Tolerance of porcine renal allografts induced by donor spleen cells and seven days' treatment with cyclosporine

Liver allografts in pigs and in rats elicit a substantial cellular immune response that can resolve spontaneously with the induction of donor-specific systemic tolerance. Self-limiting interactions between host and donor (graft)-derived leukocytes may be the basis for tolerogenesis. We have attempte...

Full description

Saved in:
Bibliographic Details
Published inTransplantation Vol. 57; no. 10; p. 1433
Main Authors Calne, R Y, Watson, C J, Brons, I G, Makisalo, H, Metcalfe, S M, Sriwatanawongsa, V, Davies, H S
Format Journal Article
LanguageEnglish
Published United States 27.05.1994
Subjects
Animals
Cyclosporine - therapeutic use
Female
Graft Survival
Immunosuppression - methods
Kidney Transplantation - immunology
Lymphocyte Culture Test, Mixed
Skin Transplantation - immunology
Spleen - immunology
Swine
Online AccessGet more information

Cover

More Information
Summary:Liver allografts in pigs and in rats elicit a substantial cellular immune response that can resolve spontaneously with the induction of donor-specific systemic tolerance. Self-limiting interactions between host and donor (graft)-derived leukocytes may be the basis for tolerogenesis. We have attempted to reproduce this effect of liver grafting in pigs by peroperative infusion of donor leukocytes into kidney graft recipients given an interrupted short course of CsA designed to promote donor leukocyte survival and interaction with host cells. This protocol can secure long-term kidney graft survival resistant to challenge by donor skin grafting. Donor skin is, however, rejected, but more slowly than third-party skin, indicating a degree of systemic specific unresponsiveness in these long-term kidney graft recipients.
ISSN:0041-1337
DOI:10.1097/00007890-199405270-00004