p-Coumaric acid in poly(amidoamine) G4 dendrimer: Characterization and toxicity evaluation on zebrafish model

[Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is mai...

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Published inJournal of drug delivery science and technology Vol. 79; p. 104039
Main Authors Nasr, Gihane, Daakour, Sanaa, Banaszak Holl, Mark M., Attallah, Carla, Hamade, Aline, Greige-Gerges, Helene
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.01.2023
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Abstract [Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is maintained in the complex form.•The complex was able to abolish G4 PAMAM toxicity on zebrafish model.
AbstractList [Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is maintained in the complex form.•The complex was able to abolish G4 PAMAM toxicity on zebrafish model.
ArticleNumber 104039
Author Attallah, Carla
Hamade, Aline
Daakour, Sanaa
Nasr, Gihane
Banaszak Holl, Mark M.
Greige-Gerges, Helene
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Snippet [Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic...
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