Enhancement of dissolution and bioavailability of ezetimibe by amorphous solid dispersion nanoparticles fabricated using supercritical antisolvent process

• Published in: Journal of pharmaceutical investigation Vol. 45; no. 7; pp. 641 - 649
• Main Authors: Ha, Eun-Sol, Kim, Jeong-Soo, Baek, In-hwan, Hwang, Sung-Joo, Kim, Min-Soo
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2015; 한국약제학회
• Subjects: Biomedical and Life Sciences; Biomedicine; Original Article; 약학; Solid dispersion; Supercritical technology; Bioavailability; Ezetimibe

The purpose of the present study was to fabricate ezetimibe-hydroxypropyl cellulose (HPC) solid dispersion nanoparticles with enhanced dissolution and oral bioavailability using the supercritical antisolvent (SAS) process. We investigated the influence of SAS process parameters (pressure, temperatur...