Safety assessment of yerba mate (Ilex paraguariensis) dried extract: Results of acute and 90days subchronic toxicity studies in rats and rabbits
► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe. Acute toxicity of yerba mate dried...
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Published in | Food and chemical toxicology Vol. 50; no. 2; pp. 328 - 334 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.02.2012
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Abstract | ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe.
Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. |
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AbstractList | Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was investigated in animals. ► Results of our preclinical toxicological study showed that yerba mate extract is safe. Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration. |
Author | Maraschin, Marcelo Andrade, Fernanda de Albuquerque, Claudia Almeida Coelho de da Silva, Edson Luiz |
Author_xml | – sequence: 1 givenname: Fernanda de surname: Andrade fullname: Andrade, Fernanda de organization: Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil – sequence: 2 givenname: Claudia Almeida Coelho de surname: Albuquerque fullname: Albuquerque, Claudia Almeida Coelho de organization: Department of Phytotechny, Regional University of Blumenau, Blumenau-SC, Brazil – sequence: 3 givenname: Marcelo surname: Maraschin fullname: Maraschin, Marcelo organization: Department of Plant Science, Agrarian Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil – sequence: 4 givenname: Edson Luiz surname: da Silva fullname: da Silva, Edson Luiz email: edson@ccs.ufsc.br organization: Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil |
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Keywords | MCV Rabbits AST ALP Toxicity Rats ALT Ilex paraguariensis UA Yerba mate TB TC RBC MCH TG GGT MCHC WBC TP YMDE CRN Dried extract |
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Snippet | ► Yerba mate infusion has been used as stimulant against physical and mental weakness. ► Acute and subchronic toxicity of yerba mate dried extract was... Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric... |
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SubjectTerms | acute toxicity behavior change blood serum body weight Dried extract histopathology Ilex paraguariensis intragastric administration kidneys liver monitoring New Zealand White rabbit oral administration Rabbits Rats safety assessment stomach subchronic toxicity Toxicity toxicity testing Yerba mate |
Title | Safety assessment of yerba mate (Ilex paraguariensis) dried extract: Results of acute and 90days subchronic toxicity studies in rats and rabbits |
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