Disappearance of cleft lip and/or palate by transplantation of fertilized ovum

The fertilized ovum of an animal model with spontaneous cleft lip and/or palate was transferred to an animal model that does not develop cleft lip or palate. Fifty-two fetuses were obtained by transferring the ovum of A/J strain mice to the uterus of C57BL/6 strain mice. Cleft lip and/or palate and...

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Bibliographic Details
Published inJapanese Journal of Oral and Maxillofacial Surgery Vol. 41; no. 2; pp. 97 - 103
Main Author TSUNODA, Noritaka
Format Journal Article
LanguageEnglish
Published Japanese Society of Oral and Maxillofacial Surgeons 1995
Subjects
blastocyst
cleft lip
cleft palate
mice
transfer
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.41.97

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Summary:The fertilized ovum of an animal model with spontaneous cleft lip and/or palate was transferred to an animal model that does not develop cleft lip or palate. Fifty-two fetuses were obtained by transferring the ovum of A/J strain mice to the uterus of C57BL/6 strain mice. Cleft lip and/or palate and other external malformations were not found in the fetuses by examination with a stereoscopic microscope. The results suggest the need to reconsider ovum transplantation for the prevention of cleft lip and/or palate.
ISSN:0021-5163
2186-1579
DOI:10.5794/jjoms.41.97