Effect of Succinate-Containing Infusion Solution
on Cellular Structures in Children in the Perioperative Period

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 11; no. 1; pp. 33 - 38
• Main Authors: Lazarev, V. V., Ermolaeva, K. R., Kochkin, V. S., Tsypin, L. E., Popova, T. G., Nikolaev, D. V., Bologov, A. A., Vaganov, N. N.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 26.02.2015
• Subjects: cellular structures; children; infusion therapy; phase angle; succinate-containing solution
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2015-1-33-38

Objective: to evaluate the effect of a 1.5% crystalloid polyionic Reamberin solution on cellular structures in children in the perioperative period. Subjects and methods. A randomized prospective study was conducted in 117 children aged 1 to 18 years during different surgical interventions under anesthesia with sevoflurane, fentanyl, or rocuronium to provide ASA I—II estimates. A study group included 55 children, in whom basic infusion therapy was switched to infusions of 1.5% Reamberin solution 20 minutes before the end of a surgical intervention. A comparison group comprised 62 children, in whom basic infusion therapy was switched to infusions of 0.9% NaCl solution 20 minutes before the end of surgery. In the study and control groups, the solutions were administered in a dose of 6—10 ml/kg depending on age at a rate of 2 ml/min. Results. 1.5% Reamberin solution was found to contribute to earlier and significant improvement in the function of cellular structures in children in the perioperative period.