Detection of serum alterations in polysubstance use patients by FT-Raman spectroscopy

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 326; p. 125234
• Main Authors: Ünübol, Başak, Sarıbal, Devrim, Ceylan, Zeynep, Mırsal, Hasan, Depciuch, Joanna, Cebulski, Joseph, Guleken, Zozan
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.02.2025
• Subjects: Bio macromolecule changes; FT-Raman Spectroscopy; Partial Least Square Discriminate Analysis (PLS-DA); Polysubstance use; Principal Component Analysis (PCA); ROC analysis; FT-Raman Spectroscopy; Polysubstance use; Principal Component Analysis (PCA); Partial Least Square Discriminate Analysis (PLS-DA); Bio macromolecule changes; ROC analysis

[Display omitted] •Raman spectroscopy reveals polysubstance abuse effects.•Polysubstance use groups showed peak shifts in polysaccharides, amides, and lipid vibrations.•Substance use groups showed increased lipid vibrations, unlike control subjects, who dominated in amide fractions.•ROC analysis sho...