TNF-α blockage prevents late neurological consequences of Zika virus infection in mice

• Published in: Behavioural brain research Vol. 471; p. 115114
• Main Authors: Christoff, Raissa R., Liesner, Isabelle L., Gavino-Leopoldino, Daniel, Andrade, Bruna, Oliveira de Campos, Beatriz, Salgado, Isabella, Simões-Lemos, Felipe, Da Poian, Andrea T., Assunção-Miranda, Iranaia, Figueiredo, Claudia P., Clarke, Julia R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.08.2024
• Subjects: Congenital zika syndrome; Infliximab; Microcephaly; Motor impairment, seizures; Neuroinflammation; TNF-α; Neuroinflammation; Congenital zika syndrome; Motor impairment, seizures; TNF-α; Infliximab; Microcephaly

Zika virus (ZIKV) is a neurotropic Orthoflavivirus that causes a myriad of neurological manifestations in newborns exposed in uterus. Despite the devastating consequences of ZIKV on the developing brain, strategies to prevent or treat the consequences of viral infection are not yet available. We pre...