Anti-allergic and Anti-hyperglycemic Potentials of Lumnitzera racemose Leaves: In vivo and In silico Studies
Lumnitzera racemosa a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the anti-allergic and anti-hyperglycemic activities and also the responsible polyphenols for these potentials. Anti-allergic activity was evaluated on tolue...
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Published in | National Academy of Sciences, India. Proceedings. Section B. Biological Sciences Vol. 93; no. 1; pp. 147 - 158 |
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Main Authors | , , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New Delhi
Springer India
01.03.2023
Springer Nature B.V |
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Abstract | Lumnitzera racemosa
a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the anti-allergic and anti-hyperglycemic activities and also the responsible polyphenols for these potentials. Anti-allergic activity was evaluated on toluene 2,4-diisocyanate (TDI)-induced allergic model mice and anti-diabetic activity on streptozotocin (STZ)-induced diabetic mice. Natural polyphenolic compounds were determined by HPLC–DAD. In addition, in silico molecular docking was conducted via ‘Vina Wizard’ program in PyRx–Python Prescription 0.8 on nine isolated compounds against histamine H
1
receptor (H
1
R) and sulfonylurea receptor 1 (SUR1). Acute toxicity study confirmed the safety of the leaves extract up to 3000 mg/kg dose in mice. Different biochemical parameters were also in normal at a dose of 500 mg/kg in sub-acute toxicity study. The leaves extract significantly suppressed (
P
< 0.05) TDI-induced allergy-like symptoms. The total and differential counts of WBC in blood and broncho alveolar lavage fluid (BALF) were also decreased in extract treated allergic mice. In STZ-induced diabetic mice, the extract significantly reduced the level of blood glucose and different related biomarkers. HPLC profiling revealed the presence of nine phenolic compounds; among these myricetin and rosmarinic acid demonstrated the best docking score − 8.4 kcal/mol against H
1
R whereas − 7.3 kcal/mol for standard drug cetirizine. On the other hand, rutin hydrate exhibited best docking score − 10.2 kcal/mol against SUR1, whereas standard drug glibenclamide showed − 8.4 kcal/mol. In conclusion,
L. racemosa
is safe and rich in different polyphenolic compounds which were found effective against allergy and diabetes. |
---|---|
AbstractList | Lumnitzera racemosa a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the anti-allergic and anti-hyperglycemic activities and also the responsible polyphenols for these potentials. Anti-allergic activity was evaluated on toluene 2,4-diisocyanate (TDI)-induced allergic model mice and anti-diabetic activity on streptozotocin (STZ)-induced diabetic mice. Natural polyphenolic compounds were determined by HPLC–DAD. In addition, in silico molecular docking was conducted via ‘Vina Wizard’ program in PyRx–Python Prescription 0.8 on nine isolated compounds against histamine H1 receptor (H1R) and sulfonylurea receptor 1 (SUR1). Acute toxicity study confirmed the safety of the leaves extract up to 3000 mg/kg dose in mice. Different biochemical parameters were also in normal at a dose of 500 mg/kg in sub-acute toxicity study. The leaves extract significantly suppressed (P < 0.05) TDI-induced allergy-like symptoms. The total and differential counts of WBC in blood and broncho alveolar lavage fluid (BALF) were also decreased in extract treated allergic mice. In STZ-induced diabetic mice, the extract significantly reduced the level of blood glucose and different related biomarkers. HPLC profiling revealed the presence of nine phenolic compounds; among these myricetin and rosmarinic acid demonstrated the best docking score − 8.4 kcal/mol against H1R whereas − 7.3 kcal/mol for standard drug cetirizine. On the other hand, rutin hydrate exhibited best docking score − 10.2 kcal/mol against SUR1, whereas standard drug glibenclamide showed − 8.4 kcal/mol. In conclusion, L. racemosa is safe and rich in different polyphenolic compounds which were found effective against allergy and diabetes. Lumnitzera racemosa a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the anti-allergic and anti-hyperglycemic activities and also the responsible polyphenols for these potentials. Anti-allergic activity was evaluated on toluene 2,4-diisocyanate (TDI)-induced allergic model mice and anti-diabetic activity on streptozotocin (STZ)-induced diabetic mice. Natural polyphenolic compounds were determined by HPLC–DAD. In addition, in silico molecular docking was conducted via ‘Vina Wizard’ program in PyRx–Python Prescription 0.8 on nine isolated compounds against histamine H 1 receptor (H 1 R) and sulfonylurea receptor 1 (SUR1). Acute toxicity study confirmed the safety of the leaves extract up to 3000 mg/kg dose in mice. Different biochemical parameters were also in normal at a dose of 500 mg/kg in sub-acute toxicity study. The leaves extract significantly suppressed ( P < 0.05) TDI-induced allergy-like symptoms. The total and differential counts of WBC in blood and broncho alveolar lavage fluid (BALF) were also decreased in extract treated allergic mice. In STZ-induced diabetic mice, the extract significantly reduced the level of blood glucose and different related biomarkers. HPLC profiling revealed the presence of nine phenolic compounds; among these myricetin and rosmarinic acid demonstrated the best docking score − 8.4 kcal/mol against H 1 R whereas − 7.3 kcal/mol for standard drug cetirizine. On the other hand, rutin hydrate exhibited best docking score − 10.2 kcal/mol against SUR1, whereas standard drug glibenclamide showed − 8.4 kcal/mol. In conclusion, L. racemosa is safe and rich in different polyphenolic compounds which were found effective against allergy and diabetes. |
Author | Acharyya, Rabindra Nath Mithila, Shuvra Rani, Suborna Islam, Md. Arman Dev, Shrabanti Golder, Mimi Das, Asish Kumar Hossain, Hemayet Ahmed, Khondoker Shahin |
Author_xml | – sequence: 1 givenname: Rabindra Nath surname: Acharyya fullname: Acharyya, Rabindra Nath organization: Pharmacy Discipline, Khulna University – sequence: 2 givenname: Shuvra surname: Mithila fullname: Mithila, Shuvra organization: Pharmacy Discipline, Khulna University – sequence: 3 givenname: Suborna surname: Rani fullname: Rani, Suborna organization: Pharmacy Discipline, Khulna University – sequence: 4 givenname: Md. Arman surname: Islam fullname: Islam, Md. Arman organization: Pharmacy Discipline, Khulna University – sequence: 5 givenname: Mimi surname: Golder fullname: Golder, Mimi organization: Pharmacy Discipline, Khulna University – sequence: 6 givenname: Khondoker Shahin surname: Ahmed fullname: Ahmed, Khondoker Shahin organization: Bangladesh Council of Scientific and Industrial Research (BCSIR) – sequence: 7 givenname: Hemayet surname: Hossain fullname: Hossain, Hemayet organization: Bangladesh Council of Scientific and Industrial Research (BCSIR) – sequence: 8 givenname: Shrabanti surname: Dev fullname: Dev, Shrabanti organization: Pharmacy Discipline, Khulna University – sequence: 9 givenname: Asish Kumar surname: Das fullname: Das, Asish Kumar email: dasasish03@yahoo.com organization: Pharmacy Discipline, Khulna University |
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Cites_doi | 10.1016/S0014-2999(99)00803-1 10.1016/S0091-6749(05)80223-4 10.1111/j.1365-2222.1996.tb00553.x 10.1034/j.1398-9995.1999.00910.x 10.1248/cpb.c15-00830 10.1111/j.1365-2230.2004.01618.x 10.1016/j.sjbs.2017.03.002 10.1093/nar/28.1.235 10.1155/2013/716073 10.1007/s002440010223 10.1254/jphs.09003 10.1021/jf990767e 10.4314/tjpr.v13i1.15 10.3998/ark.5550190.0004.304 10.1152/ajpendo.00566.2012 10.1080/15476910701337472 10.1016/j.tox.2006.07.016 10.1093/nar/gky1033 10.7324/JAPS.2017.70313 10.1164/ajrccm/136.2.379 10.1164/ajrccm.161.3.9809071 10.1159/000497588 10.2174/1871525716666180103163107 10.26538/tjnpr/v4i8.1 10.1007/978-1-4939-2269-7_19 |
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Snippet | Lumnitzera racemosa
a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the... Lumnitzera racemosa a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present study was designed to investigate the... |
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SubjectTerms | Acute toxicity Allergies Alveoli Animal models Asthma Behavioral Sciences Biomedical and Life Sciences Cetirizine Diabetes Diabetes mellitus Drug dosages Glibenclamide High-performance liquid chromatography Histamine H1 receptors Leaves Life Sciences Nucleic Acid Chemistry Phenolic compounds Plant Biochemistry Polyphenols Research Article Rosmarinic acid Rutin Streptozocin Sulfonylurea Toluene 2,4-diisocyanate |
Title | Anti-allergic and Anti-hyperglycemic Potentials of Lumnitzera racemose Leaves: In vivo and In silico Studies |
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