Ablation of Akt2 rescues chronic caloric restriction-provoked myocardial remodeling and dysfunction through a CDK1-mediated regulation of mitophagy

• Published in: Life sciences (1973) Vol. 356; p. 123021
• Main Authors: Wu, Min, Chen, Zhao, Zhu, Jiade, Lin, Jie, Wu, Ne N., Han, Xuefeng, Wang, Mengyuan, Reiter, Russel J., Zhang, Yingmei, Wu, Yijin, Ren, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2024
• Subjects: Akt2; Cardiac; Glucocorticoids; Mitophagy; Sustained caloric restriction; Glucocorticoids; Mitophagy; Cardiac; Akt2; Sustained caloric restriction

Chronic caloric restriction triggers unfavorable alterations in cardiac function albeit responsible scenarios remain unclear. This work evaluated the possible involvement of Akt2 in caloric restriction-evoked cardiac geometric and functional changes and responsible processes focusing on autophagy an...