p-Coumaric acid in poly(amidoamine) G4 dendrimer: Characterization and toxicity evaluation on zebrafish model
[Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is mai...
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Published in | Journal of drug delivery science and technology Vol. 79; p. 104039 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.01.2023
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Online Access | Get full text |
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Summary: | [Display omitted]
•Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is maintained in the complex form.•The complex was able to abolish G4 PAMAM toxicity on zebrafish model. |
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ISSN: | 1773-2247 |
DOI: | 10.1016/j.jddst.2022.104039 |