Leukotriene D4 induces cognitive impairment through enhancement of CysLT1R-mediated amyloid-β generation in mice

• Published in: Neuropharmacology Vol. 65; pp. 182 - 192
• Main Authors: Tang, Su-Su, Wang, Xiao-Yun, Hong, Hao, Long, Yan, Li, Yong-Qi, Xiang, Guo-Qing, Jiang, Li-Ying, Zhang, Han-Ting, Liu, Li-Ping, Miao, Ming-Xing, Hu, Mei, Zhang, Ting-Ting, Hu, Wei, Ji, Hui, Ye, Feng-Ying
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.02.2013
• Subjects: Alzheimer’s disease; Amyloid-β peptides; Cognition; Cysteinyl leukotriene receptor 1; Leukotriene D4; Leukotriene D4; Cognition; Alzheimer’s disease; Amyloid-β peptides; Cysteinyl leukotriene receptor 1

Amyloid plaques in the extracellular parenchyma mainly consist of amyloid-β peptides (Aβ), one of the pathological hallmarks in Alzheimer's disease (AD). In the present study, we examined neuroinflammation, amyloidogenesis, and memory performance following intracerebral infusions of leukotriene...