silva, Aguiar, Dimech, Rolim-Neto, Fraga, Lafayette, Wanderley (b0040) 2007; 26 Stefanuto, A. Hypocholesterolemic effect of yerba mate Vieira, Maraschin, Rovaris, Amboni, Simas, Pagliosa, Xavier, Amante (b0150) 2010; 27 Lima, Costa-Silva, Lyra, Araújo, Arruda, Dimech, Evêncio, Fraga, Lafayette, Wanderley (b0070) 2006; 25 Martins, Noso, Porto, Curiel, Gamberto, Bastos, Ribeiro, Carvalho (b0085) 2009; 18 American Chemical Society (ACS), 1980. Subcommittee on Environmental Analytical Chemistry. Guidelines for data acquisition and data quality evaluation in environmental chemistry. Anal. Chem. 52, 2242-2249. Ramirez-Mares, Chandra, De Mejia (b0115) 2004; 554 Brazil, 1996 Agência Nacional de Vigilância Sanitária. Resolução – n° 116 – Normas para estudo da toxicidade de produtos fitoterápicos, de 08/08/1996. Diário Oficial da República Federativa do Brasil, Poder Executivo, Brasília, DF. ICH Q2B, 1995. Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation Research. Guidance for industry: ICH Q2B Validation of analytical procedures: methodology. Rockville, (CPMP/ICH/281/95). OGA (b0100) 2003 Harkness, Wagner (b0045) 1993 Williams, Beutler, Erslev, Rundles (b0160) 2001 Leitao, Braga (b0065) 1994; 27 Vieira, Rovaris, Maraschin, Simas, Pagliosa, Podestá, Amboni, Barreto, Amante (b0145) 2008; 56 Loria, Barrios, Zanetti (b0075) 2009; 25 Sewram, De Stefani, Brennan, Boffetta (b0120) 2003; 12 Wang, Noh, Koo (b0155) 2006; 136 Morais, Stefanuto, Klein, Boaventura, Andrade, Wazlawik, Di Pietro, Maraschin, Silva (b0090) 2009; 57 Strassmann, Vieira, Pedrotti, Morais, Dias, Maraschin (b0130) 2008; 56 Yoshikawa, Sugimoto, Kato, Nakamura, Wang, Yamashita, Matsuda (b0165) 2009; 6 De Stefani, E., Correa, P.,Oreggia, F., Deneo-Pellegrini, H., Fernandez, G., Zavala, D., Carzoglio, J., Leiva, J., Fonthan, E., Rivero, S., 1988. Black tobacco, wine and mate in oropharyngeal cancer. A case–control study from Uruguay. Rev. Epidém. Santé Publ. 36, 389-394. Pintos, Franco, Oliveira, Kowalski, Curado, Dewar (b0110) 1994; 5 Gnoato, Schenkel, Bassani (b0035) 2005; 16 Bracesco, Sanchez, Contreras, Menini, Gugliucchi (b0025) 2011; 136 Miranda, Arçari, Pedrazzoli, Carvalho, Cerutti, Bastos, Ribeiro (b0095) 2008; 23 Brazil, 2004, Agência Nacional de Vigilância Sanitária. Resolução – Guia para a realização de estudos de toxicidade pré-clínica de fitoterápicos, de 16/03/2004. Diário Oficial da República Federativa do Brasil, Poder Executivo, Brasília, DF. Kamangar, Schantz, Abnet, Fagundes, Dawsey (b0060) 2008; 17 Vassallo, Correa, De Stéfani, Cendám, Zavala, Chen, Carzoglio, Deneo-Pellegrini (b0140) 1985; 75 Williams (10.1016/j.fct.2011.08.028_b0160) 2001 Bracesco (10.1016/j.fct.2011.08.028_b0025) 2011; 136 Martins (10.1016/j.fct.2011.08.028_b0085) 2009; 18 Gonçalves (10.1016/j.fct.2011.08.028_b0040) 2007; 26 Singleton (10.1016/j.fct.2011.08.028_b0135) 1999; 299 Vieira (10.1016/j.fct.2011.08.028_b0145) 2008; 56 10.1016/j.fct.2011.08.028_b0055 10.1016/j.fct.2011.08.028_b0010 10.1016/j.fct.2011.08.028_b0030 Loria (10.1016/j.fct.2011.08.028_b0075) 2009; 25 Pintos (10.1016/j.fct.2011.08.028_b0110) 1994; 5 Vieira (10.1016/j.fct.2011.08.028_b0150) 2010; 27 Leitao (10.1016/j.fct.2011.08.028_b0065) 1994; 27 Kamangar (10.1016/j.fct.2011.08.028_b0060) 2008; 17 Ramirez-Mares (10.1016/j.fct.2011.08.028_b0115) 2004; 554 10.1016/j.fct.2011.08.028_b0015 Bastos (10.1016/j.fct.2011.08.028_b0020) 2007; 1 Sewram (10.1016/j.fct.2011.08.028_b0120) 2003; 12 Mackenzie (10.1016/j.fct.2011.08.028_b0080) 2010; 58 Wang (10.1016/j.fct.2011.08.028_b0155) 2006; 136 Harkness (10.1016/j.fct.2011.08.028_b0045) 1993 OGA (10.1016/j.fct.2011.08.028_b0100) 2003 Morais (10.1016/j.fct.2011.08.028_b0090) 2009; 57 Paganini-Stein (10.1016/j.fct.2011.08.028_b0105) 2005; 7 Heck (10.1016/j.fct.2011.08.028_b0050) 2007; 72 Lima (10.1016/j.fct.2011.08.028_b0070) 2006; 25 Yoshikawa (10.1016/j.fct.2011.08.028_b0165) 2009; 6 Vassallo (10.1016/j.fct.2011.08.028_b0140) 1985; 75 10.1016/j.fct.2011.08.028_b0005 10.1016/j.fct.2011.08.028_b0125 Miranda (10.1016/j.fct.2011.08.028_b0095) 2008; 23 Strassmann (10.1016/j.fct.2011.08.028_b0130) 2008; 56 Gnoato (10.1016/j.fct.2011.08.028_b0035) 2005; 16 |
| References_xml | – volume: 5 start-page: 583 year: 1994 end-page: 590 ident: b0110 article-title: Mate, coffee, and tea consumption and risk of cancers of the upper aerodigestive tract in southern Brazil publication-title: Epidemiology contributor: fullname: Dewar – volume: 299 start-page: 152 year: 1999 end-page: 178 ident: b0135 article-title: Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteau reagent publication-title: Methods Enzymol. contributor: fullname: Lamuela Raventos – volume: 136 start-page: 2791 year: 2006 end-page: 2796 ident: b0155 article-title: Epigallocatechin gallate and caffeine differentially inhibit the intestinal absorption of cholesterol and fat in ovariectomized rats publication-title: J. Nutr. contributor: fullname: Koo – year: 2001 ident: b0160 article-title: Hematology contributor: fullname: Rundles – volume: 18 start-page: 42 year: 2009 end-page: 47 ident: b0085 article-title: Mate tea inhibits publication-title: Obesity contributor: fullname: Carvalho – volume: 23 start-page: 261 year: 2008 end-page: 265 ident: b0095 article-title: Protective effects of mate tea ( publication-title: Mutagenesis contributor: fullname: Ribeiro – volume: 27 start-page: 776 year: 2010 end-page: 782 ident: b0150 article-title: Quantification of polycyclic aromatic hydrocarbons throughout the processing stages of erva-mate ( publication-title: Food Addit. Contam. contributor: fullname: Amante – volume: 1 start-page: 37 year: 2007 end-page: 46 ident: b0020 article-title: Yerba mate: Pharmacological properties, research and biotechnology publication-title: Med. Arom. Plant. Sci. Biotechnol. contributor: fullname: Ribeiro – volume: 554 start-page: 53 year: 2004 end-page: 65 ident: b0115 article-title: chemo preventive activity of Camellia sinensis, publication-title: Mutat. Res. contributor: fullname: De Mejia – volume: 72 start-page: 138 year: 2007 end-page: 151 ident: b0050 article-title: Yerba mate tea ( publication-title: J. Food Sci. contributor: fullname: De Mejia – volume: 136 start-page: 378 year: 2011 end-page: 384 ident: b0025 article-title: Recent advances on publication-title: J. Ethnopharmacol. contributor: fullname: Gugliucchi – volume: 58 start-page: 490 year: 2010 end-page: 500 ident: b0080 article-title: Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study publication-title: Regul. Toxicol. Pharmacol. contributor: fullname: Gillies – volume: 25 start-page: 530 year: 2009 end-page: 539 ident: b0075 article-title: Cancer and yerba mate consumption: a review of possible associations publication-title: Rev. Panam. Salud Pública. contributor: fullname: Zanetti – year: 2003 ident: b0100 article-title: Fundamentos de Toxicologia contributor: fullname: OGA – volume: 57 start-page: 8316 year: 2009 end-page: 8324 ident: b0090 article-title: Consumption of yerba mate ( publication-title: J. Agric. Food Chem. contributor: fullname: Silva – volume: 26 start-page: 369 year: 2007 end-page: 374 ident: b0040 article-title: Avaliação toxicológica crônica do extrato hidroalcoólico de publication-title: Lat. Am. J. Pharm. contributor: fullname: Wanderley – volume: 75 start-page: 1005 year: 1985 end-page: 1009 ident: b0140 article-title: Esophageal cancer in Uruguay, a case – control study publication-title: J. Natl. Cancer Inst. contributor: fullname: Deneo-Pellegrini – volume: 56 start-page: 8348 year: 2008 end-page: 8353 ident: b0130 article-title: Quantitation of methylxanthinic alkaloids and phenolic compounds in mate ( publication-title: J. Agric. Food Chem. contributor: fullname: Maraschin – volume: 56 start-page: 4637 year: 2008 end-page: 4642 ident: b0145 article-title: Chemical characterization of candy made of erva-mate ( publication-title: J. Agric. Food Chem. contributor: fullname: Amante – year: 1993 ident: b0045 article-title: Biologia e Clínica de Coelhos e Roedores contributor: fullname: Wagner – volume: 6 start-page: 903 year: 2009 end-page: 915 ident: b0165 article-title: Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant ( publication-title: Chem. Biodiv. contributor: fullname: Matsuda – volume: 16 start-page: 723 year: 2005 end-page: 726 ident: b0035 article-title: HPLC method to assay total saponins in publication-title: J. Bras. Chem. Soc. contributor: fullname: Bassani – volume: 7 start-page: 146 year: 2005 end-page: 156 ident: b0105 article-title: Vascular responses to extractable fractions of publication-title: Biol. Res. Nurs. contributor: fullname: Muccillo-Baish – volume: 27 start-page: 1517 year: 1994 end-page: 1525 ident: b0065 article-title: Mutagenic and genotoxic effects of mate ( publication-title: Braz. J. Med. Biol. Res. contributor: fullname: Braga – volume: 12 start-page: 508 year: 2003 end-page: 513 ident: b0120 article-title: Mate consumption and the risk of squamous cell esophageal cancer in Uruguay publication-title: Cancer Epidemiol. Biomark. Prev. contributor: fullname: Boffetta – volume: 25 start-page: 544 year: 2006 end-page: 549 ident: b0070 article-title: Atividade cicatrizante e estudo toxicológico pré-clínico do fitoterápico sanativo publication-title: Acta Pharm. Bonaerense. contributor: fullname: Wanderley – volume: 17 start-page: 1262 year: 2008 end-page: 1268 ident: b0060 article-title: High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks publication-title: Cancer Epi. Biomark. Prevent. contributor: fullname: Dawsey – year: 1993 ident: 10.1016/j.fct.2011.08.028_b0045 contributor: fullname: Harkness – volume: 27 start-page: 776 year: 2010 ident: 10.1016/j.fct.2011.08.028_b0150 article-title: Quantification of polycyclic aromatic hydrocarbons throughout the processing stages of erva-mate (Ilex paraguariensis) publication-title: Food Addit. Contam. doi: 10.1080/19440041003587310 contributor: fullname: Vieira – volume: 136 start-page: 378 year: 2011 ident: 10.1016/j.fct.2011.08.028_b0025 article-title: Recent advances on Ilex paraguariensis research: minireview publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2010.06.032 contributor: fullname: Bracesco – volume: 7 start-page: 146 year: 2005 ident: 10.1016/j.fct.2011.08.028_b0105 article-title: Vascular responses to extractable fractions of Ilex paraguariensis in rats fed standard and high-cholesterol diets publication-title: Biol. Res. Nurs. doi: 10.1177/1099800405280521 contributor: fullname: Paganini-Stein – ident: 10.1016/j.fct.2011.08.028_b0005 doi: 10.1021/ac50064a004 – volume: 6 start-page: 903 year: 2009 ident: 10.1016/j.fct.2011.08.028_b0165 article-title: Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis) publication-title: Chem. Biodiv. doi: 10.1002/cbdv.200800153 contributor: fullname: Yoshikawa – volume: 16 start-page: 723 year: 2005 ident: 10.1016/j.fct.2011.08.028_b0035 article-title: HPLC method to assay total saponins in Ilex paraguariensis aqueous extract publication-title: J. Bras. Chem. Soc. doi: 10.1590/S0103-50532005000500007 contributor: fullname: Gnoato – volume: 1 start-page: 37 year: 2007 ident: 10.1016/j.fct.2011.08.028_b0020 article-title: Yerba mate: Pharmacological properties, research and biotechnology publication-title: Med. Arom. Plant. Sci. Biotechnol. contributor: fullname: Bastos – volume: 72 start-page: 138 year: 2007 ident: 10.1016/j.fct.2011.08.028_b0050 article-title: Yerba mate tea (Ilex paraguariensis): a comprehensive on chemistry, health implications, and technological considerations publication-title: J. Food Sci. doi: 10.1111/j.1750-3841.2007.00535.x contributor: fullname: Heck – volume: 25 start-page: 530 year: 2009 ident: 10.1016/j.fct.2011.08.028_b0075 article-title: Cancer and yerba mate consumption: a review of possible associations publication-title: Rev. Panam. Salud Pública. doi: 10.1590/S1020-49892009000600010 contributor: fullname: Loria – volume: 299 start-page: 152 year: 1999 ident: 10.1016/j.fct.2011.08.028_b0135 article-title: Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteau reagent publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(99)99017-1 contributor: fullname: Singleton – year: 2001 ident: 10.1016/j.fct.2011.08.028_b0160 contributor: fullname: Williams – volume: 56 start-page: 4637 year: 2008 ident: 10.1016/j.fct.2011.08.028_b0145 article-title: Chemical characterization of candy made of erva-mate (Ilex paraguariensis A St. Hil.) residue publication-title: J. Agric. Food Chem. doi: 10.1021/jf8011085 contributor: fullname: Vieira – ident: 10.1016/j.fct.2011.08.028_b0125 – ident: 10.1016/j.fct.2011.08.028_b0010 – volume: 26 start-page: 369 year: 2007 ident: 10.1016/j.fct.2011.08.028_b0040 article-title: Avaliação toxicológica crônica do extrato hidroalcoólico de Operculina Alata (Ham.) Urban sobre os parâmetros bioquímicos e hematológicos em ratas wistar publication-title: Lat. Am. J. Pharm. contributor: fullname: Gonçalves – volume: 56 start-page: 8348 year: 2008 ident: 10.1016/j.fct.2011.08.028_b0130 article-title: Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos publication-title: J. Agric. Food Chem. doi: 10.1021/jf801041f contributor: fullname: Strassmann – volume: 23 start-page: 261 year: 2008 ident: 10.1016/j.fct.2011.08.028_b0095 article-title: Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice publication-title: Mutagenesis doi: 10.1093/mutage/gen011 contributor: fullname: Miranda – volume: 12 start-page: 508 year: 2003 ident: 10.1016/j.fct.2011.08.028_b0120 article-title: Mate consumption and the risk of squamous cell esophageal cancer in Uruguay publication-title: Cancer Epidemiol. Biomark. Prev. contributor: fullname: Sewram – volume: 57 start-page: 8316 year: 2009 ident: 10.1016/j.fct.2011.08.028_b0090 article-title: Consumption of yerba mate (Ilex paraguariensis) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy publication-title: J. Agric. Food Chem. doi: 10.1021/jf901660g contributor: fullname: Morais – volume: 17 start-page: 1262 year: 2008 ident: 10.1016/j.fct.2011.08.028_b0060 article-title: High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks publication-title: Cancer Epi. Biomark. Prevent. doi: 10.1158/1055-9965.EPI-08-0025 contributor: fullname: Kamangar – volume: 136 start-page: 2791 year: 2006 ident: 10.1016/j.fct.2011.08.028_b0155 article-title: Epigallocatechin gallate and caffeine differentially inhibit the intestinal absorption of cholesterol and fat in ovariectomized rats publication-title: J. Nutr. doi: 10.1093/jn/136.11.2791 contributor: fullname: Wang – volume: 25 start-page: 544 year: 2006 ident: 10.1016/j.fct.2011.08.028_b0070 article-title: Atividade cicatrizante e estudo toxicológico pré-clínico do fitoterápico sanativo publication-title: Acta Pharm. Bonaerense. contributor: fullname: Lima – volume: 554 start-page: 53 year: 2004 ident: 10.1016/j.fct.2011.08.028_b0115 article-title: In vitro chemo preventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2004.03.002 contributor: fullname: Ramirez-Mares – volume: 27 start-page: 1517 year: 1994 ident: 10.1016/j.fct.2011.08.028_b0065 article-title: Mutagenic and genotoxic effects of mate (Ilex paraguariensis) in prokaryotic organisms publication-title: Braz. J. Med. Biol. Res. contributor: fullname: Leitao – year: 2003 ident: 10.1016/j.fct.2011.08.028_b0100 contributor: fullname: OGA – ident: 10.1016/j.fct.2011.08.028_b0055 – volume: 75 start-page: 1005 year: 1985 ident: 10.1016/j.fct.2011.08.028_b0140 article-title: Esophageal cancer in Uruguay, a case – control study publication-title: J. Natl. Cancer Inst. contributor: fullname: Vassallo – volume: 5 start-page: 583 year: 1994 ident: 10.1016/j.fct.2011.08.028_b0110 article-title: Mate, coffee, and tea consumption and risk of cancers of the upper aerodigestive tract in southern Brazil publication-title: Epidemiology doi: 10.1097/00001648-199411000-00005 contributor: fullname: Pintos – volume: 58 start-page: 490 year: 2010 ident: 10.1016/j.fct.2011.08.028_b0080 article-title: Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2010.08.021 contributor: fullname: Mackenzie – ident: 10.1016/j.fct.2011.08.028_b0015 – ident: 10.1016/j.fct.2011.08.028_b0030 – volume: 18 start-page: 42 year: 2009 ident: 10.1016/j.fct.2011.08.028_b0085 article-title: Mate tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice publication-title: Obesity doi: 10.1038/oby.2009.189 contributor: fullname: Martins |
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| Snippet | ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was... Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric... |
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| SubjectTerms | acute toxicity behavior change blood serum body weight Dried extract histopathology Ilex paraguariensis intragastric administration kidneys liver monitoring New Zealand White rabbit oral administration Rabbits Rats safety assessment stomach subchronic toxicity Toxicity toxicity testing Yerba mate |
| Title | Safety assessment of yerba mate (Ilex paraguariensis) dried extract: Results of acute and 90days subchronic toxicity studies in rats and rabbits |
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