Bright Light Therapy as Augmentation of Pharmacotherapy for Treatment of Depression: A Systematic Review and Meta-Analysis

Bright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have efficacy in nonseasonal depressions. Also, there is evidence that bright light therapy may improve responsiveness to antidepressant pharmacoth...

Full description

Saved in:
Bibliographic Details
Published inPrimary care companion for CNS disorders Vol. 18; no. 5
Main Authors Penders, Thomas M, Stanciu, Cornel N, Schoemann, Alexander M, Ninan, Philip T, Bloch, Richard, Saeed, Sy A
Format Journal Article
LanguageEnglish
Published United States 20.10.2016
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Bright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have efficacy in nonseasonal depressions. Also, there is evidence that bright light therapy may improve responsiveness to antidepressant pharmacotherapy. We searched PubMed/MEDLINE, PsycINFO, PsycARTICLES, CINAHL, EMBASE, Scopus, and Academic OneFile for English-language literature published between January 1998 and April 2016, using the keywords bright light therapy AND major depression, bright light therapy AND depress*, bright light therapy AND bipolar depression, bright light therapy AND affective disorders, circadian rhythm AND major depression, circadian rhythm AND depress*, and circadian rhythm AND affective disorder. Studies that reported randomized trials comparing antidepressant pharmacotherapy with bright light therapy ≥ 5,000 lux for ≥ 30 minutes to antidepressant pharmacotherapy without bright light therapy for the treatment of nonseasonal depression were included. Studies of seasonal depression were excluded. Following review of the initial 112 returns, 2 of the authors independently judged each trial, applying the inclusionary and exclusionary criteria. Ten studies were selected as meeting these criteria. Subjects in these studies were pooled using standard techniques of meta-analysis. Ten studies involving 458 patients showed improvement using bright light therapy augmentation versus antidepressant pharmacotherapy alone. The effect size was similar to that of other accepted augmentation strategies, roughly 0.5. Analysis of pooled data from randomized trials provides evidence for the efficacy of use of bright light therapy ≥ 5,000 lux for periods ≥ 30 minutes when used as augmentation to standard antidepressant pharmacotherapy in the treatment of major depressive disorder and bipolar depression without a seasonal pattern.
AbstractList BACKGROUNDBright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have efficacy in nonseasonal depressions. Also, there is evidence that bright light therapy may improve responsiveness to antidepressant pharmacotherapy. DATA SOURCESWe searched PubMed/MEDLINE, PsycINFO, PsycARTICLES, CINAHL, EMBASE, Scopus, and Academic OneFile for English-language literature published between January 1998 and April 2016, using the keywords bright light therapy AND major depression, bright light therapy AND depress*, bright light therapy AND bipolar depression, bright light therapy AND affective disorders, circadian rhythm AND major depression, circadian rhythm AND depress*, and circadian rhythm AND affective disorder. STUDY SELECTION AND DATA EXTRACTIONStudies that reported randomized trials comparing antidepressant pharmacotherapy with bright light therapy ≥ 5,000 lux for ≥ 30 minutes to antidepressant pharmacotherapy without bright light therapy for the treatment of nonseasonal depression were included. Studies of seasonal depression were excluded. Following review of the initial 112 returns, 2 of the authors independently judged each trial, applying the inclusionary and exclusionary criteria. Ten studies were selected as meeting these criteria. Subjects in these studies were pooled using standard techniques of meta-analysis. RESULTSTen studies involving 458 patients showed improvement using bright light therapy augmentation versus antidepressant pharmacotherapy alone. The effect size was similar to that of other accepted augmentation strategies, roughly 0.5. CONCLUSIONSAnalysis of pooled data from randomized trials provides evidence for the efficacy of use of bright light therapy ≥ 5,000 lux for periods ≥ 30 minutes when used as augmentation to standard antidepressant pharmacotherapy in the treatment of major depressive disorder and bipolar depression without a seasonal pattern.
Bright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have efficacy in nonseasonal depressions. Also, there is evidence that bright light therapy may improve responsiveness to antidepressant pharmacotherapy. We searched PubMed/MEDLINE, PsycINFO, PsycARTICLES, CINAHL, EMBASE, Scopus, and Academic OneFile for English-language literature published between January 1998 and April 2016, using the keywords bright light therapy AND major depression, bright light therapy AND depress*, bright light therapy AND bipolar depression, bright light therapy AND affective disorders, circadian rhythm AND major depression, circadian rhythm AND depress*, and circadian rhythm AND affective disorder. Studies that reported randomized trials comparing antidepressant pharmacotherapy with bright light therapy ≥ 5,000 lux for ≥ 30 minutes to antidepressant pharmacotherapy without bright light therapy for the treatment of nonseasonal depression were included. Studies of seasonal depression were excluded. Following review of the initial 112 returns, 2 of the authors independently judged each trial, applying the inclusionary and exclusionary criteria. Ten studies were selected as meeting these criteria. Subjects in these studies were pooled using standard techniques of meta-analysis. Ten studies involving 458 patients showed improvement using bright light therapy augmentation versus antidepressant pharmacotherapy alone. The effect size was similar to that of other accepted augmentation strategies, roughly 0.5. Analysis of pooled data from randomized trials provides evidence for the efficacy of use of bright light therapy ≥ 5,000 lux for periods ≥ 30 minutes when used as augmentation to standard antidepressant pharmacotherapy in the treatment of major depressive disorder and bipolar depression without a seasonal pattern.
Author Bloch, Richard
Ninan, Philip T
Penders, Thomas M
Stanciu, Cornel N
Schoemann, Alexander M
Saeed, Sy A
Author_xml – sequence: 1
  givenname: Thomas M
  surname: Penders
  fullname: Penders, Thomas M
  email: penderst@ecu.edu
  organization: Department of Psychiatry and Behavioral Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
– sequence: 2
  givenname: Cornel N
  surname: Stanciu
  fullname: Stanciu, Cornel N
  organization: Department of Psychiatry and Behavioral Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
– sequence: 3
  givenname: Alexander M
  surname: Schoemann
  fullname: Schoemann, Alexander M
  organization: Department of Psychology, East Carolina University, Greenville, North Carolina, USA
– sequence: 4
  givenname: Philip T
  surname: Ninan
  fullname: Ninan, Philip T
  organization: Department of Psychiatry and Behavioral Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
– sequence: 5
  givenname: Richard
  surname: Bloch
  fullname: Bloch, Richard
  organization: Department of Psychiatry and Behavioral Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
– sequence: 6
  givenname: Sy A
  surname: Saeed
  fullname: Saeed, Sy A
  organization: Department of Psychiatry and Behavioral Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27835725$$D View this record in MEDLINE/PubMed
BookMark eNpN0DtPwzAQB3ALFdFSujEjjwyk-BHHCVspT6mICrJHjnNpg_LCdkDl05PSgrjh7obf3fA_RoO6qQGhU0qmPgnDy-V8PqXCEBqR4ACNGBXCkzIkg3_7EE2sfSN9CSKZJEdoyGTIhWRihL6uTbFaO7z46fEajGo3WFk861YV1E65oqlxk-PlWplK6cbtSd4YHBtQbqu24AZaA9b2_ArP8OvGOqj6a41f4KOAT6zqDD-BU96sVuXGFvYEHeaqtDDZzzGK727j-YO3eL5_nM8WnmacO0_4kWY6ECSSoS9FoEPQQSYhzYhOeaRTHaRM5DnTMqAZpJQqSmnIOE2jnAV8jM53b1vTvHdgXVIVVkNZqhqaziY05BGlEWd-Ty92VJvGWgN50pqiUmaTUJJs8076vJPfvHt-tv_cpRVkf_g3Xf4NSKZ9vQ
ContentType Journal Article
Copyright Copyright 2016 Physicians Postgraduate Press, Inc.
Copyright_xml – notice: Copyright 2016 Physicians Postgraduate Press, Inc.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.4088/PCC.15r01906
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2155-7780
ExternalDocumentID 10_4088_PCC_15r01906
27835725
Genre Meta-Analysis
Review
Systematic Review
Journal Article
GroupedDBID 1X7
53G
AAKDD
ACGFS
ADBBV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CGR
CUY
CVF
EBS
ECM
EIF
EJD
GX1
HYE
NPM
RNS
RPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c233t-549c2c6509784756c8ec6d7ebd0cb39cbc6b25ff2c761deb11a1118231b9f263
ISSN 2155-7780
IngestDate Thu Apr 11 22:55:48 EDT 2024
Fri Aug 23 01:00:14 EDT 2024
Thu May 23 23:36:09 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
License Copyright 2016 Physicians Postgraduate Press, Inc.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c233t-549c2c6509784756c8ec6d7ebd0cb39cbc6b25ff2c761deb11a1118231b9f263
Notes SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Review-1
ObjectType-Article-3
ObjectType-Undefined-4
PMID 27835725
PQID 1839119324
PQPubID 23479
ParticipantIDs proquest_miscellaneous_1839119324
crossref_primary_10_4088_PCC_15r01906
pubmed_primary_27835725
PublicationCentury 2000
PublicationDate 2016-Oct-20
PublicationDateYYYYMMDD 2016-10-20
PublicationDate_xml – month: 10
  year: 2016
  text: 2016-Oct-20
  day: 20
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Primary care companion for CNS disorders
PublicationTitleAlternate Prim Care Companion CNS Disord
PublicationYear 2016
SSID ssj0000507270
Score 2.3818407
SecondaryResourceType review_article
Snippet Bright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have...
BACKGROUNDBright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
SubjectTerms Antidepressive Agents - therapeutic use
Combined Modality Therapy - methods
Depressive Disorder - therapy
Humans
Phototherapy - methods
Randomized Controlled Trials as Topic
Title Bright Light Therapy as Augmentation of Pharmacotherapy for Treatment of Depression: A Systematic Review and Meta-Analysis
URI https://www.ncbi.nlm.nih.gov/pubmed/27835725
https://search.proquest.com/docview/1839119324
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLaGcuGCQGzDJiPBMSW2E6fmNgxLxWE0UoM0t8h2HKhEk2omufRX9Cf3eckyA5WAixUlzqL3Pr18z34LQm9ZJoRiuoyYJjxKZEYimVIZiVQYxmNpl55stMWKn35Pvm3SzWx2PYla6lp1rK_-mFfyP1qFc6BXmyX7D5odHgon4Bj0CyNoGMa_0vFH51qDX23H3NcHsI1jFt2Pi5BT5NjgOtSnbsMUG1qYDxHmMOFTHw9b-0z1s7G-c6i87-IxTCujvorJlNWuQ8kKH0bmLEwfwbhcndlNIFfhczfaYZdSMwYo7Xc11uedW79ttrX5Nd0r-tnAR3nCPSTmjLeuzkOvZb9IFMK_w4oGQAR-BdRvzhhn-YCGpED7fYun3810vxF-aP0TsJigsvVyeUzSrU2S59NpIMDLC4cE210kzXzC9UG17f7SHXTXlla03Ri-bsiwahcDfaZZ7DMo7PveT99mK0uH-_dpzi2-i-Mw-QN0PzgfeOGR9BDNTP0IXXkUYYciHFCE5Q5PUYSbCh-gCIN68YAiO2FE0Qe8wCOGsMcQBn3hPQw9RvmXz_nyNAodOSJNGWujNBGaalt0MQNWk3J9YjQvM6PKWCsmtNJc0bSqqM44KYEGEEmsB8uIEhXl7Ak6qpvaPEM4VlxksuKVEjIpMylSqkqqBS8Jk-Ykm6N3vfyKSw_iAvxVK_ICRF70Ip-jN71wCzCMdrdL1qbpdoWl_sS6J8kcPfVSH57Ua-n5rVdeoHsjNF-io3bbmVdAP1v12iHiBqZciNo
link.rule.ids 314,780,784,27924,27925
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bright+Light+Therapy+as+Augmentation+of+Pharmacotherapy+for+Treatment+of+Depression%3A+A+Systematic+Review+and+Meta-Analysis&rft.jtitle=Primary+care+companion+for+CNS+disorders&rft.au=Penders%2C+Thomas+M&rft.au=Stanciu%2C+Cornel+N&rft.au=Schoemann%2C+Alexander+M&rft.au=Ninan%2C+Philip+T&rft.date=2016-10-20&rft.eissn=2155-7780&rft.volume=18&rft.issue=5&rft_id=info:doi/10.4088%2FPCC.15r01906&rft_id=info%3Apmid%2F27835725&rft.externalDocID=27835725
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2155-7780&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2155-7780&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2155-7780&client=summon