Lymphotoxin-α Gene 252G Allelic Variant Is a Risk Factor for Large-Vessel-Associated Ischemic Stroke

• Published in: Journal of molecular neuroscience Vol. 27; no. 2; pp. 205 - 212
• Main Authors: Szolnoki, Zoltán, Havasi, Viktória, Talián, Gábor, Bene, Judit, Komlósi, Katalin, Somogyvári, Ferenc, Kondacs, András, Szabó, Mihály, Fodor, Lajos, Bodor, Anita, Melegh, Béla
• Format: Journal Article
• Language: English
• Published: United States 2005
• Subjects: Aged; Alleles; Blood Vessels - pathology; Brain Ischemia - genetics; Brain Ischemia - physiopathology; Female; Genetic Predisposition to Disease; Genotype; Humans; Lymphotoxin-alpha - genetics; Lymphotoxin-alpha - metabolism; Male; Middle Aged; Regression Analysis; Risk Factors; Stroke - genetics; Stroke - physiopathology

A direct role of lymphotoxin-alpha (LTA) in promoting atherosclerotic plaque growth has been demonstrated recently. The different protein transcripts of the naturally occurring genetic variants of the LTA gene have been demonstrated to exhibit affected functions, and an allelic difference in binding...