Large-scale chemical and enzymatic synthesis of a Clostridium difficile toxin a binding trisaccharide

• Published in: Synthesis (Stuttgart) no. 14; pp. 2293 - 2296
• Main Authors: Ratcliffe, RM, Kamath, VP, Yeske, RE, Gregson, JM, Fang, YR, Palcic, MM
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 01.10.2004
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; iso-globo trisaccharide; HYDROXYL GROUP; Gal(alpha 1,3)Gal epitope; OLIGOSACCHARIDES; FUSION; Clostridium difficile toxin A; TETRASACCHARIDE; galactosyltransferase; CHEMOENZYMATIC SYNTHESIS; CATALYZED SYNTHESIS; LACTOSAMINE; RECEPTOR

Trisaccharide 1, 8-methoxycarbonyloctyl-O-(alpha-D-galactopyranosyl)-(1-->3)-(beta-D-galactopyranosyl)-(1-->4)-beta-D-glucopyranoside, linked to a solid support can be used to remove Clostridium diffcile toxin A from the intestinal tract. Therefore, multi-gram chemical and enzymatic synthesis...