A Case Report: Dizziness due to Vasovagal Reflex Diagnosed by an Exercise Test

Dizziness based on sympathetic nervous disturbances is primarily due to either vasovagal reflex (VVR) or an orthostatic degegulation. The head up tilt test is useful for a differential diagnosis of them but it is not useful for a clinical diagnosis. We report a case where an exercise test was used t...

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Published inEquilibrium Research Vol. 59; no. 4; pp. 283 - 289
Main Authors Nakagawa, Masafumi, Yokoi, Hidenori, Okugawa, Mariko, Higashiyama, Emi, Masaki, Yoshio, Ando, Ichiro, Ichikawa, Ginichiro
Format Journal Article
LanguageEnglish
Published Japan Society for Equilibrium Research 2000
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ISSN0385-5716
1882-577X
DOI10.3757/jser.59.283

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Abstract Dizziness based on sympathetic nervous disturbances is primarily due to either vasovagal reflex (VVR) or an orthostatic degegulation. The head up tilt test is useful for a differential diagnosis of them but it is not useful for a clinical diagnosis. We report a case where an exercise test was used to clinically confirm dizziness due to VVR. A 13-year-old male visited our hospital complaining of recurring dizziness during exercise. He was examined by the pediatric department and underwent holter ECG, master ECG, brain MRI and head up tilt tests, but they were inconclusive. He was then examined in our department and we suspected VVR due to presenting symptoms and the negative clinical findings. Thus, an exercise test was performed to confirm our diagnosis. The subject steps up and down on a stair until they complain of sensations such as dizziness and nausea. Vital signs and the plasma adrenaline level are checked every 5 minutes during exercise and pre and post exercise. At 25 minutes he complained of dizziness, bradycardia, low blood pressure and a high plasma adrenaline level. The attack recurred with severe bradycardia (28/min) and a high plasma adrenaline level at 10 minutes after the test. We diagnosed it as a VVR attack. VVR is caused by excessive left ventricular contractions to adjust for blood volume retention in the legs while standing and/or sitting. The mechano-receptor also makes a paradoxical emission to the vagal nerve resulting in bradycardia, dizziness, and syncope. We recommend checking the plasma adrenaline level during VVR.
AbstractList Dizziness based on sympathetic nervous disturbances is primarily due to either vasovagal reflex (VVR) or an orthostatic degegulation. The head up tilt test is useful for a differential diagnosis of them but it is not useful for a clinical diagnosis. We report a case where an exercise test was used to clinically confirm dizziness due to VVR. A 13-year-old male visited our hospital complaining of recurring dizziness during exercise. He was examined by the pediatric department and underwent holter ECG, master ECG, brain MRI and head up tilt tests, but they were inconclusive. He was then examined in our department and we suspected VVR due to presenting symptoms and the negative clinical findings. Thus, an exercise test was performed to confirm our diagnosis. The subject steps up and down on a stair until they complain of sensations such as dizziness and nausea. Vital signs and the plasma adrenaline level are checked every 5 minutes during exercise and pre and post exercise. At 25 minutes he complained of dizziness, bradycardia, low blood pressure and a high plasma adrenaline level. The attack recurred with severe bradycardia (28/min) and a high plasma adrenaline level at 10 minutes after the test. We diagnosed it as a VVR attack. VVR is caused by excessive left ventricular contractions to adjust for blood volume retention in the legs while standing and/or sitting. The mechano-receptor also makes a paradoxical emission to the vagal nerve resulting in bradycardia, dizziness, and syncope. We recommend checking the plasma adrenaline level during VVR.
Author Masaki, Yoshio
Higashiyama, Emi
Ando, Ichiro
Okugawa, Mariko
Ichikawa, Ginichiro
Yokoi, Hidenori
Nakagawa, Masafumi
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14) 中川陽之,小林洋一,神保芳宏,他:Vasovagal syncopeにおける血中arginine-vasopressin,norepinephrine動態.心臓ペーシング10:288,1994
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6) 別役徹生,高野英行:神経調節性失神患者のヘッドアップチルト試験中の血中カテコールアミン濃度の検討.心臓26:54-57,1994
12) 正木義男,渡辺道隆,古川朋靖,他:血管迷走神経反射にけるアドレナリンの脳血流に及ぼす影響―ネコを使用した血管迷走神経反射の実験的モデル―.Equilibrium Res 57:529-535,1998
11) Janosik DL, Genovely.H, Fredman C, et al: Discrepancy between head-up tilt test results utilizing different protocols in the same patient. Am Heart J 123:538-541, 1992
13) Levy M N, Zieske H: Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J appl physiol 27: 465-470, 1969
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5) Thomas K, Dietrich K, YI-GANG LI, et al: Changes in plasma epinephrine concentration and in heart rate during head up tilt testing in patients with neurocardiogenic syncope. J Cardiovasc Electrophysiol 7: 802-808, 1996
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3) 水牧功一:失神―立位負荷試験の意義.Current Topics in Cardiology 13:22-32,1995
References_xml – reference: 6) 別役徹生,高野英行:神経調節性失神患者のヘッドアップチルト試験中の血中カテコールアミン濃度の検討.心臓26:54-57,1994
– reference: 10) 千代田和美,小林洋一,神保芳宏,他:Vasovagal syncope患者における急死例.心臓ペーシング10:288,1994
– reference: 2) 佐藤廣,飯沼宏之:失神とTilting Test.内科74:129-133. 1994
– reference: 8) 栗田明,高瀬凡平:Head-Up Tilt試験.呼吸と循環43:357-362,1995
– reference: 3) 水牧功一:失神―立位負荷試験の意義.Current Topics in Cardiology 13:22-32,1995
– reference: 9) 正木義男,渡辺道隆,古川朋靖,他:血管迷走神経反射が原因と考えられためまいの三症例.Equilibrium Res 57:297-304,1998
– reference: 4) 安部治彦:神経調節性失神(Neurally MediatedSyncope)の治療はどこまで行うべきか.不整脈News & Views 10:9-14,1995
– reference: 5) Thomas K, Dietrich K, YI-GANG LI, et al: Changes in plasma epinephrine concentration and in heart rate during head up tilt testing in patients with neurocardiogenic syncope. J Cardiovasc Electrophysiol 7: 802-808, 1996
– reference: 13) Levy M N, Zieske H: Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J appl physiol 27: 465-470, 1969
– reference: 11) Janosik DL, Genovely.H, Fredman C, et al: Discrepancy between head-up tilt test results utilizing different protocols in the same patient. Am Heart J 123:538-541, 1992
– reference: 14) 中川陽之,小林洋一,神保芳宏,他:Vasovagal syncopeにおける血中arginine-vasopressin,norepinephrine動態.心臓ペーシング10:288,1994
– reference: 12) 正木義男,渡辺道隆,古川朋靖,他:血管迷走神経反射にけるアドレナリンの脳血流に及ぼす影響―ネコを使用した血管迷走神経反射の実験的モデル―.Equilibrium Res 57:529-535,1998
– reference: 1) Lewis T: Vasovagal syncope and the carotid sinus mechanisms. Br Med J 1: 873-876, 1932
– reference: 7) 住吉正孝:不整脈の新しい診断法と非薬物療法.順天堂医42:450-458,1997
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Snippet Dizziness based on sympathetic nervous disturbances is primarily due to either vasovagal reflex (VVR) or an orthostatic degegulation. The head up tilt test is...
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StartPage 283
SubjectTerms autonomic nervous system
dizziness
exercise test
head up tilt test
vasovagal reflex
Title A Case Report: Dizziness due to Vasovagal Reflex Diagnosed by an Exercise Test
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