Development and Evaluation of Nano-Vesicular Emulsion-Based Gel as a Promising Approach for Dermal Atorvastatin Delivery Against Inflammation

• Published in: International journal of nanomedicine Vol. 19; pp. 11415 - 11432
• Main Authors: Abdallah, Marwa H, Shawky, Seham, Shahien, Mona M, El-Horany, Hemat El-Sayed, Ahmed, Enas Haridy, El-Housiny, Shaimaa
• Format: Journal Article
• Language: English
• Published: New Zealand Dove 01.01.2024
• Subjects: Administration, Cutaneous; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacokinetics; Anti-Inflammatory Agents - pharmacology; Atorvastatin - administration & dosage; Atorvastatin - chemistry; Atorvastatin - pharmacokinetics; Atorvastatin - pharmacology; Drug Liberation; Edema - drug therapy; Emulsions - chemistry; Gels - chemistry; Hypromellose Derivatives - chemistry; Inflammation - drug therapy; Male; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Original Research; Particle Size; Rats; Rats, Wistar; Skin - drug effects; Skin Absorption - drug effects; nano-vesicles; anti-inflammatory test; emulsion-based gel; histopathological study

Atorvastatin (ATV), a medication used to reduce cholesterol levels, possesses properties that can counteract the damaging effects of free radicals and reduce inflammation. However, the administration of ATV orally is associated with low systemic bioavailability due to its limited capacity to dissolv...