Global to local influences on temporal expectation in marmosets and humans

• Published in: Current biology Vol. 35; no. 5; pp. 1095 - 1106.e7
• Main Authors: Dragoi, Tudor, Sugihara, Hiroki, Le, Nhat Minh, Adam, Elie, Sharma, Jitendra, Feng, Guoping, Desimone, Robert, Sur, Mriganka
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 10.03.2025
• Subjects: Animals; Bayes Theorem; bayesian model; Callithrix - physiology; Callithrix - psychology; Cognition - physiology; Decision Making; dynamic hazard model; Female; foreperiod paradigm; hazard rate model; Humans; internal models; Learning; Male; Marmosets; Reaction Time; temporal expectation; trial history; Marmosets; temporal expectation; hazard rate model; reaction time; trial history; internal models; bayesian model; dynamic hazard model; foreperiod paradigm
• DOI: 10.1016/j.cub.2025.01.052
• ISSN: 0960-9822; 1879-0445

Marmosets are emerging rapidly as experimental models for studying the neural bases of cognition and, importantly, for modeling disorders of human cognition, but many aspects of their mental attributes remain to be characterized. When judging elapsed time, humans implicitly use prior information to predict upcoming events and reduce perceptual and decision-making uncertainty. An influential model of temporal expectation is the hazard rate model, which posits the likelihood of an event occurring in the future, provided it has not occurred already. Here, we report that marmosets trained on a reaction time task acquire the hazard rate model of expectation, consistent with the global task structure. The model emerges progressively with learning but unexpectedly continues to be modified by local contingencies, as demonstrated by a serial effect of trial duration on responses. The combined effects of global and local task structure are well described by a multiple regression model and computationally by Bayesian updating of the hazard function. Parallel experiments in human subjects similarly demonstrate global followed by local influences on reaction times and temporal expectation. Thus, in both marmosets and humans, task history and local structure continuously update task-specific responses, surprisingly at the expense of optimal responses after the competent acquisition of an internal model. •Marmosets and humans share similar internal models of temporal expectation•Animals first acquire global then local features of temporal expectation•Temporal expectation can be explained by a Bayesian-based hazard rate model Dragoi et al. utilize a timing task in marmosets and humans to show that both species share similar internal models of temporal expectation. Animals first acquire global and then local features of temporal expectation, which they show can be explained by a Bayesian-based hazard rate model.