Technetium labeling of bi, tri and tetradentate ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid: Characterization and biodistribution of their oxo and nitrido 99mtechnetium complexes

We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN 2−, SNO 2−, SNN 2−, SNNO 3− and SNNN 3−) and different substituents on the sulfur moieties -SR (with R = H, CH 3 or C 2H 5O(CH 3)CH). With five of these ligands...

Full description

Saved in:

Bibliographic Details
Published in	Nuclear medicine and biology Vol. 23; no. 3; pp. 353 - 357
Main Authors	Belhadj-Tahar, H., Coulais, Y., Cros, G., Darbieu, M.H., Tafani, J.A.M., Fabre, J., Esquerré, J.P., Guiraud, R.
Format	Journal Article
Language	English
Published	Amsterdam Elsevier Inc 01.04.1996 Elsevier
Subjects	2-Aminocyclopentene-1-dithiocarboxylic acid Aminothiol Animals Biodistribution Biological and medical sciences Complexes Contrast media. Radiopharmaceuticals Isotope Labeling - methods Ligands Magnetic Resonance Spectroscopy Male Medical sciences Molecular Structure Nitridotechnetium Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship Technetium - pharmacokinetics Technetium-99m Thiones - chemical synthesis Thiones - chemistry Thiones - pharmacokinetics Tissue Distribution X-Ray Diffraction Nitridotechnetium 2-Aminocyclopentene-1-dithiocarboxylic acid Aminothiol Complexes Biodistribution Technetium-99m Radiolabelling Dithiocarboxylic acid Ligand Radiochemistry Technetium Bioavailability Experimental study Pharmacokinetics Chemical synthesis Chromatography Comparative study
Online Access	Get full text

Cover

Loading…

Abstract	We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN 2−, SNO 2−, SNN 2−, SNNO 3− and SNNN 3−) and different substituents on the sulfur moieties -SR (with R = H, CH 3 or C 2H 5O(CH 3)CH). With five of these ligands technetium nitrido complexes have been obtained with high yields (over 95%) using rather harsh conditions (pH ≈ 1, temperature ≥ 80 °C), whereas for technetium oxo complexes similar high yields were only obtained with two ligands but with mild conditions (pH = 7–8, temperature ≈ 50 °C). Changing an OH group for an NH 2 has a drastic effect upon labeling yields. The possibility of complexing ligands as either oxo (TcO) 3+ or nitrido (TcN) 2+ derivatives increases the number of available labeled agents with different overall change and consequently with different biological behavior.
AbstractList	We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN 2−, SNO 2−, SNN 2−, SNNO 3− and SNNN 3−) and different substituents on the sulfur moieties -SR (with R = H, CH 3 or C 2H 5O(CH 3)CH). With five of these ligands technetium nitrido complexes have been obtained with high yields (over 95%) using rather harsh conditions (pH ≈ 1, temperature ≥ 80 °C), whereas for technetium oxo complexes similar high yields were only obtained with two ligands but with mild conditions (pH = 7–8, temperature ≈ 50 °C). Changing an OH group for an NH 2 has a drastic effect upon labeling yields. The possibility of complexing ligands as either oxo (TcO) 3+ or nitrido (TcN) 2+ derivatives increases the number of available labeled agents with different overall change and consequently with different biological behavior. We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN2-, SNO2-, SNN2-, SNNO3- and SNNN3-) and different substituents on the sulfur moieties-SR (with R = H, CH3 or C2H5O(CH3)CH). With five of these ligands technetium nitrido complexes have been obtained with high yields (over 95%) using rather harsh conditions (pH = 1, temperature > or = 80 degrees C), whereas for technetium oxo complexes similar high yields were only obtained with two ligands but with mild conditions (pH = 7-8, temperature approximately equal to 50 degrees C). Changing an OH group for an NH2 has a drastic effect upon labeling yields. The possibility of complexing ligands as either oxo (TcO)3+ or nitrido (TcN)2+ derivatives increases the number of available labeled agents with different overall change and consequently with different biological behavior. We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN2-, SNO2-, SNN2-, SNNO3- and SNNN3-) and different substituents on the sulfur moieties-SR (with R = H, CH3 or C2H5O(CH3)CH). With five of these ligands technetium nitrido complexes have been obtained with high yields (over 95%) using rather harsh conditions (pH = 1, temperature > or = 80 degrees C), whereas for technetium oxo complexes similar high yields were only obtained with two ligands but with mild conditions (pH = 7-8, temperature approximately equal to 50 degrees C). Changing an OH group for an NH2 has a drastic effect upon labeling yields. The possibility of complexing ligands as either oxo (TcO)3+ or nitrido (TcN)2+ derivatives increases the number of available labeled agents with different overall change and consequently with different biological behavior.
Author	Fabre, J. Belhadj-Tahar, H. Cros, G. Guiraud, R. Darbieu, M.H. Tafani, J.A.M. Coulais, Y. Esquerré, J.P.
Author_xml	– sequence: 1 givenname: H. surname: Belhadj-Tahar fullname: Belhadj-Tahar, H. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France – sequence: 2 givenname: Y. surname: Coulais fullname: Coulais, Y. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France – sequence: 3 givenname: G. surname: Cros fullname: Cros, G. organization: Laboratoire de Chimie de Coordination du CNRS, UP 8241 Lié Par Convention À l'Université Paul Sabatier et À l'Institut National Polytechnique, 205 Route de Narbonne, 31077 Toulouse Cedex, France – sequence: 4 givenname: M.H. surname: Darbieu fullname: Darbieu, M.H. organization: Laboratoire de Chimie de Coordination du CNRS, UP 8241 Lié Par Convention À l'Université Paul Sabatier et À l'Institut National Polytechnique, 205 Route de Narbonne, 31077 Toulouse Cedex, France – sequence: 5 givenname: J.A.M. surname: Tafani fullname: Tafani, J.A.M. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France – sequence: 6 givenname: J. surname: Fabre fullname: Fabre, J. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France – sequence: 7 givenname: J.P. surname: Esquerré fullname: Esquerré, J.P. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France – sequence: 8 givenname: R. surname: Guiraud fullname: Guiraud, R. organization: Laboratoire d'Imagerie Morphologique et Fonctionnelle, EA 826, Faculté de Médecine Toulouse-Purpan, 133 Route de Narbonne, 31062 Toulouse Cedex, France
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3105638$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/8782247$$D View this record in MEDLINE/PubMed
BookMark	eNp9kduKFDEQhoOsrLOrb6CQCxEFW5PuTh_2QpDBEyx4s16HdKV6p6Q7GZPMMuML-lpmDox3XhXU__1VRf1X7MJ5h4w9l-KdFLJ5L_qmLzqh5OtevRGlFKIQj9hCdm1Z9I2sL9jijDxhVzH-FNlWS3HJLru2K8u6XbA_dwgrh4k2M5_MgBO5e-5HPtBbngJx4yxPmIKx6JJJyCe6z73ILQZ6QMvH4GdeFmYm52EHk19nEB0WsrCUVuTBhMFvdxMBN0D2hi9XJhhI2f_bJPLusGMgbynmjcPm0MsnpBVS4H7rD4CjLFrP-35O_04GP68n3GJ8yh6PZor47FSv2Y_Pn-6WX4vb71--LT_eFlBWVVtUYyMBeyVVqQwOoMCYqgFsbN-Ulenyh4yqFcpaVG0vRgSphOykaC1AFqpr9uo4dx38rw3GpGeKgNNkHPpN1PmvXSfKPVgfQQg-xoCjXgeaTdhpKfQ-P70PR-_D0b3Sh_y0yLYXp_mbYUZ7Np0Cy_rLk24imGkMxgHFM1ZJoZqqy9iHI4b5Fw-EQUcgdICWAkLS1tP_7_gL7xu8vg
CitedBy_id	crossref_primary_10_1021_jm0010825 crossref_primary_10_1177_026119290002800201 crossref_primary_10_1021_cr980436l crossref_primary_10_1016_j_ejmech_2015_05_014 crossref_primary_10_1039_ic093519 crossref_primary_10_1007_s10967_018_5924_z crossref_primary_10_1016_j_nucmedbio_2010_04_139 crossref_primary_10_1007_s10967_014_3059_4 crossref_primary_10_1016_S0969_8051_97_00138_8 crossref_primary_10_1016_j_nima_2006_10_049
Cites_doi	10.1016/0883-2889(91)90190-C 10.1016/0969-8051(94)90018-3 10.1016/0020-1693(94)04127-X 10.1021/ic50187a005 10.1016/0883-2889(89)90102-0 10.1007/BF00618011 10.1021/jo01255a054 10.1016/0969-8051(94)90004-3 10.1021/jm00122a024 10.1016/S0006-3061(00)80108-8 10.1016/S0010-8545(00)80003-X 10.1007/BF00935932
ContentType	Journal Article
Copyright	1996 1996 INIST-CNRS
Copyright_xml	– notice: 1996 – notice: 1996 INIST-CNRS
DBID	IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
DOI	10.1016/0969-8051(95)02100-0
DatabaseName	Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Biology Physics
EISSN	1872-9614
EndPage	357
ExternalDocumentID	10_1016_0969_8051_95_02100_0 8782247 3105638 0969805195021000
Genre	Journal Article
GroupedDBID	--- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29N 4.4 457 4CK 4G. 53G 5RE 5VS 7-5 71M 8P~ 8WZ 9JM A6W AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABBQC ABFNM ABGSF ABJNI ABLJU ABLVK ABMAC ABMZM ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACIWK ACPRK ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AEVXI AFKWA AFRAH AFRHN AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEI HMK HMO HVGLF HZ~ IHE J1W KOM LCYCR M29 M41 MO0 N9A O-L O9- OAUVE OGGZJ OI~ OU0 OZT P-8 P-9 P2P PC. Q38 R2- RIG RNS ROL RPZ SAE SDF SDG SEL SES SEW SPCBC SSH SSP SSU SSZ T5K UHS WH7 WUQ Z5R ZA5 ~G- AAPBV ABPIF ABPTK IQODW AAXKI AFCTW AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
ID	FETCH-LOGICAL-c2337-3f61ce951525aebc5caa36ce6d9623a8001a545e1403790fec15018107dcc5453
IEDL.DBID	AIKHN
ISSN	0969-8051
IngestDate	Fri Aug 16 23:47:48 EDT 2024 Thu Sep 26 18:54:54 EDT 2024 Sat Sep 28 07:34:15 EDT 2024 Sun Oct 29 17:09:16 EDT 2023 Fri Feb 23 02:33:20 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	Nitridotechnetium 2-Aminocyclopentene-1-dithiocarboxylic acid Aminothiol Complexes Biodistribution Technetium-99m Radiolabelling Dithiocarboxylic acid Ligand Radiochemistry Technetium Bioavailability Experimental study Pharmacokinetics Chemical synthesis Chromatography Comparative study
Language	English
License	CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c2337-3f61ce951525aebc5caa36ce6d9623a8001a545e1403790fec15018107dcc5453
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	8782247
PQID	78288025
PQPubID	23479
PageCount	5
ParticipantIDs	proquest_miscellaneous_78288025 crossref_primary_10_1016_0969_8051_95_02100_0 pubmed_primary_8782247 pascalfrancis_primary_3105638 elsevier_sciencedirect_doi_10_1016_0969_8051_95_02100_0
PublicationCentury	1900
PublicationDate	1996-Apr
PublicationDateYYYYMMDD	1996-04-01
PublicationDate_xml	– month: 04 year: 1996 text: 1996-Apr
PublicationDecade	1990
PublicationPlace	Amsterdam
PublicationPlace_xml	– name: Amsterdam – name: United States
PublicationTitle	Nuclear medicine and biology
PublicationTitleAlternate	Nucl Med Biol
PublicationYear	1996
Publisher	Elsevier Inc Elsevier
Publisher_xml	– name: Elsevier Inc – name: Elsevier
References	Coulais, Cros, Darbieu, Tafani, Belhadj-Tahar, Bellande, Pasqualini, Guiraud (BIB6) 1994; 21 Lever, Kwamena, Baidoo, Mahmood, Matsumura, Schefefel, Wagner (BIB13) 1994; 21 Oldendorf (BIB15) 1978; 19 Chen, Cummings (BIB3) 1978; 17 Griffith (BIB10) 1972; 8 Kung, Guo, Yu, Billings, Subramanyam, Calabrese (BIB12) 1989; 32 Liu, Edwards (BIB14) 1994 Shiba, Mori, Matsuda, Tsuji, Kinuya, Hisada (BIB18) 1991; 42 Cros, Belhadj-Tahar, de Montauzon, Gleizes, Coulais, Guiraud, Bellande, Pasqualini (BIB8) 1994; 227 Roy, Parimal, Nag (BIB17) 1984; 9 Chiotellis, Varvarigou, Maina, Stassinopoulou (BIB4) 1988; 15 Cros, Coulais, Belhadj-Tahar, Gleizes, Guiraud (BIB7) 1994 Costes, Cros, Darbieu, Laurent (BIB5) 1982; 7 Walowitch, Makuch, Watson, Williams (BIB20) 1988; 29 Kasina, Rao, Srinivasan, Sanderson, Fitzner, Reno, Beaumier, Fritzberg (BIB11) 1991; 32 Belhadj-Tahar, Cros, Darbieu, Tafani, Coulais, Guiraud (BIB2) 1994; 18 Davison (BIB9) 1983 Takeshima, Yokoyama, Imamoto, Asaba (BIB19) 1969; 34 Alagui, Apparu, Du Moulinet d'Hardemare, Riche, Vidai (BIB1) 1989; 40 Patterson, Holm (BIB16) 1975; 4 Liu (10.1016/0969-8051(95)02100-0_BIB14) 1994 Costes (10.1016/0969-8051(95)02100-0_BIB5) 1982; 7 Kasina (10.1016/0969-8051(95)02100-0_BIB11) 1991; 32 Walowitch (10.1016/0969-8051(95)02100-0_BIB20) 1988; 29 Alagui (10.1016/0969-8051(95)02100-0_BIB1) 1989; 40 Coulais (10.1016/0969-8051(95)02100-0_BIB6) 1994; 21 Cros (10.1016/0969-8051(95)02100-0_BIB8) 1994; 227 Takeshima (10.1016/0969-8051(95)02100-0_BIB19) 1969; 34 Belhadj-Tahar (10.1016/0969-8051(95)02100-0_BIB2) 1994; 18 Chen (10.1016/0969-8051(95)02100-0_BIB3) 1978; 17 Chiotellis (10.1016/0969-8051(95)02100-0_BIB4) 1988; 15 Roy (10.1016/0969-8051(95)02100-0_BIB17) 1984; 9 Oldendorf (10.1016/0969-8051(95)02100-0_BIB15) 1978; 19 Cros (10.1016/0969-8051(95)02100-0_BIB7) 1994 Davison (10.1016/0969-8051(95)02100-0_BIB9) 1983 Patterson (10.1016/0969-8051(95)02100-0_BIB16) 1975; 4 Shiba (10.1016/0969-8051(95)02100-0_BIB18) 1991; 42 Kung (10.1016/0969-8051(95)02100-0_BIB12) 1989; 32 Griffith (10.1016/0969-8051(95)02100-0_BIB10) 1972; 8 Lever (10.1016/0969-8051(95)02100-0_BIB13) 1994; 21
References_xml	– volume: 21 start-page: 157 year: 1994 end-page: 164 ident: BIB13 article-title: Novel technétium ligands with affinity for muscarinic cholinergic receptor publication-title: Nucl. Med. Biol. contributor: fullname: Wagner – volume: 32 start-page: 433 year: 1989 end-page: 437 ident: BIB12 article-title: New brain perfusion imaging agents based on publication-title: J. Med. Chem. contributor: fullname: Calabrese – volume: 29 start-page: 747 year: 1988 ident: BIB20 article-title: Brain retention of publication-title: J. Nucl. Med. contributor: fullname: Williams – volume: 42 start-page: 1159 year: 1991 end-page: 1164 ident: BIB18 article-title: Synthesis of technetium-99m labeled diaminodithiol for bifunctional chelating agents publication-title: Appl. Radiat. Isot. contributor: fullname: Hisada – volume: 40 start-page: 813 year: 1989 end-page: 817 ident: BIB1 article-title: Etude de la stabilité de la liaison publication-title: Int. J. Radiat. Appl. Instrum. contributor: fullname: Vidai – volume: 17 start-page: 2358 year: 1978 end-page: 2361 ident: BIB3 article-title: Synthesis and characterisation of Cobalt(II) and some Nickel(II) complexes with publication-title: Inorg. Chem. contributor: fullname: Cummings – volume: 9 start-page: 152 year: 1984 end-page: 155 ident: BIB17 article-title: Metal complexes of sulfur-nitrogen chelating agents: Part 12—The chemistry of nickel(II), palladium(II), cobalt(II) and copper(II) complexes of N publication-title: Transition Met. Chem. contributor: fullname: Nag – volume: 15 start-page: 215 year: 1988 end-page: 223 ident: BIB4 article-title: Comparative evaluation of publication-title: Nucl. Med. Biol. contributor: fullname: Stassinopoulou – volume: 4 start-page: 257 year: 1975 end-page: 275 ident: BIB16 article-title: Structural and electronic effects on the polarographic half-wave potentials of copper(II) chelate complexes publication-title: Bioinorg. Chem. contributor: fullname: Holm – volume: 7 start-page: 219 year: 1982 end-page: 223 ident: BIB5 article-title: Electrochemical study of some cobalt Schiff base complexes and their methyl derivatives: Relation to the behaviour of the cobalt-carbon bond publication-title: Transition Met. Chem. contributor: fullname: Laurent – start-page: 383 year: 1994 end-page: 393 ident: BIB14 article-title: New N publication-title: Technetium and Rhenium in Chemistry and Nuclear Medicine contributor: fullname: Edwards – start-page: 85 year: 1994 end-page: 87 ident: BIB7 article-title: Synthesis and characterization of oxo and nitrido complexes of technetium-99(V) and rhenium(V) with new SNO and SN publication-title: Technetium and Rhenium in Chemistry and Nuclear Medicine contributor: fullname: Guiraud – volume: 8 start-page: 369 year: 1972 end-page: 396 ident: BIB10 article-title: Transition metal nitrido complexes publication-title: Coord. Chem. Rev. contributor: fullname: Griffith – start-page: 3 year: 1983 end-page: 14 ident: BIB9 article-title: The coordination chemistry of technetium publication-title: Technetium and Rhenium in Chemistry and Nuclear Medicine contributor: fullname: Davison – volume: 32 start-page: 1445 year: 1991 end-page: 1451 ident: BIB11 article-title: Development and biologic evaluation of kit for performed chelate technetium-99 m. radiolabeling of an antibody Fab fragment using a diamide dimercaptide chelating agent publication-title: J. Nucl. Med. contributor: fullname: Fritzberg – volume: 19 start-page: 1182 year: 1978 ident: BIB15 article-title: Need for new radiopharmaceuticals publication-title: J. Nucl. Med. contributor: fullname: Oldendorf – volume: 18 start-page: 243 year: 1994 ident: BIB2 article-title: Etude des potentialités de complexation de nouvelles bases de Schiff non-symétriques dérivées de l'acide dithiocarboxylique avec le technétium publication-title: Med. Nucl. contributor: fullname: Guiraud – volume: 227 start-page: 25 year: 1994 end-page: 31 ident: BIB8 article-title: Synthesis and characterization of neutral oxorhenium(V) and nitrido-technetium(V) complexes with a tetradendate N publication-title: Inorg. Chim. Acta. contributor: fullname: Pasqualini – volume: 21 start-page: 263 year: 1994 end-page: 268 ident: BIB6 article-title: Synthesis, characterization and biodistribution of new publication-title: Nucl. Med. Biol. contributor: fullname: Guiraud – volume: 34 start-page: 730 year: 1969 end-page: 732 ident: BIB19 article-title: The reaction of active methylene compounds with carbon disulfide in the presence of ammonia. III. The reactions of cyclopentanone and cycloheptanone publication-title: J. Org. Chem. contributor: fullname: Asaba – volume: 42 start-page: 1159 year: 1991 ident: 10.1016/0969-8051(95)02100-0_BIB18 article-title: Synthesis of technetium-99m labeled diaminodithiol for bifunctional chelating agents publication-title: Appl. Radiat. Isot. doi: 10.1016/0883-2889(91)90190-C contributor: fullname: Shiba – volume: 21 start-page: 263 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB6 article-title: Synthesis, characterization and biodistribution of new 99mTc oxo and nitrido complexes with bi- and tetradentate unsaturated NS and N2S2 Schiff bases derived from 2-aminocyclopentene-1-dithio-carboxylic acid as potential heart imagining agents publication-title: Nucl. Med. Biol. doi: 10.1016/0969-8051(94)90018-3 contributor: fullname: Coulais – volume: 227 start-page: 25 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB8 article-title: Synthesis and characterization of neutral oxorhenium(V) and nitrido-technetium(V) complexes with a tetradendate N2S2 unsaturated ligand derived from dithiocarboxylic acid publication-title: Inorg. Chim. Acta. doi: 10.1016/0020-1693(94)04127-X contributor: fullname: Cros – start-page: 383 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB14 article-title: New N2S2 diamidedithiols and N3S triamidithiols as bifunctional chelating agents for labeling small peptides with 99mTc contributor: fullname: Liu – volume: 17 start-page: 2358 year: 1978 ident: 10.1016/0969-8051(95)02100-0_BIB3 article-title: Synthesis and characterisation of Cobalt(II) and some Nickel(II) complexes with N,N′-ethylene bis(p-X-benzoylacetone iminato) and N,N′ ethylene bis(p-benzoylmonothioacetone iminato) ligands publication-title: Inorg. Chem. doi: 10.1021/ic50187a005 contributor: fullname: Chen – start-page: 3 year: 1983 ident: 10.1016/0969-8051(95)02100-0_BIB9 article-title: The coordination chemistry of technetium contributor: fullname: Davison – volume: 40 start-page: 813 year: 1989 ident: 10.1016/0969-8051(95)02100-0_BIB1 article-title: Etude de la stabilité de la liaison 99mTc ≅ N en fonction du pH: Mise en évidence de la transformation de [99mTcNCl4]− en 99mTcO4− publication-title: Int. J. Radiat. Appl. Instrum. doi: 10.1016/0883-2889(89)90102-0 contributor: fullname: Alagui – volume: 29 start-page: 747 year: 1988 ident: 10.1016/0969-8051(95)02100-0_BIB20 article-title: Brain retention of 99mTc-ECD is related to in vivo metabolism publication-title: J. Nucl. Med. contributor: fullname: Walowitch – volume: 7 start-page: 219 year: 1982 ident: 10.1016/0969-8051(95)02100-0_BIB5 article-title: Electrochemical study of some cobalt Schiff base complexes and their methyl derivatives: Relation to the behaviour of the cobalt-carbon bond publication-title: Transition Met. Chem. doi: 10.1007/BF00618011 contributor: fullname: Costes – volume: 34 start-page: 730 year: 1969 ident: 10.1016/0969-8051(95)02100-0_BIB19 article-title: The reaction of active methylene compounds with carbon disulfide in the presence of ammonia. III. The reactions of cyclopentanone and cycloheptanone publication-title: J. Org. Chem. doi: 10.1021/jo01255a054 contributor: fullname: Takeshima – volume: 18 start-page: 243 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB2 article-title: Etude des potentialités de complexation de nouvelles bases de Schiff non-symétriques dérivées de l'acide dithiocarboxylique avec le technétium publication-title: Med. Nucl. contributor: fullname: Belhadj-Tahar – volume: 21 start-page: 157 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB13 article-title: Novel technétium ligands with affinity for muscarinic cholinergic receptor publication-title: Nucl. Med. Biol. doi: 10.1016/0969-8051(94)90004-3 contributor: fullname: Lever – volume: 32 start-page: 1445 year: 1991 ident: 10.1016/0969-8051(95)02100-0_BIB11 article-title: Development and biologic evaluation of kit for performed chelate technetium-99 m. radiolabeling of an antibody Fab fragment using a diamide dimercaptide chelating agent publication-title: J. Nucl. Med. contributor: fullname: Kasina – volume: 32 start-page: 433 year: 1989 ident: 10.1016/0969-8051(95)02100-0_BIB12 article-title: New brain perfusion imaging agents based on 99mTc-bis (amino-ethanethiol) complexes: Stereoisomers and biodistribution publication-title: J. Med. Chem. doi: 10.1021/jm00122a024 contributor: fullname: Kung – volume: 19 start-page: 1182 year: 1978 ident: 10.1016/0969-8051(95)02100-0_BIB15 article-title: Need for new radiopharmaceuticals publication-title: J. Nucl. Med. contributor: fullname: Oldendorf – volume: 4 start-page: 257 year: 1975 ident: 10.1016/0969-8051(95)02100-0_BIB16 article-title: Structural and electronic effects on the polarographic half-wave potentials of copper(II) chelate complexes publication-title: Bioinorg. Chem. doi: 10.1016/S0006-3061(00)80108-8 contributor: fullname: Patterson – volume: 15 start-page: 215 year: 1988 ident: 10.1016/0969-8051(95)02100-0_BIB4 article-title: Comparative evaluation of 99mTc-labeled aminothiols as possible brain imaging agents publication-title: Nucl. Med. Biol. contributor: fullname: Chiotellis – start-page: 85 year: 1994 ident: 10.1016/0969-8051(95)02100-0_BIB7 article-title: Synthesis and characterization of oxo and nitrido complexes of technetium-99(V) and rhenium(V) with new SNO and SN2O ligands: Biodistribution study of the related 99mTc-complexes contributor: fullname: Cros – volume: 8 start-page: 369 year: 1972 ident: 10.1016/0969-8051(95)02100-0_BIB10 article-title: Transition metal nitrido complexes publication-title: Coord. Chem. Rev. doi: 10.1016/S0010-8545(00)80003-X contributor: fullname: Griffith – volume: 9 start-page: 152 year: 1984 ident: 10.1016/0969-8051(95)02100-0_BIB17 article-title: Metal complexes of sulfur-nitrogen chelating agents: Part 12—The chemistry of nickel(II), palladium(II), cobalt(II) and copper(II) complexes of N2S2 and N3S2 donor systems publication-title: Transition Met. Chem. doi: 10.1007/BF00935932 contributor: fullname: Roy
SSID	ssj0016410
Score	1.4898356
Snippet	We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN 2−, SNO 2−, SNN 2−,... We have synthesized and characterized seven ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid with different donor sets (SN2-, SNO2-, SNN2-,...
SourceID	proquest crossref pubmed pascalfrancis elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	353
SubjectTerms	2-Aminocyclopentene-1-dithiocarboxylic acid Aminothiol Animals Biodistribution Biological and medical sciences Complexes Contrast media. Radiopharmaceuticals Isotope Labeling - methods Ligands Magnetic Resonance Spectroscopy Male Medical sciences Molecular Structure Nitridotechnetium Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship Technetium - pharmacokinetics Technetium-99m Thiones - chemical synthesis Thiones - chemistry Thiones - pharmacokinetics Tissue Distribution X-Ray Diffraction
Title	Technetium labeling of bi, tri and tetradentate ligands derived from 2-aminocyclopentene-1-dithiocarboxylic acid: Characterization and biodistribution of their oxo and nitrido 99mtechnetium complexes
URI	https://dx.doi.org/10.1016/0969-8051(95)02100-0 https://www.ncbi.nlm.nih.gov/pubmed/8782247 https://search.proquest.com/docview/78288025
Volume	23
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZgKxASqqBQsUCLDxxAwmxix3lwqyqqBdSeqNSb5VeQpd1klc2i3Qt_j7_F2Hm0PVSVuDp2YnnGM5_j-WYQek_zXGWypCRiipMEuhHoqUjMypyaPFK09Gzk84t0fpl8v-JXN7gwPqyyt_2dTQ_Wum-Z9as5Wzk3A-xd5B6AcH9sieDYvgfeKEkmaO_k24_5xXiXkCYhJ4HvT_yAgUAXp7Ox7UPBP4bXkOguB_V0JdewbGVX7-JuQBoc09kztN8jSnzSTfo5emCrA_SoqzG5O0CPz_vbc2gM4Z56_QL9DX_Ubes2SwxqEDjpuC6xcp9w2zgsK4Nb2zbSBGqSxQv3y3OCsQGF_W0N9qwUTIlcuqrWO73wRbgAfVs4KnqWhwMP2ah6u1s4jaV25gs-HTNDd8TP8A3lauMz9_ZFt_wUws0Frrd16AAGp3GmxkWxbK-nHOLg7dauX6LLs68_T-ekL-lANGUMzFmZxtoCquOUS6s011KyVNvUFIDDJKDXWAKmsz6LYFZEpdVxyDgYZUZreMAO0aSqK_sK4bykGbUGDkgFS1jGpaZUxpblipnIRmaKyCBHseoyd4ghpM3LXXi5i4KLIHcRTVE2CFvc0kABzuWekUe3dGP8HEBnDvZtit4NuiJg8_obGVnZerMWAM_AflI-RYedCo1Dc4_ckuz1f0_qDXrSBZj7IKO3aNI2G3sE-KlVx-jh5z_xcb9N_gFllxhy
link.rule.ids	315,786,790,4521,24144,27955,27956,45618,45712
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZQEQ8JIShULFDqAweQCJvY6zy4oYpqgW5PrdSb5VcqS7vJajdb7V769_hbzDgP6KFC4upMEsszGX8TzzdDyHuW5zpTJYtirkU0AbEIJHWU8DJnNo81K5GNPDtLpxeTH5fi8i8uDKZVdr6_9enBW3cj4241x0vvx4C9ixwBiMCwJYaw_T6CAUzr-nwzpHlANBAqEqB0hOI9fS5Jx8PYh0J8DA-J4ru2pydLtYZFK9tuF3fD0bAtnTwjTzs8Sb-2U35O7rlqnzxoO0zu9snDWXd2DoMh2dOsX5Bf4X-6a_xmQcEIAiOd1iXV_hNtVp6qytLGNStlAzHJ0bm_QkYwtWCu185S5KRQFqmFr2qzM3NswQXY20GgiBwPD_vjStfb3dwbqoy3X-jxUBe6pX2Gd2hfW6zb27XcwimEcwtab-sgAO5m5W1Ni2LR_JlyyIJ3W7d-SS5Ovp0fT6OuoUNkGOfgzMo0MQ4wnWBCOW2EUYqnxqW2ABSmALsmChCdwxqCWRGXziSh3mCcWWPgAj8ge1VduVeE5iXLmLMQHhV8wjOhDGMqcTzX3MYutiMS9XqUy7Zuh-wT2lDvEvUuCyGD3mU8IlmvbHnL_iRsLf-48_CWbQyvA-AswLuNyFFvKxI-XTyPUZWrN2sJ4Ay8JxMjctCa0HBrjrhtkr3-70kdkUfT89mpPP1-9vMNedymmmO60Vuy16w27hCQVKPfhU_lN-T4GUc
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Technetium+labeling+of+bi%2C+tri+and+tetradentate+ligands+derived+from+2-aminocyclopentene-1-dithiocarboxylic+acid%3A+Characterization+and+biodistribution+of+their+oxo+and+nitrido+99mtechnetium+complexes&rft.jtitle=Nuclear+medicine+and+biology&rft.au=Belhadj-Tahar%2C+H.&rft.au=Coulais%2C+Y.&rft.au=Cros%2C+G.&rft.au=Darbieu%2C+M.H.&rft.date=1996-04-01&rft.pub=Elsevier+Inc&rft.issn=0969-8051&rft.eissn=1872-9614&rft.volume=23&rft.issue=3&rft.spage=353&rft.epage=357&rft_id=info:doi/10.1016%2F0969-8051%2895%2902100-0&rft.externalDocID=0969805195021000
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0969-8051&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0969-8051&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0969-8051&client=summon