Aripiprazole Prolongs Morphine Antinociception Effect and Disrupts Acute Morphine Tolerance

• Published in: Biomedical & pharmacology journal Vol. 10; no. 3; pp. 1149 - 1157
• Main Authors: Norouzi, Marzieh, Mousavi, Zahra, Shafaroodi, Hamed
• Format: Journal Article
• Language: English
• Published: Bhopal Biomedical and Pharmacology Journal 2017
• Subjects: Analgesics; Antipsychotics; Aripiprazole; Dopamine; Dopamine D2 receptors; Drug dosages; Drug tolerance; Experiments; Morphine; Narcotics; Opioids; Pain; Pain perception; Psychotropic drugs; Restless legs syndrome; Rodents; Serotonin; Statistical analysis; Iran

Aripiprazole is an atypical antipsychotic drug mainly characterized by partial agonist activity at dopamine D2 and serotonin-1A receptors with minimal side effects. Based on typical antipsychotic pharmacological activity, including antinociception effect and disruption opioid anti-nociceptive tolera...